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The map label for this gene is pepA [H]

Identifier: 54295470

GI number: 54295470

Start: 2919449

End: 2920900

Strand: Direct

Name: pepA [H]

Synonym: lpl2556

Alternate gene names: 54295470

Gene position: 2919449-2920900 (Clockwise)

Preceding gene: 54295466

Following gene: 54295471

Centisome position: 87.26

GC content: 42.63

Gene sequence:

>1452_bases
ATGAATTATGGATTAACTCATACCCCCTCATTAAACATGAGCGAATGTCTGGTGTTAGGCGTTTTTTCAGATTTGGCGCT
ACCAGATTTTGCAACTGCAATTGATAATGAACAGCAAGGGCTGATTAAAAAACTTTGCCAGAGAGTCCCTGAACCAGGAA
ATACTGTATGGCAAACTGATGTTGAAGGACATAGCCTATTAATCATTCAGTGTGGCAAAAAGGAAGGGTTTAGCGCTAAT
TCACTCCAAAAACGTGTAGGAGAAATTACCGAAGCATTAATTAAACAGCGTTTCTCTTCTGCCACCGTATGCTTGCCTCG
GTTAAATCAGGAATCTTCTGAATGGCAGTTAGAGCAAATGATTGTTCAAATCGATAATTTACGATATCAACTTCTTGATT
TTAAAACGAAACATGCAAAAAGCCATAAATTGGAGTCGGTAATATTCCATCTACCTGGAGCTACTGAAAAAAGCCTTGAA
ATGGCCAAAGCCATTGTTAGCGGAGTTGAATTCTGCCGTGATTTAGCGAATATGCCGGCCAATATTTGTACTCCGACTTA
CCTTGGTGAGCAAGCCATTTCATTATCCAAACAATTCGACCAAATAAGCTGTCAAGTTATGGGGCCAGAAGAAATAAAAG
AAATGGGGATGGGCGCATTATTAGCCGTTGCCCAGGGAAGTGACCAACCCCCAAGATTGATAGACATTCATTATCACGGT
AACAAAAACTCAGCACCGGTCATTCTTGTAGGGAAAGGAATTACTTTTGACTCAGGGGGCTTATCTATAAAGCCGGCCAA
CGCTATGGATGAAATGAAATACGATATGTCTGGCGCTGCCAGTGTGCTGGGAGTTATAAAAGCCTGTGCTTTGCTGAAAT
TGCCAATTAATCTTATTGGCATTATAGCCAGTGCTGAAAATTTGATAAGTGGCTCCGCTGTAAAATCAGGAGACATTGTA
ACCACCATGTCAGGACAAACAGTCGAAATCATTAATACCGATGCGGAGGGTCGATTAGTGCTAGCAGACGCTTTGACTTA
CGCGGAGCGATATAATCCTGATTTTGTAATCGATATTGCTACTTTAACAGGAGCGATAATCGTTGCTTTGGGCAATATAG
CCACTGGCTATATGACTAGAGATGAACAGCTGGCCAAATCAATCGAACGTGCCGCTAATGAAAGCCAGGATAAAGTCTGG
CGTATGCCACTGGATGAGGCCTATCAAGATGCTTTGGAAAGCCCATTGGCTGATATGATCAACGCCGGCTTTGATCGCAG
TGCAGGAAGTATTACTGCCGCCTGTTTCTTATCACGGTTTACTGAAAAATATCGTTGGGCCCATTTGGACATCGCAGGAA
CAGCCTGGATTTCTGGAAAGAAGCGTAATGCAACAGGGCGTCCTGTTCCTTTATTAATTCAATTATTGCGCCATGTCGCC
AATTCGCGTTGA

Upstream 100 bases:

>100_bases
TTGATTTAAAACAGATGATTAAAACAGAATTTTTCATTCAAATGCTTATCCAATTTAGGTAAACTAGTTGTCTTTCTCAA
GCGGTGCAGGAAAAAATATT

Downstream 100 bases:

>100_bases
TTTTTACTTATTAGCCAGCAGCCTTCCAGAATCTCGCTGGTTGGTTGCTTGTCGTTTAATAGAAAAAGCCTATACCAAAG
GACATACTATTTTTGTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYGLTHTPSLNMSECLVLGVFSDLALPDFATAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQCGKKEGFSAN
SLQKRVGEITEALIKQRFSSATVCLPRLNQESSEWQLEQMIVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLE
MAKAIVSGVEFCRDLANMPANICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHG
NKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLISGSAVKSGDIV
TTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVW
RMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVA
NSR

Sequences:

