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The map label for this gene is aceE [H]

Identifier: 54294453

GI number: 54294453

Start: 1693773

End: 1696436

Strand: Direct

Name: aceE [H]

Synonym: lpl1522

Alternate gene names: 54294453

Gene position: 1693773-1696436 (Clockwise)

Preceding gene: 54294452

Following gene: 54294454

Centisome position: 50.63

GC content: 40.99

Gene sequence:

>2664_bases
ATGACCAATGAAACAAATTTAGATCTGGATCCAATAGAAACGCGTGAATGGCTGGATGCCCTACAAGCTGTACTCTTTAA
TGATGGTCCTGAACGTACTGCATTCCTTTTGCAGCAGCTTCTTAATAAAGCGAACGCCGAGGGGGTTAAACTAACCAGCT
CAATTAATACTCCCTACAGAAACACTATAAAACCTCACGAAGAAAAACAAATGCCTCCCGATGAGGGTATTGGAAAGCGC
ATCAATGCATTAATCAGATGGAACGCTGTTGCAATGGTACTTAGGGCAGGTAAATACGCGCCAGAGCTTGGCGGCCATAT
CGCTTCTTATGCATCTGCATCAACGTTATATGAAACTGGATTTAACTATTTTTTTAAGGGACAGAAAGGTGAAAACGGAG
GGGACTTGCTTTATATTCAAGGCCACTCGGCTCCAGGCATTTATGCCAGAGCATTTCTTGAAGGCCGATTAACAGAGAAA
CAACTTGAAAAATTCCGGCAAGAAGTAGAGGTAGATGGTTTATCTTCCTACCCACACCCTTGGCTAATGAACGATTTTTG
GCAATTTCCCACTGTATCCATGGGCTTAGGCCCTTTGCAAGCTATCTATCAAGCTCGCTTTCTAAAATATCTTGAGAACC
GGGGACTGATCAAAGCTGAGGGTAGAAAAGTATGGGCATTTTTGGGTGATGGCGAGATGGATGAGCCTGAATCAGTCGGG
GCACTCAGTATCGCAGCACGAGAAAAGCTGGATAATCTCATTTTTGTAGTCAATTGCAATTTACAAAGACTTGATGGGCC
TGTGCGTGGTAACGGTAAAATCATTCAAGAACTTGAAGGCCTATTTCGAGGAGCTGGATGGAACGTTATTAAGGTCATCT
GGGGAGGCCGTTGGGATCCATTATTTGCCCGTGATAATCAAGGCTGGCTACAGAAAAGGATGGAAGAATGTCTGGATGGA
GATTATCAATCCTACAAAGCGAACGATGGATCGTATGTAAGACAACATTTCTTTAATCAATATCCAGAATTAAAGAAAAT
GGTTGAAAATATGTCTGATGAGGAAATCTGGCGATTAAATCGTGGTGGCCATGATCCTCAAAAAGTATATGCAGCTTATG
CCAGAGCGGTTGAACACAAGGGAACTCCAACAGTTATCCTTGCAAAAACCATCAAGGGCTACGGGATGGGAGCTGCTGGT
GAGGGACAAAACATTACTCATCAACAGAAAAAAATGACCATAGATCAACTAAAAGCTTTCAGAGATCGATTTAATATTCC
AATCAGCGATGACAAAATTGCTGATATTCCTTTCTATAAACCTGATGACGACAGTCCCGAAATCAAGTATATAAAAAAGC
AAAGGGAAGCCTTGGGCGGTTATTTGCCACACCGTTCAACTGAAGTAGAACAGTTAAAAATACCTGATTTAGGAGAGTTT
TCCAGTATTACCAAGGGATTAGGAGATAGAGAAATCTCGACTACTATGGCATTTGTGCGAATTCTTTCAGTTCTACTCAA
AAATAAAGACATTAATTCCAGAATAGTCCCCATAGTACCAGATGAATGCAGAACATTCGGTATGGAAGGATTATTCAGAC
AAATTGGAATTTATTCTCCCGTAGGTCAACTTTATACTCCCGTAGATCATGAACAAGTGATGTATTACCGAGAAGCAGTT
GACGGGCAGATTCTTGAAGAAGGCATTAATGAAGCTGGGGCGTTTTGTTCGTGGATTGCTGCCGCAACCTCTTACAGTTC
AAATAAGCTGACAATGATTCCATTTTACATTTATTACTCTATGTTTGGTTTCCAACGCATTGGTGATTTAGCATGGGCGG
CAGGAGATATGCAAGCGAGAGGATTTCTGCTCGGTGGAACCGCTGGACGAACAACGTTGGCAGGAGAAGGATTGCAACAC
CAAGATGGACATAGTCATGTCTTGGCATCAACAATACCCAATTGTATTTCTTATGATCCCACATACGCCTATGAATTAGC
AGTTATCATCCAAAATGGATTGCACCGTATGTATGAAAAACAGGAAAACGTGTTTTATTACATTACTATTATGAATGAAA
ACTACTCTCATCCCGATATGCCTGCAGGAGTAGAGGAAGGTATTATCAAAGGAATGTATCTCTTAAAAGAAAATAAGAAA
AAATCAAAAAACCATGTCCAACTAATGGGATGCGGCACTATTTTGCGTGAAGTTATCAAAGCCGCAGAGATGTTGGAAGA
GGATTTTTCAATTACATCGGATATCTGGAGTGTAACTAGCTTCAATGAGCTACGTAAAGAAGGTTTGGCTGTAGAGCGAT
ACAATAACATGCACCCCCAAAATAAGCCTCAGGAAAGTTATGTGACATCTCAATTAAAAGGACGTCGTGGACCTGTTATT
GCCTCAACTGACTATATGCGTATTTATGCAGATCAGATCAGGCCTTTTGTTCCTAATCGATATATTACCCTAGGTACAGA
CGGTTACGGCAGAAGTGATACCCGTACACAACTACGTCATTTCTTTGAAGTTGATGCAAAATTTATAGTGTTGGCGGCAT
TAAATGCACTTGTAGCTGAAGGTAGTCTTGATAAAGCAAAAATTGTCGATGCCATGAAACGTTACAATATTAATCAAGAC
AAATTGGATCCAATGACCCATTAG

