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The map label for this gene is rmlA [H]

Identifier: 54293744

GI number: 54293744

Start: 903995

End: 904870

Strand: Direct

Name: rmlA [H]

Synonym: lpl0797

Alternate gene names: 54293744

Gene position: 903995-904870 (Clockwise)

Preceding gene: 54293743

Following gene: 54293745

Centisome position: 27.02

GC content: 37.9

Gene sequence:

>876_bases
ATGAAAGGTATTATCCTGGCAGGTGGTTTTGGTACAAGACTGTATCCTCTGACAAAATCCATTAGTAAGCATATGATCCC
GGTTTATGATAAACCAATGATTTATTATGCCATCTCTACATTAATGTTGGCTAATATCAGGGAAATACTGATTATTTCAA
CGGAGGAGCATCTTCCGCTGTATCAAAATTTATTGAGTGATGGTTCTCAGTGGGGCATCTCATTTGCCTATCTTGTGCAA
AATGAACCAAGGGGAATCGCGGAAGCATTCATTTTAGGTGAAAAATTTATTGGTAATGATTCTGTTTGCCTGGTTTTGGG
GGATAATATCCACCAGGGCAGAGGTTTTTCTGAATTATTACAAAATGCAAAATCAAAATTAAACGGTGCAACAGTATTTG
CCTATTATGTCGATAAACCCCAAGCCTATGGTGTAGTGGAGTTCAATGAAAAACAACAAGTCCTATCCATAGTGGAAAAA
CCAGCACAGCCCAAATCCAACTACGCAGTAACCGGATTATATTTTTATGATAATCAGGTTATAGAAATTGCCAAGAGTTT
AAAACCCTCAGGAAGGGGGGAGCTGGAAATAACTGACATCAATCAGTTTTATTTATATGAAAACAAACTGGATGTTCAGA
TTTTGGGAAGAGGTTTTGTCTGGCTGGATATGGGTACACCAGAAACCCTGTTATCAGCAAGTAACTATATCTGTACTATC
GAACAGCGGCAAGGTTTAAAAATTGGATGCCCTGAAGAAATCGCGTGGCGTATGAAGTTTATTAGTGATGATGAGTTACT
GTGCAGGGCTAGAGAACTTAATAAAAGTAGTTACGGTCAATATCTTGCAGAACTGCTTAATCATAAACGATATTAA

Upstream 100 bases:

>100_bases
ATTGACATTATCAACGTATTTTAATGTATTACTGCAATAAACTTGATAATATTTAAGGCTGTTATTTGTTCAAAGAAAAA
TAGAGAGTAGGCTCGATATA

Downstream 100 bases:

>100_bases
TTTTTTCAGGTTATAAAGTAGTGGCAAAAATATTAATTACCGGCGCGACAGGATTTATAGGACGAAGTTTAGTACCTGCT
TTGCTTTCTGAAGGACATGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGFGTRLYPLTKSISKHMIPVYDKPMIYYAISTLMLANIREILIISTEEHLPLYQNLLSDGSQWGISFAYLVQ
NEPRGIAEAFILGEKFIGNDSVCLVLGDNIHQGRGFSELLQNAKSKLNGATVFAYYVDKPQAYGVVEFNEKQQVLSIVEK
PAQPKSNYAVTGLYFYDNQVIEIAKSLKPSGRGELEITDINQFYLYENKLDVQILGRGFVWLDMGTPETLLSASNYICTI
EQRQGLKIGCPEEIAWRMKFISDDELLCRARELNKSSYGQYLAELLNHKRY

Sequences:

>Translated_291_residues
MKGIILAGGFGTRLYPLTKSISKHMIPVYDKPMIYYAISTLMLANIREILIISTEEHLPLYQNLLSDGSQWGISFAYLVQ
NEPRGIAEAFILGEKFIGNDSVCLVLGDNIHQGRGFSELLQNAKSKLNGATVFAYYVDKPQAYGVVEFNEKQQVLSIVEK
PAQPKSNYAVTGLYFYDNQVIEIAKSLKPSGRGELEITDINQFYLYENKLDVQILGRGFVWLDMGTPETLLSASNYICTI
EQRQGLKIGCPEEIAWRMKFISDDELLCRARELNKSSYGQYLAELLNHKRY
>Mature_291_residues
MKGIILAGGFGTRLYPLTKSISKHMIPVYDKPMIYYAISTLMLANIREILIISTEEHLPLYQNLLSDGSQWGISFAYLVQ
NEPRGIAEAFILGEKFIGNDSVCLVLGDNIHQGRGFSELLQNAKSKLNGATVFAYYVDKPQAYGVVEFNEKQQVLSIVEK
PAQPKSNYAVTGLYFYDNQVIEIAKSLKPSGRGELEITDINQFYLYENKLDVQILGRGFVWLDMGTPETLLSASNYICTI
EQRQGLKIGCPEEIAWRMKFISDDELLCRARELNKSSYGQYLAELLNHKRY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=247, Percent_Identity=24.2914979757085, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI11761621, Length=247, Percent_Identity=24.2914979757085, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=59.5070422535211, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790224, Length=289, Percent_Identity=56.401384083045, Blast_Score=340, Evalue=5e-95,
Organism=Escherichia coli, GI1788355, Length=243, Percent_Identity=23.0452674897119, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787488, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=256, Percent_Identity=25, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=254, Percent_Identity=29.1338582677165, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=25.7028112449799, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=25.7028112449799, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32949; Mature: 32949

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGFGTRLYPLTKSISKHMIPVYDKPMIYYAISTLMLANIREILIISTEEHLPL
CCCEEEECCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHH
YQNLLSDGSQWGISFAYLVQNEPRGIAEAFILGEKFIGNDSVCLVLGDNIHQGRGFSELL
HHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
QNAKSKLNGATVFAYYVDKPQAYGVVEFNEKQQVLSIVEKPAQPKSNYAVTGLYFYDNQV
HHHHHHCCCEEEEEEEECCCCEEEEEEECCHHHHHHHHHCCCCCCCCEEEEEEEEECCHH
IEIAKSLKPSGRGELEITDINQFYLYENKLDVQILGRGFVWLDMGTPETLLSASNYICTI
HHHHHHCCCCCCCCEEEEECEEEEEEECCEEEEEEECCEEEEECCCCHHHHCCCCCEEEE
EQRQGLKIGCPEEIAWRMKFISDDELLCRARELNKSSYGQYLAELLNHKRY
ECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGIILAGGFGTRLYPLTKSISKHMIPVYDKPMIYYAISTLMLANIREILIISTEEHLPL
CCCEEEECCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHH
YQNLLSDGSQWGISFAYLVQNEPRGIAEAFILGEKFIGNDSVCLVLGDNIHQGRGFSELL
HHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
QNAKSKLNGATVFAYYVDKPQAYGVVEFNEKQQVLSIVEKPAQPKSNYAVTGLYFYDNQV
HHHHHHCCCEEEEEEEECCCCEEEEEEECCHHHHHHHHHCCCCCCCCEEEEEEEEECCHH
IEIAKSLKPSGRGELEITDINQFYLYENKLDVQILGRGFVWLDMGTPETLLSASNYICTI
HHHHHHCCCCCCCCEEEEECEEEEEEECCEEEEEEECCEEEEECCCCHHHHCCCCCEEEE
EQRQGLKIGCPEEIAWRMKFISDDELLCRARELNKSSYGQYLAELLNHKRY
ECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]