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The map label for this gene is gpi [H]

Identifier: 54293743

GI number: 54293743

Start: 902341

End: 903840

Strand: Direct

Name: gpi [H]

Synonym: lpl0796

Alternate gene names: 54293743

Gene position: 902341-903840 (Clockwise)

Preceding gene: 54293742

Following gene: 54293744

Centisome position: 26.97

GC content: 35.8

Gene sequence:

>1500_bases
ATGATCAGAAATAGCATGAAGTCTCACACAGAATTATTATCATGGAGTTTGCTTCAAAAAGAAGCAAAAAGAGTGCGTTT
AAATTCAGATTCTCAACCACGCGTTGTTCCGGATTCCAACAATTATGAATCGAGAAAACAGATCAATTGTATTGTGTACG
ACTATTCCAGGCAGAGAGTAAACAGAACCATCATTGATTTGCTTATCGATTTGGCTAATGAAGTCAAATTACCAGAAAAA
ATTGATAATTTAATCAATGGTAAAAAAATCAATATCAGCGAAAACAGGCCTGCATTACATACTGCACTGCGAGATTTAAG
CAATAAATCAATCTTGATTGATGGGCTGGATATCATGTCTGAAGTGGTAAGTACCCGAGAAAAAATCAGAATGATATCTA
ACCGAATCAGGGAAAAGAAGTGGCTGGGTTATTCAGGGTTACCAATAACTGATGTTGTAAATATAGGCATTGGCGGCTCG
GATTTAGGTCCTCGTGTATGCATCCATGCTTTATCTAATTATGTTTCCAAAGAATTTAATTATCATTTTATCTCAGATGT
TGATCCGGCCAGTTTTAACGATGTTATTGTAAAAATTAATCCAGAAACCACCTTGTTTATTGTTTCTTCCAAATCATTTA
CTACAAAAGAAACTCTATTAAATGCCAGAAAAGCTTTTGCACTGTATGAGGATAGGGCCTCTATCGATCAACATTTTATA
GCTGTAACCGCACATCCGGAAAGAGCCCATCAAATAGGTATTAAAACAGTGTTACCGATTTGGGATTGGGTTGGTGGTCG
ATTTTCTTTTTGTTCCGCAGTTAATTTAATTACTGCCATTGCAATTGGTTATGAACAATTTGTTGAATTGCTGGCTGGTG
CCCATGATGTTGATACTCATGTTCAGTTTACTGATTTTAAAAATAATATTCCTGTGCTAATGGCTTTAATCGGTATATGG
AATAACAATTTTTTGAATATTCATAATTTACTTATTCTTACCTATTCAAAAAAACTGGAGTACTTTGTTCCTTATGTACA
ACAGCTGGATATGGAGAGTAATGGGAAGTCCATTGATGTGAATGGAAGAATGGTAGGTTACGCCACTGGACCTATCGTTT
GGGGTGGATTAGGAAATCAGGCACAGCATAGCTATTTTCAATTATTATGTCAGGGTACGCATCGATGTGTTGGCGATTTT
ATTACTTTGAAAACTAATGATGAGCATGAGATTAATTCCATGTGTCATTATAAAATGAAAGTTTTAAGTGAGGGAATTCA
AACAATTGAAAATCCCTATGGGTATATTCCTGGCAATATGCCAATGAATCATCTCATTTTGTCAGATTGTTCTCCTTATA
CATTAGGGGCACTGGTGGCACTCTATGAGCATAAAATTTTTGTACAAAGTGTGATATGGAATATTAACCCATTCGATCAG
CCCGGTATTGAAAGCGCCAAGAGTGCTCACAGAGAAATCACATTGTCAAGCGAATTATAA

Upstream 100 bases:

>100_bases
ATAAACTATCAAATACAGTTCAGTATTACTTAACACGATATGAGCACGAAATTAATGTTTAATAAATTGAAAATAATCAG
GTAACATAGCCTTTATTTTA

Downstream 100 bases:

>100_bases
AGGGGTGATCAATGCTATAAATTAGTTTATTTGTTAAACTAAACTTTATATTTTATTGACATTATCAACGTATTTTAATG
TATTACTGCAATAAACTTGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MIRNSMKSHTELLSWSLLQKEAKRVRLNSDSQPRVVPDSNNYESRKQINCIVYDYSRQRVNRTIIDLLIDLANEVKLPEK
IDNLINGKKINISENRPALHTALRDLSNKSILIDGLDIMSEVVSTREKIRMISNRIREKKWLGYSGLPITDVVNIGIGGS
DLGPRVCIHALSNYVSKEFNYHFISDVDPASFNDVIVKINPETTLFIVSSKSFTTKETLLNARKAFALYEDRASIDQHFI
AVTAHPERAHQIGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIW
NNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMVGYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDF
ITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
PGIESAKSAHREITLSSEL

Sequences:

>Translated_499_residues
MIRNSMKSHTELLSWSLLQKEAKRVRLNSDSQPRVVPDSNNYESRKQINCIVYDYSRQRVNRTIIDLLIDLANEVKLPEK
IDNLINGKKINISENRPALHTALRDLSNKSILIDGLDIMSEVVSTREKIRMISNRIREKKWLGYSGLPITDVVNIGIGGS
DLGPRVCIHALSNYVSKEFNYHFISDVDPASFNDVIVKINPETTLFIVSSKSFTTKETLLNARKAFALYEDRASIDQHFI
AVTAHPERAHQIGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIW
NNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMVGYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDF
ITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
PGIESAKSAHREITLSSEL
>Mature_499_residues
MIRNSMKSHTELLSWSLLQKEAKRVRLNSDSQPRVVPDSNNYESRKQINCIVYDYSRQRVNRTIIDLLIDLANEVKLPEK
IDNLINGKKINISENRPALHTALRDLSNKSILIDGLDIMSEVVSTREKIRMISNRIREKKWLGYSGLPITDVVNIGIGGS
DLGPRVCIHALSNYVSKEFNYHFISDVDPASFNDVIVKINPETTLFIVSSKSFTTKETLLNARKAFALYEDRASIDQHFI
AVTAHPERAHQIGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIW
NNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMVGYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDF
ITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
PGIESAKSAHREITLSSEL

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=476, Percent_Identity=39.0756302521008, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI296080693, Length=476, Percent_Identity=35.0840336134454, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1790457, Length=514, Percent_Identity=40.272373540856, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71996708, Length=475, Percent_Identity=38.7368421052632, Blast_Score=341, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI71996703, Length=475, Percent_Identity=38.7368421052632, Blast_Score=341, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6319673, Length=519, Percent_Identity=37.1868978805395, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24651916, Length=476, Percent_Identity=40.1260504201681, Blast_Score=357, Evalue=8e-99,
Organism=Drosophila melanogaster, GI24651914, Length=476, Percent_Identity=40.1260504201681, Blast_Score=357, Evalue=8e-99,
Organism=Drosophila melanogaster, GI17737445, Length=476, Percent_Identity=40.1260504201681, Blast_Score=357, Evalue=8e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 56426; Mature: 56426

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNSMKSHTELLSWSLLQKEAKRVRLNSDSQPRVVPDSNNYESRKQINCIVYDYSRQRV
CCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
NRTIIDLLIDLANEVKLPEKIDNLINGKKINISENRPALHTALRDLSNKSILIDGLDIMS
HHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHH
EVVSTREKIRMISNRIREKKWLGYSGLPITDVVNIGIGGSDLGPRVCIHALSNYVSKEFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCC
YHFISDVDPASFNDVIVKINPETTLFIVSSKSFTTKETLLNARKAFALYEDRASIDQHFI
EEEECCCCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
AVTAHPERAHQIGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTH
EEEECCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
VQFTDFKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDV
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEE
NGRMVGYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKMK
CCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
VLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
HHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGIESAKSAHREITLSSEL
CCCHHHHHHHHEEEECCCC
>Mature Secondary Structure
MIRNSMKSHTELLSWSLLQKEAKRVRLNSDSQPRVVPDSNNYESRKQINCIVYDYSRQRV
CCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
NRTIIDLLIDLANEVKLPEKIDNLINGKKINISENRPALHTALRDLSNKSILIDGLDIMS
HHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHH
EVVSTREKIRMISNRIREKKWLGYSGLPITDVVNIGIGGSDLGPRVCIHALSNYVSKEFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCC
YHFISDVDPASFNDVIVKINPETTLFIVSSKSFTTKETLLNARKAFALYEDRASIDQHFI
EEEECCCCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
AVTAHPERAHQIGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTH
EEEECCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
VQFTDFKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDV
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEE
NGRMVGYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKMK
CCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
VLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
HHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGIESAKSAHREITLSSEL
CCCHHHHHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA