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The map label for this gene is rmlD [C]

Identifier: 54293741

GI number: 54293741

Start: 900379

End: 901263

Strand: Direct

Name: rmlD [C]

Synonym: lpl0794

Alternate gene names: 54293741

Gene position: 900379-901263 (Clockwise)

Preceding gene: 54293740

Following gene: 54293742

Centisome position: 26.91

GC content: 37.74

Gene sequence:

>885_bases
ATGAAAATATTGGTTACAGGTGCTAATGGGCAAGTTGGTACCGAGATTATCAAGCGGTTTTCTTCTTCTGAGCATGAAGT
ATCTCCTTGTACCAGAGATATTCTAGATTGTTTCAAACTCGAACGGGTTCAAGATGTGTTATCGGAAATCAAACCGGATC
TTATCATTAATGCAGCGGCCTATACGGCTGTAGATAAGGCAGAGGATGAACCTGATTTAGCTCATATTGTGAACGCCGAA
TTTGTCTGTCGCCTGGTCAATTATTGTAGCTTCAAAAACATCCCCTTGATCCATCTTTCAACTGATTATGTATTTGATGG
AGAAAAAGAGGGAGCCTATCATGAAACCGATATTCCGCATCCAGTAAGTACCTATGGGCGTACGAAATGGGAAGGAGAAC
AAGCTATTTTATCCCAACTTAAAAAGTATATTATTTTGCGAGTTAGCTGGGTATTTGGTGAACAAGGGAAAAATTTTGTA
AAAACGATTTTAAATTTGGCTTCCAGCAGAAAAGAATTGAATATTGTTTCAGATCAATGGGGAAGGCCTACTTCAGCTCG
CGATATAGCAAGAGTACTATTTGAAATAGTACAGAAAATCAGCCATTCTTCCTTTGACTATTGGGGGCTTTACCATTATG
CAGGGCAGGGGGTTACCAATTGGCATGAATTTGCAAACGTATTTCTTAATATGGCAAAAGAGAAACAGCTTCTCTTGACT
TTAACCGATTTAAATCCAATTAAATCCGAAGAATATCCTACTAGGGCAACAAGGCCTAAAAATTCGGTACTTGATACAAC
AAAGATAGAAACAATATTGGGTATAAAAAGCTGTAGTTGGAAAAATGATTTGCCAGATGTTATCGACCATTTTACAAAAA
AGTAA

Upstream 100 bases:

>100_bases
TTGGCCATTAGGAGAGCAGGTTCAATTGTCTCCAAAAGACGCTGCAGCCAAACCTTTAAGTTTAATAGATGCTGAACTTT
TACCGAGATATCAAACCTAA

Downstream 100 bases:

>100_bases
GAATCACACTATGAAAAATCAGATGAACAACCTTTTGGTAACTGGAGCTGCGGGTTTTATAGGAAGTAATTTTGTTAAAT
TTATGAACGATAAATACCCG

Product: dTDP-4-keto-L-rhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVSPCTRDILDCFKLERVQDVLSEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCRLVNYCSFKNIPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQWGRPTSARDIARVLFEIVQKISHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK

Sequences:

>Translated_294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVSPCTRDILDCFKLERVQDVLSEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCRLVNYCSFKNIPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQWGRPTSARDIARVLFEIVQKISHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
>Mature_294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVSPCTRDILDCFKLERVQDVLSEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCRLVNYCSFKNIPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQWGRPTSARDIARVLFEIVQKISHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=301, Percent_Identity=28.9036544850498, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI11034825, Length=310, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788352, Length=284, Percent_Identity=36.6197183098592, Blast_Score=191, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33466; Mature: 33466

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGANGQVGTEIIKRFSSSEHEVSPCTRDILDCFKLERVQDVLSEIKPDLIINAAA
CEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
YTAVDKAEDEPDLAHIVNAEFVCRLVNYCSFKNIPLIHLSTDYVFDGEKEGAYHETDIPH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCCCCCCCC
PVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFVKTILNLASSRKELNIVSDQW
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHCEEHHCCC
GRPTSARDIARVLFEIVQKISHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKILVTGANGQVGTEIIKRFSSSEHEVSPCTRDILDCFKLERVQDVLSEIKPDLIINAAA
CEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
YTAVDKAEDEPDLAHIVNAEFVCRLVNYCSFKNIPLIHLSTDYVFDGEKEGAYHETDIPH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCCCCCCCC
PVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFVKTILNLASSRKELNIVSDQW
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHCEEHHCCC
GRPTSARDIARVLFEIVQKISHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]