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The map label for this gene is licA [H]

Identifier: 54294294

GI number: 54294294

Start: 1515580

End: 1516731

Strand: Direct

Name: licA [H]

Synonym: lpl1359

Alternate gene names: 54294294

Gene position: 1515580-1516731 (Clockwise)

Preceding gene: 54294292

Following gene: 54294296

Centisome position: 45.3

GC content: 36.46

Gene sequence:

>1152_bases
ATGACGTTTATGAAATTATATTTTTTTGGTGATGATAATAATAAACCCAAATTAAGCGAACATTTAATCATTTACATACT
CAGTTTGCTAGATCCCAAGTCTCGGTCTGTTGCTTCTTTAGTGAATAAAGACTGGTCTCGGCTGGTTCAATTGACACGGC
AATACCTGTCTATGTTACCGGTAATTCATCGAATACCTTTATTTGCGAATTTGGGTCTTGACGTTTTGAAATTAAAATTA
ATGACAGGTGGTATGACGAATTCCACATTTAGGTTAAGAATCAAAAACGCACCTGAGAAATGGGTTATGCGGATTCCTGG
AATAGGCTCTTCAGCATTTATAACCAGAAGAGATGAAGCTCACAACGCTAGACAAGCCGAAAAACTTGGACTGAATGTTC
CAATAGCTTTCTTTGATCCAGAAGATGGACTGCAGGTAACACGCTTTATAGAAGGAGTACATTTTCTGGATGATAAAGCC
TTGGCCCGCAAGGAAATTCTGTATGAGGTAGCATCTATGATGAGAAGACTTCATAAATCTCCTCCCTTTGATAATAGCAC
GCTTTTTTTTGAGCGAAATGAAGAATTATTGGATTTATTAAAACGAAAATCCTTTAATTTTCCAGGGGAAATAGAATTTA
TTGAGCAACAAATGAAAAATCTAAAGGAGATTTTTTATTCTTATCATATTCAGCAATTTCCTTGCCACAATGATACAACG
CCACTTAATTTTATCTTGTCCGAAAATCCAGAAATCAAGGGTTCTGAAAAGATTCATCAGATTGATTGGGAATATTCAAG
TAATAATGATTTTATTTGGGATTTGGTTTATTTTATGGTTGAGGCCAAGCTAAACCGCGAACAACAGCTTATTCTGTTGA
AAGCTTACTTTAATACAGAAGAGCTGAGTGACTCTCTGTTGGCATGGATAGAGGTTTATAAACCCATCATTGAGTGGTGG
ATAACCATTTGGTCATGGACACAATTGGCAAATGGAGCTAATGCAGTTGATTTGAGTTCTTATGAGCAACTAGGGCTTGA
ACGGTATCATAACACCTTAAATCACTTGAAAAGTGAGGACTATGTCAAAGCCCTAGAACTGATTGAAGCAGATAGTCATA
GCCTTACTTTTACTGGGCAGAGACTTTTTTAG

Upstream 100 bases:

>100_bases
TGCAAAAACATTCAATATTCCCAGGAAAGTAATGATGAATTATATGTTATTTTATTATCAGTTTTTATATAATGCATTCC
GTTTTATCATTAATTAATAA

Downstream 100 bases:

>100_bases
CGGTCGCCATTATCTAGAGTAGACAACTCGTTTACAGTGACGATTAAGATCTTCAGATCATTTTTTTGAGAAATTCCTGT
AAATGCATCTTGTCTTTCTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSRSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKL
MTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNARQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHFLDDKA
LARKEILYEVASMMRRLHKSPPFDNSTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFYSYHIQQFPCHNDTT
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELSDSLLAWIEVYKPIIEWW
ITIWSWTQLANGANAVDLSSYEQLGLERYHNTLNHLKSEDYVKALELIEADSHSLTFTGQRLF

Sequences:

>Translated_383_residues
MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSRSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKL
MTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNARQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHFLDDKA
LARKEILYEVASMMRRLHKSPPFDNSTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFYSYHIQQFPCHNDTT
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELSDSLLAWIEVYKPIIEWW
ITIWSWTQLANGANAVDLSSYEQLGLERYHNTLNHLKSEDYVKALELIEADSHSLTFTGQRLF
>Mature_382_residues
TFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSRSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKLM
TGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNARQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHFLDDKAL
ARKEILYEVASMMRRLHKSPPFDNSTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFYSYHIQQFPCHNDTTP
LNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELSDSLLAWIEVYKPIIEWWI
TIWSWTQLANGANAVDLSSYEQLGLERYHNTLNHLKSEDYVKALELIEADSHSLTFTGQRLF

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 44910; Mature: 44779

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSRSVASLVNKDWSRLVQLTRQYLSMLP
CCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIHRIPLFANLGLDVLKLKLMTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEA
HHHHCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEECCCCCCCCEEEECHHH
HNARQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHFLDDKALARKEILYEVASMMRRLHKS
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
PPFDNSTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFYSYHIQQFPCHNDTT
CCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTE
CEEEEECCCCCCCCCCCEEEEECEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHH
ELSDSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGLERYHNTLNHLKSED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
YVKALELIEADSHSLTFTGQRLF
HHHHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure 
TFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSRSVASLVNKDWSRLVQLTRQYLSMLP
CEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIHRIPLFANLGLDVLKLKLMTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEA
HHHHCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEECCCCCCCCEEEECHHH
HNARQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHFLDDKALARKEILYEVASMMRRLHKS
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
PPFDNSTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFYSYHIQQFPCHNDTT
CCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTE
CEEEEECCCCCCCCCCCEEEEECEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHH
ELSDSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGLERYHNTLNHLKSED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
YVKALELIEADSHSLTFTGQRLF
HHHHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]