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The map label for this gene is ndk [H]

Identifier: 54294409

GI number: 54294409

Start: 1647095

End: 1647520

Strand: Direct

Name: ndk [H]

Synonym: lpl1478

Alternate gene names: 54294409

Gene position: 1647095-1647520 (Clockwise)

Preceding gene: 54294408

Following gene: 54294410

Centisome position: 49.23

GC content: 39.44

Gene sequence:

>426_bases
ATGGCAAAAGAATTAACATTATCTATTATTAAACCTGATGCTGTAGCGAAGTCTGTGATAGGTGAAATATATACCCGCTT
TGAAAAAGCAGGCTTGGATATTGTTGCCGCTAAAATGACACAACTTTCACGCGAACAAGCTGAGAGCTTTTATGATATTC
ATCGCGCGCGACCATTCTTTAAGGATCTGGTGGATTTTATGATTTCTGGTCCTGTAATGATCCAAGTATTAAAAGGTGAA
AATGCTGTCGCTAAAAACAGAGAAATTATGGGCGCGACAAATCCCAAAGAAGCAGCACCTGGAACTATACGTGCTGATTT
TGCTGATAGTATTGATGCAAATGCTGTGCATGGTTCTGACAGCCTTGAAAATGCTGCTCGTGAAATAGCATTTTTCTTTG
AACCGCATGAGTTGTGCAATAGATAA

Upstream 100 bases:

>100_bases
ACTATTGACTGAATGGTTGAATGCATGAATTTTTATTAGCCAGACCACTATGAATTCATGTATAATAATGCACTTTAAAT
TAATCTCATTGGAGTGCATA

Downstream 100 bases:

>100_bases
AGGCAGGCTTGGGAGCGGTAATGGACCAACAAAAAGTGAATCTATTAAATTATAATTACTTACAGCTACGAGAATTATTG
ATGGCGTGGGATGAAAAGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDLVDFMISGPVMIQVLKGE
NAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEPHELCNR

Sequences:

>Translated_141_residues
MAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDLVDFMISGPVMIQVLKGE
NAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEPHELCNR
>Mature_140_residues
AKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDLVDFMISGPVMIQVLKGEN
AVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEPHELCNR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=46.7153284671533, Blast_Score=132, Evalue=8e-32,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=43.7956204379562, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=43.7956204379562, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=43.7956204379562, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=43.7956204379562, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=43.7956204379562, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.7956204379562, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.7956204379562, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=40.7142857142857, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=39.2857142857143, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=39.2857142857143, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=38.2352941176471, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI148839372, Length=136, Percent_Identity=36.7647058823529, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4505413, Length=133, Percent_Identity=36.8421052631579, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=58.8652482269503, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=42.3357664233577, Blast_Score=126, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45549037, Length=138, Percent_Identity=45.6521739130435, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=33.0827067669173, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15559; Mature: 15428

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFF
CCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KDLVDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSD
HHHHHHHHCCCCEEEEECCCCCHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCH
SLENAAREIAFFFEPHELCNR
HHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
AKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFF
CCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KDLVDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSD
HHHHHHHHCCCCEEEEECCCCCHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCH
SLENAAREIAFFFEPHELCNR
HHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA