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The map label for this gene is prpC [H]

Identifier: 54294427

GI number: 54294427

Start: 1665534

End: 1666652

Strand: Direct

Name: prpC [H]

Synonym: lpl1496

Alternate gene names: 54294427

Gene position: 1665534-1666652 (Clockwise)

Preceding gene: 54294426

Following gene: 54294428

Centisome position: 49.78

GC content: 39.23

Gene sequence:

>1119_bases
ATGAGTAGCAAAAGTGGAGGTTTAGCCGGTGTAGTTGCTGGTCAATCAGCAATTGCCACAGTTGGACTGGCAGGCAAGGG
ATTAAATTACAGAGGCTATTCAATAAATGATCTGGCTGAATATGCAAGTTTTGAGGAAGTTGCTTATCTGCTTCATTATG
GTGAACTTCCTACCCAAAAGGAACTTGATGTATACATAAAAAAGCTGGTTAACCTAAGACATATACCTGATGTGCTTAAA
ACGGTTTTGAAACTTATACCTAAAAATACTCACCCAATGGATGTACTGCGTACAGCATGTTCTTTTTTAGGCACTATCGA
ACCTGAAGAGAATTTTAAGCAACAATATGAAATAGCTGATCGTTTGCTAGCTCTTTTTCCGGGAATAATGTGTTATTGGT
ATACATATCATTTCAAAAATAAAGAAATCTCTGGCTTAAGTGAAGAAAACACAACAGGAGGACACTTTCTGGCGTTATTA
CACGGACGCAAGCCCAGCAAAATAGAAACCGATATGATGAATGTCTCTTTGATCTTGTATGCTGAACACGAATTTAACGC
TTCTACCTTTGCTGCAAGAGTTACAGCGGCAACACTGGCAGATTTTTATTCAGCAATCACAAGTGCTATAGGAACATTGC
GTGGTCCTTTGCATGGTGGCGCCAATGAAGCAGCTATGGAGTTAATTGAGCGCTTTAAAACCCCTGATGAAGCAGCGATA
GGCATAAAGCAAATGCTTGCCAGCAAAGAATTGATCATGGGATTTGGACATCGGGTTTATACAACTTGTGATCCACGCTC
AGATATTATTAAGAAATGGTCATTTAGATTGGGTGAAGAAAAGGGGAACCTACTTTTATACCATATTTCAGAACGTATTG
AAGAAATCATGTGGCAAGAGAAAAAACTATTTCCCAACCTGGATTTTTATAGTGCATCCGCTTATCATTACTGCGATATA
CCAACTCATTTGTTTACCCCAATTTTTGTGATGTCACGCATCACAGGATGGTCTGCGCACGTATTTGAGCAAAGAGCAAA
TAATAAACTAATAAGACCTACTTCCGAATATATAGGCCCAGATTCCAGGCCATTTCCTGCTATTGAAACACGAGGTTAA

Upstream 100 bases:

>100_bases
AAAATAATCAACCGCTTCAAAATTCAGTAATAATAAAAACATACGCAGCAATTTTGGCTGCACTAGAAATAAAAACTAGA
CCAACTGATGGAGGAAGAAA

Downstream 100 bases:

>100_bases
TATGCACAATTATGTAGAGGATAATGTTAAGCCACACTATGATCAGGTTATAGCAGATATAGCTGATTTTGTATTAAATA
AAGAAATTGATAGTGTGCAG

Product: 2-methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSSKSGGLAGVVAGQSAIATVGLAGKGLNYRGYSINDLAEYASFEEVAYLLHYGELPTQKELDVYIKKLVNLRHIPDVLK
TVLKLIPKNTHPMDVLRTACSFLGTIEPEENFKQQYEIADRLLALFPGIMCYWYTYHFKNKEISGLSEENTTGGHFLALL
HGRKPSKIETDMMNVSLILYAEHEFNASTFAARVTAATLADFYSAITSAIGTLRGPLHGGANEAAMELIERFKTPDEAAI
GIKQMLASKELIMGFGHRVYTTCDPRSDIIKKWSFRLGEEKGNLLLYHISERIEEIMWQEKKLFPNLDFYSASAYHYCDI
PTHLFTPIFVMSRITGWSAHVFEQRANNKLIRPTSEYIGPDSRPFPAIETRG

Sequences:

>Translated_372_residues
MSSKSGGLAGVVAGQSAIATVGLAGKGLNYRGYSINDLAEYASFEEVAYLLHYGELPTQKELDVYIKKLVNLRHIPDVLK
TVLKLIPKNTHPMDVLRTACSFLGTIEPEENFKQQYEIADRLLALFPGIMCYWYTYHFKNKEISGLSEENTTGGHFLALL
HGRKPSKIETDMMNVSLILYAEHEFNASTFAARVTAATLADFYSAITSAIGTLRGPLHGGANEAAMELIERFKTPDEAAI
GIKQMLASKELIMGFGHRVYTTCDPRSDIIKKWSFRLGEEKGNLLLYHISERIEEIMWQEKKLFPNLDFYSASAYHYCDI
PTHLFTPIFVMSRITGWSAHVFEQRANNKLIRPTSEYIGPDSRPFPAIETRG
>Mature_371_residues
SSKSGGLAGVVAGQSAIATVGLAGKGLNYRGYSINDLAEYASFEEVAYLLHYGELPTQKELDVYIKKLVNLRHIPDVLKT
VLKLIPKNTHPMDVLRTACSFLGTIEPEENFKQQYEIADRLLALFPGIMCYWYTYHFKNKEISGLSEENTTGGHFLALLH
GRKPSKIETDMMNVSLILYAEHEFNASTFAARVTAATLADFYSAITSAIGTLRGPLHGGANEAAMELIERFKTPDEAAIG
IKQMLASKELIMGFGHRVYTTCDPRSDIIKKWSFRLGEEKGNLLLYHISERIEEIMWQEKKLFPNLDFYSASAYHYCDIP
THLFTPIFVMSRITGWSAHVFEQRANNKLIRPTSEYIGPDSRPFPAIETRG

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=367, Percent_Identity=23.7057220708447, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786527, Length=371, Percent_Identity=50.6738544474393, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1786939, Length=386, Percent_Identity=30.0518134715026, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17555174, Length=365, Percent_Identity=22.7397260273973, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319850, Length=389, Percent_Identity=25.1928020565553, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324328, Length=364, Percent_Identity=23.9010989010989, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325257, Length=338, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356863, Length=369, Percent_Identity=25.2032520325203, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24640126, Length=376, Percent_Identity=22.6063829787234, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24640124, Length=376, Percent_Identity=22.6063829787234, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 41804; Mature: 41673

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKSGGLAGVVAGQSAIATVGLAGKGLNYRGYSINDLAEYASFEEVAYLLHYGELPTQK
CCCCCCCEEEEEECCHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
ELDVYIKKLVNLRHIPDVLKTVLKLIPKNTHPMDVLRTACSFLGTIEPEENFKQQYEIAD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RLLALFPGIMCYWYTYHFKNKEISGLSEENTTGGHFLALLHGRKPSKIETDMMNVSLILY
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHEEEEEEEE
AEHEFNASTFAARVTAATLADFYSAITSAIGTLRGPLHGGANEAAMELIERFKTPDEAAI
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHH
GIKQMLASKELIMGFGHRVYTTCDPRSDIIKKWSFRLGEEKGNLLLYHISERIEEIMWQE
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHH
KKLFPNLDFYSASAYHYCDIPTHLFTPIFVMSRITGWSAHVFEQRANNKLIRPTSEYIGP
HHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHCCC
DSRPFPAIETRG
CCCCCCCCCCCC
>Mature Secondary Structure 
SSKSGGLAGVVAGQSAIATVGLAGKGLNYRGYSINDLAEYASFEEVAYLLHYGELPTQK
CCCCCCEEEEEECCHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
ELDVYIKKLVNLRHIPDVLKTVLKLIPKNTHPMDVLRTACSFLGTIEPEENFKQQYEIAD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RLLALFPGIMCYWYTYHFKNKEISGLSEENTTGGHFLALLHGRKPSKIETDMMNVSLILY
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHEEEEEEEE
AEHEFNASTFAARVTAATLADFYSAITSAIGTLRGPLHGGANEAAMELIERFKTPDEAAI
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHH
GIKQMLASKELIMGFGHRVYTTCDPRSDIIKKWSFRLGEEKGNLLLYHISERIEEIMWQE
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHH
KKLFPNLDFYSASAYHYCDIPTHLFTPIFVMSRITGWSAHVFEQRANNKLIRPTSEYIGP
HHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHCCC
DSRPFPAIETRG
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]