>Translated_483_residues
MNYGLTHTPSLNMSECLVLGVFSDLALPDFATAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQCGKKEGFSAN
SLQKRVGEITEALIKQRFSSATVCLPRLNQESSEWQLEQMIVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLE
MAKAIVSGVEFCRDLANMPANICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHG
NKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLISGSAVKSGDIV
TTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVW
RMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVA
NSR
>Mature_483_residues
MNYGLTHTPSLNMSECLVLGVFSDLALPDFATAIDNEQQGLIKKLCQRVPEPGNTVWQTDVEGHSLLIIQCGKKEGFSAN
SLQKRVGEITEALIKQRFSSATVCLPRLNQESSEWQLEQMIVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLE
MAKAIVSGVEFCRDLANMPANICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHG
NKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIGIIASAENLISGSAVKSGDIV
TTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIATLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVW
RMPLDEAYQDALESPLADMINAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVA
NSR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=510, Percent_Identity=36.6666666666667, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI47155554, Length=361, Percent_Identity=33.7950138504155, Blast_Score=146, Evalue=4e-35,
Organism=Escherichia coli, GI1790710, Length=486, Percent_Identity=43.4156378600823, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI87082123, Length=324, Percent_Identity=40.4320987654321, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17556903, Length=294, Percent_Identity=36.3945578231293, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=250, Percent_Identity=30.8, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355725, Length=312, Percent_Identity=35.8974358974359, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24661038, Length=312, Percent_Identity=35.5769230769231, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI20129969, Length=318, Percent_Identity=36.4779874213836, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI161077148, Length=320, Percent_Identity=35.3125, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI20130057, Length=320, Percent_Identity=35.3125, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI21355645, Length=318, Percent_Identity=34.5911949685535, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662223, Length=318, Percent_Identity=34.5911949685535, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662227, Length=362, Percent_Identity=31.4917127071823, Blast_Score=178, Evalue=8e-45,
Organism=Drosophila melanogaster, GI19922386, Length=319, Percent_Identity=33.8557993730408, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129963, Length=318, Percent_Identity=32.7044025157233, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21357381, Length=330, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI221379063, Length=330, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI221379062, Length=330, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646701, Length=185, Percent_Identity=30.2702702702703, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646703, Length=185, Percent_Identity=30.2702702702703, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358201, Length=185, Percent_Identity=30.2702702702703, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52526; Mature: 52526

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYGLTHTPSLNMSECLVLGVFSDLALPDFATAIDNEQQGLIKKLCQRVPEPGNTVWQTD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEC
VEGHSLLIIQCGKKEGFSANSLQKRVGEITEALIKQRFSSATVCLPRLNQESSEWQLEQM
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHH
IVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLEMAKAIVSGVEFCRDLANMPA
HHHHHCCCEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
NICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHG
HHCCCHHHCHHHHHHHHHHCCCEEEEECHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEC
NKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIG
CCCCCCEEEEECCEEECCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHH
IIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIA
HHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCEEEEHH
TLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQDALESPLADMI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHEECCCHHHHHHHHHHCHHHHHH
NAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVA
HCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECEEEEECCCCCCCCCCCHHHHHHHHHHHH
NSR
CCC
>Mature Secondary Structure
MNYGLTHTPSLNMSECLVLGVFSDLALPDFATAIDNEQQGLIKKLCQRVPEPGNTVWQTD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEC
VEGHSLLIIQCGKKEGFSANSLQKRVGEITEALIKQRFSSATVCLPRLNQESSEWQLEQM
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHH
IVQIDNLRYQLLDFKTKHAKSHKLESVIFHLPGATEKSLEMAKAIVSGVEFCRDLANMPA
HHHHHCCCEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
NICTPTYLGEQAISLSKQFDQISCQVMGPEEIKEMGMGALLAVAQGSDQPPRLIDIHYHG
HHCCCHHHCHHHHHHHHHHCCCEEEEECHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEC
NKNSAPVILVGKGITFDSGGLSIKPANAMDEMKYDMSGAASVLGVIKACALLKLPINLIG
CCCCCCEEEEECCEEECCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHH
IIASAENLISGSAVKSGDIVTTMSGQTVEIINTDAEGRLVLADALTYAERYNPDFVIDIA
HHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCEEEEHH
TLTGAIIVALGNIATGYMTRDEQLAKSIERAANESQDKVWRMPLDEAYQDALESPLADMI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHEECCCHHHHHHHHHHCHHHHHH
NAGFDRSAGSITAACFLSRFTEKYRWAHLDIAGTAWISGKKRNATGRPVPLLIQLLRHVA
HCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECEEEEECCCCCCCCCCCHHHHHHHHHHHH
NSR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA