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The map label for this gene is fadD [C]

Identifier: 54293926

GI number: 54293926

Start: 1102577

End: 1104244

Strand: Direct

Name: fadD [C]

Synonym: lpl0982

Alternate gene names: 54293926

Gene position: 1102577-1104244 (Clockwise)

Preceding gene: 54293925

Following gene: 54293931

Centisome position: 32.96

GC content: 38.55

Gene sequence:

>1668_bases
ATGCAAAAAGAATCCAATTCCAATTCATTATTTGACTTACTGTTGAAAAATGAAAGAAATGCGGCAGATCGAGTGTATTT
AAGACAACCAAAAAATGGAGTTTGGCATGAATACACCTGGTCGTCAGTGATGCTGCAGGCCCGAAAAGTAGCTGGTTTTT
TACACCATCTGGGGTTAAAAAAAGGCGACCACATTTCCATTATCTCCAAGAATTGTGCGGAATGGTTTATCACAGATTTT
GGAATTCATATTGCTGGCATGGTCAATGTTCCATTATTTGCCAATCAAAATGAGGAAAGTGCGCATTATGTTTTAGAGCA
TGGGGATGTGAAACTGGTTTTTGTTGGAAAATTAGATGATCATCAGCGAGTCAGGCAATTTATCCCTAAGAGTTATCCTA
CAATTGGTTTTGATTACCATAAAGATTTGCAAGTTGATTACGAATGGTCTGATGTTTTGAAAAGTGACCCTATGATTAAC
CTGGTGGAGCCAGAGCCAGATGCGTTGTATACCATTATTTATTCATCCGGGACTTCGGGGGCACCCAAAGGAGCTATGTA
TACCAATCGGTCCATAGCCAATTACTTGACAGTTTTCCCCAAAGACTTGCTCAGAATCAGAGAGTTGGAACATTATAAAT
TAATATCTTATCTTCCCCTGGCCCATGTCTATGAGCGATCTGCCATCCAATTAGGCAGTGTTGCTATTAATGCATCGGTA
TCTTTTGTTGAAAGTCTGGAGAAGTTTGCAGAGAATTTAAGGGAAGTTAGTCCCACCTTTTTCACTGCAGTTCCACGCAT
TTGGGGAGTATTTAAGCAAAAAATTGAACAAAAACTGCCGCCAGCCAAATTGAATTTTTTATTAAAAATTCCCCTTATAT
CCAGTTTGATAAAAAGAAAGATCATTCACAGTTTAGGATTAAGCGAGTGTACTAATTGTTTTAGCGGAGCATCTCATCTG
CCAATATCCATTATTGATTTTTTTGAAAAACTGGGAATATATATTCAGGAAGGATATGGTCAATCCGAGAATTTGGCTTA
TGCTACCTTATCGATGTTAAATGAGAGAAAACGTGGTTACGTTGGTACCCCGAGGCTGGAGGTTGAGATAAAAGTAGGCG
AAGAGAATGAATTGCTAATGAAGTGCCCTTGTCTAATGTCAGGTTATTACAAAAATGAACAAGCAACTAAAAATGCCTTT
ACAGAAGAGGGTTGGTTGCGAACAGGAGATGTTGTTGATGTTGATAATGAAGACAGAGTTAAAATATTAGGAAGACTTTC
TGAGAACTTTAAAAACCAGACAGGAGAGTTCATTGCTCCTTCGCCAATAGAAAAACTGTTTTCAGTGAACCCTATGTTAG
AACAACTGTGCCTGGTAGGTAGAGAGTTACCCAATAACGTTTTGTTAGTTACCTTGAATGAAGCGGTGCGTTTGGGTATG
CCAAAAGAGGAGATCACTCACTCATTGCAAGAAACCTTAAAGCAAGTCAATTCCAAATTGGTTAAATACGAAAAAGTCAG
TCACATCCTTGTGCTGAAAGATGCCTGGACAACTGAAAATGATAAATTAACACCTACACTGAAAGTAAAGAGAAGGGTAG
TTGAAAAAGATTATGCCGAGTTAATCCAAAAGGCACTGCAGCAATCTCAGTCAATCGTTTGGGAATGA

Upstream 100 bases:

>100_bases
AGGCGATTCATGAAGGTGAAAATTGTGTTTTGCGAGAAAAAAATAATATTTTACAACTAGTTGGTCTAAAATAGTAATTA
AACAAGCTTAAGGAAGAGCC

Downstream 100 bases:

>100_bases
GGAGACAGTTTATTTAATAAAGAACTGATTTCAAATATTCGTTCCTCTGCTGACGTGCTGTCTAAAGTAAAGCGCAGACG
TTGCGGTCCTTCCATTTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MQKESNSNSLFDLLLKNERNAADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFITDF
GIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEAVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE

Sequences:

>Translated_555_residues
MQKESNSNSLFDLLLKNERNAADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFITDF
GIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEAVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE
>Mature_555_residues
MQKESNSNSLFDLLLKNERNAADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFITDF
GIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEAVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794756, Length=594, Percent_Identity=27.1043771043771, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI42794760, Length=594, Percent_Identity=27.1043771043771, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI42794758, Length=594, Percent_Identity=27.1043771043771, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI83745141, Length=594, Percent_Identity=25.7575757575758, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI40807491, Length=531, Percent_Identity=25.9887005649718, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI57165412, Length=576, Percent_Identity=27.0833333333333, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI57165410, Length=580, Percent_Identity=26.7241379310345, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI27477105, Length=610, Percent_Identity=22.4590163934426, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI42794754, Length=597, Percent_Identity=23.9530988274707, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI42794752, Length=597, Percent_Identity=23.9530988274707, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI12669909, Length=617, Percent_Identity=22.5283630470016, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI4758332, Length=617, Percent_Identity=22.5283630470016, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI156151445, Length=475, Percent_Identity=22.3157894736842, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1788107, Length=524, Percent_Identity=22.5190839694656, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17556552, Length=615, Percent_Identity=26.0162601626016, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17510401, Length=583, Percent_Identity=27.2727272727273, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17541856, Length=588, Percent_Identity=25.8503401360544, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193204819, Length=621, Percent_Identity=26.8921095008052, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17564090, Length=558, Percent_Identity=22.0430107526882, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25147511, Length=581, Percent_Identity=22.8915662650602, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17553312, Length=622, Percent_Identity=23.3118971061093, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=564, Percent_Identity=23.758865248227, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=564, Percent_Identity=23.758865248227, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=564, Percent_Identity=23.758865248227, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133901848, Length=244, Percent_Identity=29.0983606557377, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=371, Percent_Identity=25.8760107816712, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=469, Percent_Identity=25.5863539445629, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=516, Percent_Identity=22.093023255814, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=464, Percent_Identity=25, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320852, Length=571, Percent_Identity=24.8686514886165, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323903, Length=435, Percent_Identity=27.1264367816092, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6322182, Length=434, Percent_Identity=26.4976958525346, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324893, Length=451, Percent_Identity=24.8337028824834, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17933690, Length=620, Percent_Identity=23.8709677419355, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281366413, Length=569, Percent_Identity=25.3075571177504, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24666501, Length=561, Percent_Identity=25.3119429590018, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24666497, Length=561, Percent_Identity=25.3119429590018, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI62471681, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471687, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24586634, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22026970, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471689, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471679, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471683, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471685, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24586636, Length=596, Percent_Identity=23.8255033557047, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19921316, Length=623, Percent_Identity=22.1508828250401, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355181, Length=495, Percent_Identity=24.4444444444444, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 63298; Mature: 63298

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKESNSNSLFDLLLKNERNAADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLK
CCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
KGDHISIISKNCAEWFITDFGIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDD
CCCEEEEEHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEAVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHCCC
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQQSQSIVWE
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MQKESNSNSLFDLLLKNERNAADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLK
CCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
KGDHISIISKNCAEWFITDFGIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDD
CCCEEEEEHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPNNVLLVTLNEAVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHCCC
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQQSQSIVWE
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]