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The map label for this gene is holC [H]

Identifier: 54295471

GI number: 54295471

Start: 2920881

End: 2921315

Strand: Direct

Name: holC [H]

Synonym: lpl2557

Alternate gene names: 54295471

Gene position: 2920881-2921315 (Clockwise)

Preceding gene: 54295470

Following gene: 54295475

Centisome position: 87.3

GC content: 37.7

Gene sequence:

>435_bases
ATGTCGCCAATTCGCGTTGATTTTTACTTATTAGCCAGCAGCCTTCCAGAATCTCGCTGGTTGGTTGCTTGTCGTTTAAT
AGAAAAAGCCTATACCAAAGGACATACTATTTTTGTTTTTTGCGACAATCAGCAACAAGCAGAATACCTTGATGAATTAT
TGTGGACTTTCAAAGACGACAGTTTTATTCCTCATAATTTGCAAGGTGAAGGACCGGAGCCTCCTCCTCCCGTACAAATT
GGCTATCAAAAAGAACCCAGAGGCTTTACAGATATCCTGTTGAATTTATCCACCAATATTCCAATTTTTTATACCCGATT
TAAAAGAGTCATTGAATTGGTGAGTAATGTAGAACATGAGAAAGAAGTGAGTCGATTGCACTATAAAAAATATAGAAACA
AAGGCTGTGCATTGCACACACACTCGATTGAATAA

Upstream 100 bases:

>100_bases
CGTTGGGCCCATTTGGACATCGCAGGAACAGCCTGGATTTCTGGAAAGAAGCGTAATGCAACAGGGCGTCCTGTTCCTTT
ATTAATTCAATTATTGCGCC

Downstream 100 bases:

>100_bases
ATATTTTTCTTCTCGCTGGATTTTTAAGCTTATTGTATATCCGCTCCCTGATGGTCGCGGCTCTGATTATAATAAAGTAA
AACAGAGCCGCGACCATCAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MSPIRVDFYLLASSLPESRWLVACRLIEKAYTKGHTIFVFCDNQQQAEYLDELLWTFKDDSFIPHNLQGEGPEPPPPVQI
GYQKEPRGFTDILLNLSTNIPIFYTRFKRVIELVSNVEHEKEVSRLHYKKYRNKGCALHTHSIE

Sequences:

>Translated_144_residues
MSPIRVDFYLLASSLPESRWLVACRLIEKAYTKGHTIFVFCDNQQQAEYLDELLWTFKDDSFIPHNLQGEGPEPPPPVQI
GYQKEPRGFTDILLNLSTNIPIFYTRFKRVIELVSNVEHEKEVSRLHYKKYRNKGCALHTHSIE
>Mature_143_residues
SPIRVDFYLLASSLPESRWLVACRLIEKAYTKGHTIFVFCDNQQQAEYLDELLWTFKDDSFIPHNLQGEGPEPPPPVQIG
YQKEPRGFTDILLNLSTNIPIFYTRFKRVIELVSNVEHEKEVSRLHYKKYRNKGCALHTHSIE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=122, Percent_Identity=36.0655737704918, Blast_Score=91, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 16852; Mature: 16721

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIRVDFYLLASSLPESRWLVACRLIEKAYTKGHTIFVFCDNQQQAEYLDELLWTFKDD
CCCEEEHHEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCC
SFIPHNLQGEGPEPPPPVQIGYQKEPRGFTDILLNLSTNIPIFYTRFKRVIELVSNVEHE
CCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHCCHHH
KEVSRLHYKKYRNKGCALHTHSIE
HHHHHHHHHHHCCCCCEEEECCCC
>Mature Secondary Structure 
SPIRVDFYLLASSLPESRWLVACRLIEKAYTKGHTIFVFCDNQQQAEYLDELLWTFKDD
CCEEEHHEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCC
SFIPHNLQGEGPEPPPPVQIGYQKEPRGFTDILLNLSTNIPIFYTRFKRVIELVSNVEHE
CCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHCCHHH
KEVSRLHYKKYRNKGCALHTHSIE
HHHHHHHHHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9864319; 10984043 [H]