Upstream 100 bases:

>100_bases
TTTTAATGCATGTAATCAAGGTTGTTCTGGTGTAATTCAGAAAAGATTACAACCCGTACCATACTGTTCATAAAATTATT
GATTGTTGGGGAACTATTTC

Downstream 100 bases:

>100_bases
TTAAACAATTAATCAGAACAGAAGATAGTTCCGGTTTAACTGAGTGCTGAGGAAAATATGACAAAAGAAAGTGAAATTAA
AATTCCTGATATCGGTGGTG

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MTNETNLDLDPIETREWLDALQAVLFNDGPERTAFLLQQLLNKANAEGVKLTSSINTPYRNTIKPHEEKQMPPDEGIGKR
INALIRWNAVAMVLRAGKYAPELGGHIASYASASTLYETGFNYFFKGQKGENGGDLLYIQGHSAPGIYARAFLEGRLTEK
QLEKFRQEVEVDGLSSYPHPWLMNDFWQFPTVSMGLGPLQAIYQARFLKYLENRGLIKAEGRKVWAFLGDGEMDEPESVG
ALSIAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGLFRGAGWNVIKVIWGGRWDPLFARDNQGWLQKRMEECLDG
DYQSYKANDGSYVRQHFFNQYPELKKMVENMSDEEIWRLNRGGHDPQKVYAAYARAVEHKGTPTVILAKTIKGYGMGAAG
EGQNITHQQKKMTIDQLKAFRDRFNIPISDDKIADIPFYKPDDDSPEIKYIKKQREALGGYLPHRSTEVEQLKIPDLGEF
SSITKGLGDREISTTMAFVRILSVLLKNKDINSRIVPIVPDECRTFGMEGLFRQIGIYSPVGQLYTPVDHEQVMYYREAV
DGQILEEGINEAGAFCSWIAAATSYSSNKLTMIPFYIYYSMFGFQRIGDLAWAAGDMQARGFLLGGTAGRTTLAGEGLQH
QDGHSHVLASTIPNCISYDPTYAYELAVIIQNGLHRMYEKQENVFYYITIMNENYSHPDMPAGVEEGIIKGMYLLKENKK
KSKNHVQLMGCGTILREVIKAAEMLEEDFSITSDIWSVTSFNELRKEGLAVERYNNMHPQNKPQESYVTSQLKGRRGPVI
ASTDYMRIYADQIRPFVPNRYITLGTDGYGRSDTRTQLRHFFEVDAKFIVLAALNALVAEGSLDKAKIVDAMKRYNINQD
KLDPMTH

Sequences:

>Translated_887_residues
MTNETNLDLDPIETREWLDALQAVLFNDGPERTAFLLQQLLNKANAEGVKLTSSINTPYRNTIKPHEEKQMPPDEGIGKR
INALIRWNAVAMVLRAGKYAPELGGHIASYASASTLYETGFNYFFKGQKGENGGDLLYIQGHSAPGIYARAFLEGRLTEK
QLEKFRQEVEVDGLSSYPHPWLMNDFWQFPTVSMGLGPLQAIYQARFLKYLENRGLIKAEGRKVWAFLGDGEMDEPESVG
ALSIAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGLFRGAGWNVIKVIWGGRWDPLFARDNQGWLQKRMEECLDG
DYQSYKANDGSYVRQHFFNQYPELKKMVENMSDEEIWRLNRGGHDPQKVYAAYARAVEHKGTPTVILAKTIKGYGMGAAG
EGQNITHQQKKMTIDQLKAFRDRFNIPISDDKIADIPFYKPDDDSPEIKYIKKQREALGGYLPHRSTEVEQLKIPDLGEF
SSITKGLGDREISTTMAFVRILSVLLKNKDINSRIVPIVPDECRTFGMEGLFRQIGIYSPVGQLYTPVDHEQVMYYREAV
DGQILEEGINEAGAFCSWIAAATSYSSNKLTMIPFYIYYSMFGFQRIGDLAWAAGDMQARGFLLGGTAGRTTLAGEGLQH
QDGHSHVLASTIPNCISYDPTYAYELAVIIQNGLHRMYEKQENVFYYITIMNENYSHPDMPAGVEEGIIKGMYLLKENKK
KSKNHVQLMGCGTILREVIKAAEMLEEDFSITSDIWSVTSFNELRKEGLAVERYNNMHPQNKPQESYVTSQLKGRRGPVI
ASTDYMRIYADQIRPFVPNRYITLGTDGYGRSDTRTQLRHFFEVDAKFIVLAALNALVAEGSLDKAKIVDAMKRYNINQD
KLDPMTH
>Mature_886_residues
TNETNLDLDPIETREWLDALQAVLFNDGPERTAFLLQQLLNKANAEGVKLTSSINTPYRNTIKPHEEKQMPPDEGIGKRI
NALIRWNAVAMVLRAGKYAPELGGHIASYASASTLYETGFNYFFKGQKGENGGDLLYIQGHSAPGIYARAFLEGRLTEKQ
LEKFRQEVEVDGLSSYPHPWLMNDFWQFPTVSMGLGPLQAIYQARFLKYLENRGLIKAEGRKVWAFLGDGEMDEPESVGA
LSIAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGLFRGAGWNVIKVIWGGRWDPLFARDNQGWLQKRMEECLDGD
YQSYKANDGSYVRQHFFNQYPELKKMVENMSDEEIWRLNRGGHDPQKVYAAYARAVEHKGTPTVILAKTIKGYGMGAAGE
GQNITHQQKKMTIDQLKAFRDRFNIPISDDKIADIPFYKPDDDSPEIKYIKKQREALGGYLPHRSTEVEQLKIPDLGEFS
SITKGLGDREISTTMAFVRILSVLLKNKDINSRIVPIVPDECRTFGMEGLFRQIGIYSPVGQLYTPVDHEQVMYYREAVD
GQILEEGINEAGAFCSWIAAATSYSSNKLTMIPFYIYYSMFGFQRIGDLAWAAGDMQARGFLLGGTAGRTTLAGEGLQHQ
DGHSHVLASTIPNCISYDPTYAYELAVIIQNGLHRMYEKQENVFYYITIMNENYSHPDMPAGVEEGIIKGMYLLKENKKK
SKNHVQLMGCGTILREVIKAAEMLEEDFSITSDIWSVTSFNELRKEGLAVERYNNMHPQNKPQESYVTSQLKGRRGPVIA
STDYMRIYADQIRPFVPNRYITLGTDGYGRSDTRTQLRHFFEVDAKFIVLAALNALVAEGSLDKAKIVDAMKRYNINQDK
LDPMTH

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=881, Percent_Identity=59.7048808172531, Blast_Score=1100, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100377; Mature: 100246

