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The map label for this gene is tmk [H]

Identifier: 54294285

GI number: 54294285

Start: 1505905

End: 1506543

Strand: Direct

Name: tmk [H]

Synonym: lpl1350

Alternate gene names: 54294285

Gene position: 1505905-1506543 (Clockwise)

Preceding gene: 54294284

Following gene: 54294286

Centisome position: 45.01

GC content: 37.09

Gene sequence:

>639_bases
ATGTCATCGTTAACCGGGAAATTGATAGTTATTGAAGGTTTAGAGGGAGCAGGAAAATCTACAGCTGTCAATTTAGTTGT
TGAACTGTTATCCCAAAAAAAAATCAGTACTATAACCACGAGAGAACCCGGAGGAACAAAAATAGGTGAAATTTTAAGAA
GTATTATTAAAAATCCAGAGTACAATAATGTTCTGGATGACAGAAGCGAATTACTTCTCCTGTATGCCGCAAGAATACAA
CTGATTGAGCAAGTGATCAAACCCGCTTTAAATGTGGGGCAGTGGGTCATAGCTGATCGATTTGAACTTTCCACTTTAGC
TTATCAGGGAGGGGGCCGCAAAATGGATATGCGGGTTATTAATGAGCTATCGAATTTCTGTTTAAAAGGATTCAAACCTG
ATCTCACTTTATATTTGGACATTAATCCCGAGCTTGGCATGATAAGAGCCAAATCAAGGGGAAAATTTGACAGGATTGAG
CAGGAATCAATTGAGTTTTTTCATAGAATACATGATACATATCATATTCTTGTTAAACAAAACCCGGAAATTATGATGAT
TGATGCTAACAGGTCTTTGGAAGAGGTTCAATCTTCCATTCAATCAGTAATCGAGGAGTTTATAGAGCATAACCTATGA

Upstream 100 bases:

>100_bases
ATTTATACTTTGTTGCCAAAGGAGATGGCACTCATCAATTCTCCGAAACTTATGAGCAACAAAGAAAAGCAATTAACCAA
TATAGACGCAAGGATTATTA

Downstream 100 bases:

>100_bases
TTACTTATCAAGAACAATGGCAGAAAATGCAAATGGCCTTGGCGATAAGACGAATTCCTCAAGCCATGCTATTTTTGGGT
TCTTTGCATTGTGGTCTTAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHILVKQNPEIMMIDANRSLEEVQSSIQSVIEEFIEHNL

Sequences:

>Translated_212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHILVKQNPEIMMIDANRSLEEVQSSIQSVIEEFIEHNL
>Mature_211_residues
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQL
IEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQ
ESIEFFHRIHDTYHILVKQNPEIMMIDANRSLEEVQSSIQSVIEEFIEHNL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI42544174, Length=214, Percent_Identity=30.3738317757009, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=50.9708737864078, Blast_Score=211, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6322517, Length=218, Percent_Identity=27.5229357798165, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573735, Length=207, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24028; Mature: 23897

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPE
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCHHHHHHEECCCCCCHHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHILVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
NPEIMMIDANRSLEEVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCHHHHHHEECCCCCCHHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHILVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
NPEIMMIDANRSLEEVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA