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The map label for this gene is rmlB [H]

Identifier: 54293742

GI number: 54293742

Start: 901223

End: 902302

Strand: Direct

Name: rmlB [H]

Synonym: lpl0795

Alternate gene names: 54293742

Gene position: 901223-902302 (Clockwise)

Preceding gene: 54293741

Following gene: 54293743

Centisome position: 26.94

GC content: 34.35

Gene sequence:

>1080_bases
ATGATTTGCCAGATGTTATCGACCATTTTACAAAAAAGTAAGAATCACACTATGAAAAATCAGATGAACAACCTTTTGGT
AACTGGAGCTGCGGGTTTTATAGGAAGTAATTTTGTTAAATTTATGAACGATAAATACCCGGAGATCAAAATAATCAGTT
TGGATAAATTAACCTATGCAGGAAATAAAGCTAATTTGAGTGAAATGGCAGAATGTAAAAATCACCTTTTTGTACAAGGA
AACATATTGGACAAAAGTCTGGTCTTATCCTTACTAAGGGAATATGAAATAGATACGCTTGTCCATTTTGCAGCCGAATC
CCATGTGGATAATTCCATTGATAATCCGCAAATATTTCTTGAAACCAATGTAATTGGAACTTTTACTCTGTTAGAGGCGG
CAAGGATTTATTGGTTGAATGAAAGGCAATGGGATAAATCAAAGTGTCGGTTTCATCATGTATCAACCGATGAAGTGTAT
GGTTCATTAGAAAGAGAAGAGCCGGCGTTCACTGAAAAAAATTCTTATCAACCCAATTCCCCTTATTCAGCGTCCAAGGC
AAGTTCTGATCATATAGTCAGAGCTTATTATCATACCTATGGATTACCTGTTACCACTTCGAATTGTTCGAATAATTACG
GACCTAATCAACATAAAGAGAAGTTGATTCCTAAGGTAGTATACGCTTGTGTCAATCAGCTACCCATCACCGTTTATGGC
AACGGATCAAATATTCGCGATTGGTTGTATGTCATGGATCATTGCGAAGCAATTGATACCATTATTCAAAAAGGTGTATT
AGGGGAAGTTTATAATATAGGTGGTAATAACGAACTGGATAATTTAAGTTTGATAAAAATGATTTGTCAGATGATGGATG
ATTTAAAACCTATGGAAAAACCATATCATTCATTGATTACTTTTGTTGAAGATAGAAAAGGTCATGACAAACGATACGCT
ATAGACAATAGTAAAATTCAAAAGGAATTGGGTTGGGTTCCACAAGGTGATTTTGTTCATAAACTATCAAATACAGTTCA
GTATTACTTAACACGATATGAGCACGAAATTAATGTTTAA

Upstream 100 bases:

>100_bases
TCCGAAGAATATCCTACTAGGGCAACAAGGCCTAAAAATTCGGTACTTGATACAACAAAGATAGAAACAATATTGGGTAT
AAAAAGCTGTAGTTGGAAAA

Downstream 100 bases:

>100_bases
TAAATTGAAAATAATCAGGTAACATAGCCTTTATTTTAATGATCAGAAATAGCATGAAGTCTCACACAGAATTATTATCA
TGGAGTTTGCTTCAAAAAGA

Product: dTDP-D-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MICQMLSTILQKSKNHTMKNQMNNLLVTGAAGFIGSNFVKFMNDKYPEIKIISLDKLTYAGNKANLSEMAECKNHLFVQG
NILDKSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFLETNVIGTFTLLEAARIYWLNERQWDKSKCRFHHVSTDEVY
GSLEREEPAFTEKNSYQPNSPYSASKASSDHIVRAYYHTYGLPVTTSNCSNNYGPNQHKEKLIPKVVYACVNQLPITVYG
NGSNIRDWLYVMDHCEAIDTIIQKGVLGEVYNIGGNNELDNLSLIKMICQMMDDLKPMEKPYHSLITFVEDRKGHDKRYA
IDNSKIQKELGWVPQGDFVHKLSNTVQYYLTRYEHEINV

Sequences:

>Translated_359_residues
MICQMLSTILQKSKNHTMKNQMNNLLVTGAAGFIGSNFVKFMNDKYPEIKIISLDKLTYAGNKANLSEMAECKNHLFVQG
NILDKSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFLETNVIGTFTLLEAARIYWLNERQWDKSKCRFHHVSTDEVY
GSLEREEPAFTEKNSYQPNSPYSASKASSDHIVRAYYHTYGLPVTTSNCSNNYGPNQHKEKLIPKVVYACVNQLPITVYG
NGSNIRDWLYVMDHCEAIDTIIQKGVLGEVYNIGGNNELDNLSLIKMICQMMDDLKPMEKPYHSLITFVEDRKGHDKRYA
IDNSKIQKELGWVPQGDFVHKLSNTVQYYLTRYEHEINV
>Mature_359_residues
MICQMLSTILQKSKNHTMKNQMNNLLVTGAAGFIGSNFVKFMNDKYPEIKIISLDKLTYAGNKANLSEMAECKNHLFVQG
NILDKSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFLETNVIGTFTLLEAARIYWLNERQWDKSKCRFHHVSTDEVY
GSLEREEPAFTEKNSYQPNSPYSASKASSDHIVRAYYHTYGLPVTTSNCSNNYGPNQHKEKLIPKVVYACVNQLPITVYG
NGSNIRDWLYVMDHCEAIDTIIQKGVLGEVYNIGGNNELDNLSLIKMICQMMDDLKPMEKPYHSLITFVEDRKGHDKRYA
IDNSKIQKELGWVPQGDFVHKLSNTVQYYLTRYEHEINV

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=36.3095238095238, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI42516563, Length=340, Percent_Identity=24.4117647058824, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4504031, Length=261, Percent_Identity=24.5210727969349, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI48994969, Length=335, Percent_Identity=50.4477611940299, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1788353, Length=335, Percent_Identity=47.7611940298507, Blast_Score=337, Evalue=5e-94,
Organism=Escherichia coli, GI1786974, Length=341, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788366, Length=247, Percent_Identity=28.3400809716599, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=328, Percent_Identity=37.1951219512195, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI115532424, Length=338, Percent_Identity=32.8402366863905, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=25.0755287009063, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17539422, Length=188, Percent_Identity=30.3191489361702, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539424, Length=188, Percent_Identity=30.3191489361702, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901786, Length=188, Percent_Identity=30.3191489361702, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901788, Length=188, Percent_Identity=30.3191489361702, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901790, Length=188, Percent_Identity=30.3191489361702, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=189, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19923002, Length=345, Percent_Identity=27.8260869565217, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=22.9607250755287, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24158427, Length=249, Percent_Identity=24.8995983935743, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 41168; Mature: 41168

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICQMLSTILQKSKNHTMKNQMNNLLVTGAAGFIGSNFVKFMNDKYPEIKIISLDKLTYA
CHHHHHHHHHHHHCCCHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECEEEC
GNKANLSEMAECKNHLFVQGNILDKSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFL
CCCCCHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
ETNVIGTFTLLEAARIYWLNERQWDKSKCRFHHVSTDEVYGSLEREEPAFTEKNSYQPNS
EECCHHHHHHHHHHHHEEECCCCCCCHHCEEECCCHHHHHCCCCCCCCCCCCCCCCCCCC
PYSASKASSDHIVRAYYHTYGLPVTTSNCSNNYGPNQHKEKLIPKVVYACVNQLPITVYG
CCCCCCCCCCCEEEEEHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
NGSNIRDWLYVMDHCEAIDTIIQKGVLGEVYNIGGNNELDNLSLIKMICQMMDDLKPMEK
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHCCHHHH
PYHSLITFVEDRKGHDKRYAIDNSKIQKELGWVPQGDFVHKLSNTVQYYLTRYEHEINV
HHHHHHHHHHHCCCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MICQMLSTILQKSKNHTMKNQMNNLLVTGAAGFIGSNFVKFMNDKYPEIKIISLDKLTYA
CHHHHHHHHHHHHCCCHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECEEEC
GNKANLSEMAECKNHLFVQGNILDKSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFL
CCCCCHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
ETNVIGTFTLLEAARIYWLNERQWDKSKCRFHHVSTDEVYGSLEREEPAFTEKNSYQPNS
EECCHHHHHHHHHHHHEEECCCCCCCHHCEEECCCHHHHHCCCCCCCCCCCCCCCCCCCC
PYSASKASSDHIVRAYYHTYGLPVTTSNCSNNYGPNQHKEKLIPKVVYACVNQLPITVYG
CCCCCCCCCCCEEEEEHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
NGSNIRDWLYVMDHCEAIDTIIQKGVLGEVYNIGGNNELDNLSLIKMICQMMDDLKPMEK
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHCCHHHH
PYHSLITFVEDRKGHDKRYAIDNSKIQKELGWVPQGDFVHKLSNTVQYYLTRYEHEINV
HHHHHHHHHHHCCCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]