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The map label for this gene is acdA [H]

Identifier: 54294711

GI number: 54294711

Start: 2000819

End: 2001988

Strand: Direct

Name: acdA [H]

Synonym: lpl1788

Alternate gene names: 54294711

Gene position: 2000819-2001988 (Clockwise)

Preceding gene: 54294703

Following gene: 54294712

Centisome position: 59.8

GC content: 40.34

Gene sequence:

>1170_bases
ATGTCACTCATGTACACAGGCTTAGACTTTCAACTGGGCGAAACATATGACATGTTACGAGACAGCGTCAACCAATTTGC
CCAAACTGAAATAGCTCCTTTAGCTGCACAAATCGATGAGCAAAATACTTTTCCTAATCATCTCTGGAGAAAACTGGGAG
AAATGGGATTACTTGGCATCACAGTAAGTGAAGAATATGGTGGTGCCAATATGGGATACCTAGCGCATACCATAGCAATG
GAAGAAATTTCCAGAGCCTCCGCATCAGTTGGTTTAAGTTATGGCGCGCACTCTAATTTGTGTGTCAATCAAATTTTTTT
AAATGGAAACAATGAGCAAAAGCAAAAATATTTGCCTAAACTTATAAGCGGTGAATATATTGGTGCTTTGGCAATGAGTG
AGTCCAACTCAGGGTCCGATGTAGTCAGTATGCAATTACAAGCCCGTTCTGCTGGAGACAAATATATTCTTGACGGCACA
AAAATGTGGATAACCAATGGTCCTGATGCGGATGTTTTGGTTGTCTATGCTAAAACAGACAAGCAGGCTGGAAGCAAAGG
GATTACTGCCTTTATTATCGAAAAAGGAATGCCCGGGTTTAAAACAGCGCAAAAACTGGACAAGCTTGGTATGCGTGGGT
CAAACACATGTGAATTGGTATTTGATCAATGTGAAGTACCTTCTGAAAATGTTCTGGGAACAGTAAATCAAGGGGTCAAG
GTATTAATGAGCGGCTTGGATTATGAACGCACAATTCTTGCTGCCGGACCAGTTGGAATTATGCAAGCTTGTATGGATGT
TGTATTACCCTATGTCCATGAACGAAAGCAATTTAATCAGGCAATAGGTGAGTTTCAATTTATTCAAGGCAAACTTGCTG
ATATGTACACTGATTTGAATGCTTGCAGAGCTTATCTGTATGCCGTTGCCAAAGCTTGTGACAACGGTAGGGTTAGTCGT
AAGGATGCTGCAGGAGTTATTTTATATACTGCAGAAAAAGCAACACAAATGGCTTTACAGTCAATACAGATTCTTGGGGG
AAATGGTTATATTAATGAATATCCTACGGGACGCTTATTAAGGGATGCGAAGTTGTATGAAATTGGGGCAGGCACTTCTG
AAATAAGAAGAATGCTAATTGGTCGTGAACTTTTTAAAGAAACAGCATAA

Upstream 100 bases:

>100_bases
AATGTATCAGTGGGTTAAAAAGATTGTCTTGGAAATAAACAGGAAGGTGACAAGTACGCTTCATTTGGGTATAGTCTAGC
GTATTTATCAACATAACAGG

Downstream 100 bases:

>100_bases
GGAATGAGACAATGGAACATAATGATGTCGTGATAGTCGCAGCAAAAAGAACACCAATGGGAGCTATGCTAGGCAATTTA
TCTGCACTTTCCTCCCCAGA

Product: hypothetical protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSLMYTGLDFQLGETYDMLRDSVNQFAQTEIAPLAAQIDEQNTFPNHLWRKLGEMGLLGITVSEEYGGANMGYLAHTIAM
EEISRASASVGLSYGAHSNLCVNQIFLNGNNEQKQKYLPKLISGEYIGALAMSESNSGSDVVSMQLQARSAGDKYILDGT
KMWITNGPDADVLVVYAKTDKQAGSKGITAFIIEKGMPGFKTAQKLDKLGMRGSNTCELVFDQCEVPSENVLGTVNQGVK
VLMSGLDYERTILAAGPVGIMQACMDVVLPYVHERKQFNQAIGEFQFIQGKLADMYTDLNACRAYLYAVAKACDNGRVSR
KDAAGVILYTAEKATQMALQSIQILGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFKETA

Sequences:

>Translated_389_residues
MSLMYTGLDFQLGETYDMLRDSVNQFAQTEIAPLAAQIDEQNTFPNHLWRKLGEMGLLGITVSEEYGGANMGYLAHTIAM
EEISRASASVGLSYGAHSNLCVNQIFLNGNNEQKQKYLPKLISGEYIGALAMSESNSGSDVVSMQLQARSAGDKYILDGT
KMWITNGPDADVLVVYAKTDKQAGSKGITAFIIEKGMPGFKTAQKLDKLGMRGSNTCELVFDQCEVPSENVLGTVNQGVK
VLMSGLDYERTILAAGPVGIMQACMDVVLPYVHERKQFNQAIGEFQFIQGKLADMYTDLNACRAYLYAVAKACDNGRVSR
KDAAGVILYTAEKATQMALQSIQILGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFKETA
>Mature_388_residues
SLMYTGLDFQLGETYDMLRDSVNQFAQTEIAPLAAQIDEQNTFPNHLWRKLGEMGLLGITVSEEYGGANMGYLAHTIAME
EISRASASVGLSYGAHSNLCVNQIFLNGNNEQKQKYLPKLISGEYIGALAMSESNSGSDVVSMQLQARSAGDKYILDGTK
MWITNGPDADVLVVYAKTDKQAGSKGITAFIIEKGMPGFKTAQKLDKLGMRGSNTCELVFDQCEVPSENVLGTVNQGVKV
LMSGLDYERTILAAGPVGIMQACMDVVLPYVHERKQFNQAIGEFQFIQGKLADMYTDLNACRAYLYAVAKACDNGRVSRK
DAAGVILYTAEKATQMALQSIQILGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFKETA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=65.0666666666667, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI226958414, Length=337, Percent_Identity=68.2492581602374, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=41.4893617021277, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI4501859, Length=391, Percent_Identity=34.2710997442455, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=35.2631578947368, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=35.2631578947368, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=38.1471389645777, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=31.8059299191375, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=33.8582677165354, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=33.8582677165354, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI7656849, Length=366, Percent_Identity=31.4207650273224, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=31.0526315789474, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI7669494, Length=350, Percent_Identity=32, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI48976061, Length=282, Percent_Identity=21.2765957446809, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI211971008, Length=282, Percent_Identity=21.2765957446809, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=20.5673758865248, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=27.0341207349081, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=29.5039164490862, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=26.7148014440433, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081702, Length=332, Percent_Identity=24.0963855421687, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=64.2105263157895, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.9580052493438, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=34.7708894878706, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=389, Percent_Identity=33.4190231362468, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=34.2857142857143, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71990804, Length=303, Percent_Identity=36.3036303630363, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=367, Percent_Identity=31.0626702997275, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=33.2378223495702, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.5281385281385, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=29.023746701847, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=33.0909090909091, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=29.9465240641711, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=34.5070422535211, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=28.494623655914, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=27.6150627615063, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=283, Percent_Identity=26.5017667844523, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=283, Percent_Identity=26.5017667844523, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=63.3507853403141, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=39.9470899470899, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=39.6276595744681, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=34.6560846560847, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=35.2480417754569, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281363737, Length=359, Percent_Identity=33.1476323119777, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=29.5811518324607, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42515; Mature: 42384

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMYTGLDFQLGETYDMLRDSVNQFAQTEIAPLAAQIDEQNTFPNHLWRKLGEMGLLGI
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEE
TVSEEYGGANMGYLAHTIAMEEISRASASVGLSYGAHSNLCVNQIFLNGNNEQKQKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHH
LISGEYIGALAMSESNSGSDVVSMQLQARSAGDKYILDGTKMWITNGPDADVLVVYAKTD
HHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCEEEEEECCCCCCEEEEEEECC
KQAGSKGITAFIIEKGMPGFKTAQKLDKLGMRGSNTCELVFDQCEVPSENVLGTVNQGVK
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCHHHHHHH
VLMSGLDYERTILAAGPVGIMQACMDVVLPYVHERKQFNQAIGEFQFIQGKLADMYTDLN
HHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACRAYLYAVAKACDNGRVSRKDAAGVILYTAEKATQMALQSIQILGGNGYINEYPTGRLL
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHEECCCCCCCCCCCCCHH
RDAKLYEIGAGTSEIRRMLIGRELFKETA
HCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLMYTGLDFQLGETYDMLRDSVNQFAQTEIAPLAAQIDEQNTFPNHLWRKLGEMGLLGI
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEE
TVSEEYGGANMGYLAHTIAMEEISRASASVGLSYGAHSNLCVNQIFLNGNNEQKQKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHH
LISGEYIGALAMSESNSGSDVVSMQLQARSAGDKYILDGTKMWITNGPDADVLVVYAKTD
HHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCEEEEEECCCCCCEEEEEEECC
KQAGSKGITAFIIEKGMPGFKTAQKLDKLGMRGSNTCELVFDQCEVPSENVLGTVNQGVK
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCHHHHHHH
VLMSGLDYERTILAAGPVGIMQACMDVVLPYVHERKQFNQAIGEFQFIQGKLADMYTDLN
HHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACRAYLYAVAKACDNGRVSRKDAAGVILYTAEKATQMALQSIQILGGNGYINEYPTGRLL
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHEECCCCCCCCCCCCCHH
RDAKLYEIGAGTSEIRRMLIGRELFKETA
HCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]