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNETNLDLDPIETREWLDALQAVLFNDGPERTAFLLQQLLNKANAEGVKLTSSINTPYR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
NTIKPHEEKQMPPDEGIGKRINALIRWNAVAMVLRAGKYAPELGGHIASYASASTLYETG
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCC
FNYFFKGQKGENGGDLLYIQGHSAPGIYARAFLEGRLTEKQLEKFRQEVEVDGLSSYPHP
CCEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
WLMNDFWQFPTVSMGLGPLQAIYQARFLKYLENRGLIKAEGRKVWAFLGDGEMDEPESVG
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCCCCCCC
ALSIAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGLFRGAGWNVIKVIWGGRWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
LFARDNQGWLQKRMEECLDGDYQSYKANDGSYVRQHFFNQYPELKKMVENMSDEEIWRLN
CEECCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHC
RGGHDPQKVYAAYARAVEHKGTPTVILAKTIKGYGMGAAGEGQNITHQQKKMTIDQLKAF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RDRFNIPISDDKIADIPFYKPDDDSPEIKYIKKQREALGGYLPHRSTEVEQLKIPDLGEF
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEECCCCCCCH
SSITKGLGDREISTTMAFVRILSVLLKNKDINSRIVPIVPDECRTFGMEGLFRQIGIYSP
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHCHHHHHHHHCCCCC
VGQLYTPVDHEQVMYYREAVDGQILEEGINEAGAFCSWIAAATSYSSNKLTMIPFYIYYS
HHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHH
MFGFQRIGDLAWAAGDMQARGFLLGGTAGRTTLAGEGLQHQDGHSHVLASTIPNCISYDP
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEHHHHCCHHHCCCC
TYAYELAVIIQNGLHRMYEKQENVFYYITIMNENYSHPDMPAGVEEGIIKGMYLLKENKK
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
KSKNHVQLMGCGTILREVIKAAEMLEEDFSITSDIWSVTSFNELRKEGLAVERYNNMHPQ
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHCCCCCC
NKPQESYVTSQLKGRRGPVIASTDYMRIYADQIRPFVPNRYITLGTDGYGRSDTRTQLRH
CCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHH
FFEVDAKFIVLAALNALVAEGSLDKAKIVDAMKRYNINQDKLDPMTH
HHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure 
TNETNLDLDPIETREWLDALQAVLFNDGPERTAFLLQQLLNKANAEGVKLTSSINTPYR
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
NTIKPHEEKQMPPDEGIGKRINALIRWNAVAMVLRAGKYAPELGGHIASYASASTLYETG
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCC
FNYFFKGQKGENGGDLLYIQGHSAPGIYARAFLEGRLTEKQLEKFRQEVEVDGLSSYPHP
CCEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
WLMNDFWQFPTVSMGLGPLQAIYQARFLKYLENRGLIKAEGRKVWAFLGDGEMDEPESVG
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCCCCCCC
ALSIAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGLFRGAGWNVIKVIWGGRWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
LFARDNQGWLQKRMEECLDGDYQSYKANDGSYVRQHFFNQYPELKKMVENMSDEEIWRLN
CEECCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHC
RGGHDPQKVYAAYARAVEHKGTPTVILAKTIKGYGMGAAGEGQNITHQQKKMTIDQLKAF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RDRFNIPISDDKIADIPFYKPDDDSPEIKYIKKQREALGGYLPHRSTEVEQLKIPDLGEF
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEECCCCCCCH
SSITKGLGDREISTTMAFVRILSVLLKNKDINSRIVPIVPDECRTFGMEGLFRQIGIYSP
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHCHHHHHHHHCCCCC
VGQLYTPVDHEQVMYYREAVDGQILEEGINEAGAFCSWIAAATSYSSNKLTMIPFYIYYS
HHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHH
MFGFQRIGDLAWAAGDMQARGFLLGGTAGRTTLAGEGLQHQDGHSHVLASTIPNCISYDP
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEHHHHCCHHHCCCC
TYAYELAVIIQNGLHRMYEKQENVFYYITIMNENYSHPDMPAGVEEGIIKGMYLLKENKK
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
KSKNHVQLMGCGTILREVIKAAEMLEEDFSITSDIWSVTSFNELRKEGLAVERYNNMHPQ
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHCCCCCC
NKPQESYVTSQLKGRRGPVIASTDYMRIYADQIRPFVPNRYITLGTDGYGRSDTRTQLRH
CCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHH
FFEVDAKFIVLAALNALVAEGSLDKAKIVDAMKRYNINQDKLDPMTH
HHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]