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The map label for this gene is glpK [H]

Identifier: 54294300

GI number: 54294300

Start: 1521301

End: 1522776

Strand: Direct

Name: glpK [H]

Synonym: lpl1365

Alternate gene names: 54294300

Gene position: 1521301-1522776 (Clockwise)

Preceding gene: 54294298

Following gene: 54294302

Centisome position: 45.47

GC content: 40.31

Gene sequence:

>1476_bases
ATGAACTATATACTAGCCATTGACCAGGGAACAAGTAGTACTCGCGCTATGATCTACACCCTTCAAGGCGATTTAATCGC
AAATAGTCAGTATCCTCTTACTCAATATTACCCCAATTCGGGTTGGGTAGAACACGATCCTGAGGAAATATGGCAAAAAA
CTCTGAATGCGATGAGGGATGTTGTATCTCAAGTTCAAGGAAAAGCAATTTTATGCTGTGGCCTTACCAACCAACGGGAA
ACTACTCTGATTTGGAACAAAAAAACAGGGGAATGCCTCGCGCCAGCTATTGTGTGGCAAGATAGACGTACGGAGGAGTT
TTGTTATTCCTTGTCTGAATACTCGTCAATGATACAAGAGAAAACCGGATTACTTCCTGATCCCTATTTTTCAGCGAGCA
AGTTAAACTGGTTACTAAAGAATAATGCTCAAGCTCAATCTCTAATTAACCAGGGGGATTTGGCATTTGGAACAATAGAC
AGTTTTTTAATATGGCGCATGACTAAAGGTGCAAGTCATGCTACCGATATCACCAACGCATCCAGAACTATGCTGTTTAA
TATCCATGATGAAAAATGGGATAAGCAGTTGCTGGAGCTTTTTTCTATTTCAGAATCGGTATTACCAGCGGTATTCTCCA
GTGATAATCATTTTGGGATGATAGATAAAGAATGGCTGGGAGTAGAAATACCAATTACCGGGGTTGCAGGTGATCAACAA
GCCGCTTTAATTGGGCAAGGTTGTTTTAATGGAGGAATGGTTAAAGCTACTTTTGGTACGGGGGGATTTTTATTACTTAA
TACAGGTGATAAACCAGTTTTCTCAAAGCATAAATTGTTGACTACTATTGCCTATAAAATTAAAGAAAAAACAGTATATG
GTTTGGAGGGTAGTATTTATCATGCCGGAACTACTGTTAAATGGTTACGCGATGAAATGAAGTTGATATCTCATTCTGCT
GAAACTGAAGTATTGGCTCGAAGTCTTGATAGCAATAACGGCGTATATCTTGTTTCATCTTTTACTGGCCTGGGAGCACC
TCATTGGTTATCAATAACAGGAACAGCTATTATAGGTGTATCCCGTTCGACGAATAGAGCACATTTTGCCAGAGCCGCCT
TGGAAGGAGTTTGTTATCAAACACGTGATGTATTAACCTGTATGAGAGATGATAGTCAATTGGATTTGACTTTATTAAGA
GCGGATGGAGGGATGGCAGTAAACCAATGGTTTCTACAATTTATGGCTGATCAGTGCCAGTTGACAATTCAAAAACCCAA
AGACATTGAAACGACTGCCAAAGGGGCAGCAGTATTAGCCGCAATAGGTTCTGGACTATTTGATTCAGTTTCTTCAGTAA
ATAAGGTATGGGACATTGAGAACGAGTTTCAGCCATTCAGGGAAAGAGAGGTAGTTGAAAAAGATTTTCGTGGCTGGCTA
GAGGCGTTGGCAATGGTTAAAGCAAGGCATGCATAG

Upstream 100 bases:

>100_bases
GCCTCCACCAATAATTGCAACATCAAAAACCTGATCCATGTTTTTATCTCCGAAAAAAGATTACACTCAATATATATAAA
TATAGAGGGATTTTATAATA

Downstream 100 bases:

>100_bases
GCTGGTCTTATATTTAAATTGGTGCAATTAAATTAGATTGCAGTAGCTCGTATTATAGTTTAATACAAGCTACTGATTAA
CACATTGGATTTTTTATTTT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPAVFSSDNHFGMIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDIENEFQPFREREVVEKDFRGWL
EALAMVKARHA

Sequences:

>Translated_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPAVFSSDNHFGMIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDIENEFQPFREREVVEKDFRGWL
EALAMVKARHA
>Mature_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPAVFSSDNHFGMIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDIENEFQPFREREVVEKDFRGWL
EALAMVKARHA

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=442, Percent_Identity=44.7963800904977, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI189409120, Length=442, Percent_Identity=44.7963800904977, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI42794763, Length=447, Percent_Identity=44.2953020134228, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI41393575, Length=442, Percent_Identity=44.5701357466063, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI88196792, Length=501, Percent_Identity=31.7365269461078, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=44.421906693712, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1789987, Length=486, Percent_Identity=24.4855967078189, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790005, Length=512, Percent_Identity=22.8515625, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789168, Length=493, Percent_Identity=24.1379310344828, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=447, Percent_Identity=38.7024608501119, Blast_Score=325, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71986140, Length=511, Percent_Identity=22.7005870841487, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71986147, Length=287, Percent_Identity=26.1324041811847, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=484, Percent_Identity=32.8512396694215, Blast_Score=256, Evalue=8e-69,
Organism=Drosophila melanogaster, GI17864214, Length=458, Percent_Identity=41.4847161572052, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24655555, Length=452, Percent_Identity=37.6106194690265, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24655560, Length=452, Percent_Identity=37.6106194690265, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24655570, Length=452, Percent_Identity=37.6106194690265, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24655574, Length=452, Percent_Identity=37.6106194690265, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24655565, Length=452, Percent_Identity=37.6106194690265, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24654573, Length=383, Percent_Identity=43.6031331592689, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI19922058, Length=526, Percent_Identity=28.8973384030418, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24652871, Length=493, Percent_Identity=29.0060851926978, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI21357867, Length=528, Percent_Identity=27.0833333333333, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24656367, Length=508, Percent_Identity=27.1653543307087, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24656372, Length=369, Percent_Identity=28.1842818428184, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45552909, Length=286, Percent_Identity=29.020979020979, Blast_Score=125, Evalue=9e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54594; Mature: 54594

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCCHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESVLPAVFSSDNHFGMIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCC
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIY
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCEEECCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDIENEFQPFREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHH
EALAMVKARHA
HHHHHHHHCCC
>Mature Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNSGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCCHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESVLPAVFSSDNHFGMIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCC
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTVYGLEGSIY
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCEEECCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLARSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDIENEFQPFREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHH
EALAMVKARHA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA