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The map label for this gene is trxC [H]

Identifier: 54294298

GI number: 54294298

Start: 1519397

End: 1519759

Strand: Direct

Name: trxC [H]

Synonym: lpl1363

Alternate gene names: 54294298

Gene position: 1519397-1519759 (Clockwise)

Preceding gene: 54294297

Following gene: 54294300

Centisome position: 45.41

GC content: 38.02

Gene sequence:

>363_bases
ATGCCGACCCAGACTATTAAAAGCGCTGAATTTGAATCATTAATTAATGACAATGAGATAGTTTTCATTGATTTCTGGGC
TGGGTGGTGTGCTCCCTGTAAGCAATTTTCAAAAGTATATGAGCAAGTTTCCGATCAATTTCCAGCTATTAAATTTGTTA
AAGTTAACATTGAAGAGCAACAAGAGTTAGCAGATTTTTTCGAGATCCGATCCATCCCTCATCTTATGGTTTTCAAAGAC
AGTATTGTTATTTATTCTGATGCTGGAAGCATACCCGAGTCCACTTTAAAAGAATTGGCGCAGCAAGCACTTGATGCTGA
TGTTAGTGAAATACGAGCTCAGCTTGAGCAGAAGGATAAGTAG

Upstream 100 bases:

>100_bases
GTTCTAAAGAAGCTCCAAAATTTCACACTATTAGTGGTACAGGTACAGTAGATCAAATATTTGATAACATCGTAACGATA
CTCGAAACTTAGGAGTTAAC

Downstream 100 bases:

>100_bases
ATATACTAGCCAGATAATCAGCAAGTTCTTTTTTACTGGCATTATCCATAGTAAGGCCGAGCTTGGTTCGGCGGTTAAGT
ATGTCATCACAATAATTCGC

Product: hypothetical protein

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 120; Mature: 119

Protein sequence:

>120_residues
MPTQTIKSAEFESLINDNEIVFIDFWAGWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQQELADFFEIRSIPHLMVFKD
SIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK

Sequences:

>Translated_120_residues
MPTQTIKSAEFESLINDNEIVFIDFWAGWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQQELADFFEIRSIPHLMVFKD
SIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK
>Mature_119_residues
PTQTIKSAEFESLINDNEIVFIDFWAGWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQQELADFFEIRSIPHLMVFKDS
IVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=95, Percent_Identity=37.8947368421053, Blast_Score=82, Evalue=8e-18,
Organism=Escherichia coli, GI87082331, Length=90, Percent_Identity=32.2222222222222, Blast_Score=68, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=103, Percent_Identity=32.0388349514563, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=100, Percent_Identity=31, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=103, Percent_Identity=28.1553398058252, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13750; Mature: 13618

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTQTIKSAEFESLINDNEIVFIDFWAGWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQ
CCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHH
QELADFFEIRSIPHLMVFKDSIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK
HHHHHHHHHHCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PTQTIKSAEFESLINDNEIVFIDFWAGWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQ
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHH
QELADFFEIRSIPHLMVFKDSIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK
HHHHHHHHHHCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]