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The map label for this gene is fabG [C]

Identifier: 54294457

GI number: 54294457

Start: 1701000

End: 1701641

Strand: Direct

Name: fabG [C]

Synonym: lpl1526

Alternate gene names: 54294457

Gene position: 1701000-1701641 (Clockwise)

Preceding gene: 54294456

Following gene: 54294458

Centisome position: 50.84

GC content: 36.29

Gene sequence:

>642_bases
TTGAAGACTCTCGTCATAACAGGAATCAGTAGAGGTATAGGCCTGGAAATTGCTAGAATTTTCCTTGACAAAGATTGGAT
GGTTATTGGTACTTCCACCAGCGGATATTCTCCTATAAAACATAAAAACCTACGCACATACAAGTTAGACCTAGCCATTT
CGGAGCACATCGATGCATTTGCAAAAAATTTACCTAAAATTGATGTACTGATTAATAATGCCGCCGTGTTGCTTGAAGAG
TGGAATGAAGAAAAAATTAATATGTCTTTATTGAAAAAAACCTTTGCAATCAACCTGTTTGGTACAGTTGAGTTAACTGA
AAAATGTATTTCCAAGTTCAATGATGGCGCACAAATCATTAATATCTCTTCAGGGTGGGGAGCATTTAGTTCCAATAATT
CCCCCTTTCAACCACATTATAAAATGTCAAAAGTCAGTTTGAATATGTATACTAAATTGCTTGCGGGAAGACTTCCCCAA
ATAACTGTATCCAGTTTTGATCCAGGTTGGGTTAAAACAAACATGGGAACACAAAATGCAAAAAAACTTCCCAGTGAAAC
AGCACTGGAAATCTATGAGCTGATTAGTATGAAGAAAAAAAGCGGCTATTTTTGGTTTAATGGAAAACCAAGGGATTGGT
AG

Upstream 100 bases:

>100_bases
GATTGAATTATAAAAATTTTTTTAACAAAGAGATTTAGTTTTGCAAAAAATTAAAAGATCAATTATTTTGATTTTACAAG
CCACGGATAGAAGATTTAAA

Downstream 100 bases:

>100_bases
CCAGTTAAATTTCAGTTATTCTCAGCTATGAAATAAAGCATCAAAGGAGTGACAAACGTGAGTTTCGATTTTATAAAATC
AATATGGATTGCAGCTCTTA

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: Short Chain Dehydrogenase; Oxidoreductase Short Chain Dehydrogenase/Reductase Family; Short-Chain Dehydrogenase/Reductase; Short Chain Dehydrogenase/Reductase Family Oxidoreductase; Dehydrogenase; Oxidoreductase; Short Chain Oxidoreductase; Short-Chain Dehydrogenase/Reductase Sdr; 3-Oxoacyl-[Acyl-Carrier Protein] Reductase; Short-Chain Dehydrogenase/Reductase Superfamily Protein; Oxidoreductase Protein; 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase; Carbonyl Reductase; Short-Chain Dehydrogenase; Short-Chain Dehydrogenase Oxidoreductase; Short-Chain Dehydrogenase/Reductase Family Protein; CsgA Protein; Short Chain Dehydrogenase Family Protein; Short-Chain Type Dehydrogenase; Short-Chain Dehydrogenase/Reductase Family Oxidoreductase; SDR Family Dehydrogenase/Reductase; Short-Chain Dehydrogenase/Reductase Superfamily; 2-Hydroxycyclohexanecarboxyl-CoA Dehydrogenase; Short-Chain Dehydrogenase Family Protein; Gluconate 5-Dehydrogenase; Short Chanin Dehydrogenase/ Reductase; Oxidoreductase Short-Chain Dehydrogenase; 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; C-Factor Protein; 3-Ketoacyl-(Acyl-Carrier-Protein) Reductase; NADPH-Dependent Carbonyl Reductase; KR Domain Superfamily; Dehydrogenase Protein; Short-Chain Alcohol Dehydrogenase; Retinol Dehydrogenase; Short-Chain Alcohol Dehydrogenase-Like Protein; Cis-2 3-Dihydrobiphenyl-2 3-Diol Dehydrogenase; Short-Chain Dehydrogenase/Reductase SDR Family; Estradiol; 20-Beta-Hydroxysteroid Dehydrogenase; Oxidoreductase Short-Chain Dehydrogenase/Reductase Family; Short-Chain Alcohol Dehydrogenase Like Protein; Oxidoreductase Short Chain Dehydrogenase/Reductase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKTLVITGISRGIGLEIARIFLDKDWMVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEE
WNEEKINMSLLKKTFAINLFGTVELTEKCISKFNDGAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAGRLPQ
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW

Sequences:

>Translated_213_residues
MKTLVITGISRGIGLEIARIFLDKDWMVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEE
WNEEKINMSLLKKTFAINLFGTVELTEKCISKFNDGAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAGRLPQ
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
>Mature_213_residues
MKTLVITGISRGIGLEIARIFLDKDWMVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEE
WNEEKINMSLLKKTFAINLFGTVELTEKCISKFNDGAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAGRLPQ
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI17558994, Length=244, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=233, Percent_Identity=27.8969957081545, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559962, Length=212, Percent_Identity=30.6603773584906, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558992, Length=246, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=211, Percent_Identity=27.9620853080569, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559964, Length=210, Percent_Identity=31.9047619047619, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI72001658, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193207563, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=230, Percent_Identity=26.9565217391304, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532177, Length=213, Percent_Identity=30.9859154929577, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558996, Length=240, Percent_Identity=28.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=236, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=195, Percent_Identity=29.2307692307692, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640547, Length=251, Percent_Identity=28.2868525896414, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24015; Mature: 24015

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLVITGISRGIGLEIARIFLDKDWMVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
CCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEEEHHHHHHHH
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCISKFNDGAQII
HHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCCCCEEE
NISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAGRLPQITVSSFDPGWVKTNMGTQNA
EECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCHH
KKLPSETALEIYELISMKKKSGYFWFNGKPRDW
HHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MKTLVITGISRGIGLEIARIFLDKDWMVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
CCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEEEHHHHHHHH
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCISKFNDGAQII
HHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCCCCEEE
NISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAGRLPQITVSSFDPGWVKTNMGTQNA
EECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCHH
KKLPSETALEIYELISMKKKSGYFWFNGKPRDW
HHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA