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The map label for this gene is gor [H]

Identifier: 54293562

GI number: 54293562

Start: 667089

End: 668447

Strand: Reverse

Name: gor [H]

Synonym: lpl0614

Alternate gene names: 54293562

Gene position: 668447-667089 (Counterclockwise)

Preceding gene: 54293563

Following gene: 54293561

Centisome position: 19.98

GC content: 39.22

Gene sequence:

>1359_bases
ATGAAAACAAAACATTTTGACCTTATAGTTCTTGGAGGAGGAAGTGGCGGAATAGCCAGTGCTGTTCGTGCTGCTCAGTA
TGGAGCCAAAGTGGCGGTTATTGAGCAAAACCACTTGGGAGGGACCTGCGTGAATTTAGGATGTGTCCCCAAAAAAATTA
TGTACAATGCTTCATCGATTGCAGAAACACTCCATAAATCTCCTGATTACGGTTTTTTCCTGGAAAACAATGCCAAGTTA
GATTGGAAGCGACTAGTGAATAAACGCAATGCGTATATTGAACGTTTAAGAGAAAATTATGCGCAACGATTTTCACAGCA
CAAAATTACTCTGATTCAAGGTAAGGGCATTTTCCACGATCAAAGTTCTATCACGATAGATCATACTATTTATCAAGCAG
AACATATTATTATTGCAACTGGCGGTGAGCCAGCTCTACCAGCAATTAATGGCATTAAGCATGCTATTGATTCTGATGGT
TTTTTTTCATTAACCAAATTACCAGCTAAGGTAGCTGTTATTGGTAGCGGTTACATAGGTGTTGAATTAGCAGGAATCCT
TAACTCTCTTGGTAGTGAAACTCATTTGTTAATGAGAGGTACACGACCACTGAGTCGCTTTGATCATATGATTGGCGACA
CTTTAATGGAAATTATGCAAAAACAAGGAATCTGTATTCACCAAAACCATAAAGCCCAAGCTATCCATCTCCATAGCGAC
GGCAGAAAAAGTATTTTGTGTCAAAGTGGCTCTATTATTGGAAATATTGATGTCATTATATCTGCTGTAGGTCGAAAACC
GCGGACTGGCAATTTAAATCTTGATAAAATAAACGTTATCACGGATGACAAAGGATTAATCCTGGTTGATGCATTCCAAA
ATACATCGGTTAAAGGGGTTTATGCTATTGGCGATGTCACTAATGCTCCCGCATTAACTCCTGTAGCAATAGCGGCGGGG
AGGCGTTTGGCAGACCGAATTTTCGGGAATCAACCTGATGCCTGCTTAAATTATGATAATATCTGTTCAGTAGTATTCTC
TCATCCTCCATCTGGTTCTGTCGGTTTAACCGAGTATGAAGCCATTGAAAAATATGGTAAGAATAAAATTAAAATATATC
AAACCCGTTTCATCCCTATGTATGATGCCTTGAGTATTGATAAAACCCCTACTGCGATGAAATTGGTTACCTTGGGTAAA
AAGGAAAAGATTATTGGTTTACATGTCGTCGGATACAGCGCCGATGAAATGCTACAAGGCTTTGGGGTTGCTATAAAAAT
GGGCGCATGTAAAAAGGACTTCGATAATACAATTGCAATTCATCCAACCAGCGCTGAAGAATTTGTAACTATGGTGTAA

Upstream 100 bases:

>100_bases
GAAATTAAAAAATATTTTGGTTTTTTATAAAATTCAGTTTAATCCCTTGGTAGACCAAGTACGACCTGCTACTATTATTT
TATTTTCCTATTAATTGACT

Downstream 100 bases:

>100_bases
ATATACATGAACTATTCCATTCGTAAATTTGAAGACAAGTATCCTGAATTAGGTGAACGAGTTTATATTGATCCGCAATC
CACTGTCATTGGTAACGTAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAKL
DWKRLVNKRNAYIERLRENYAQRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDG
FFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
GRKSILCQSGSIIGNIDVIISAVGRKPRTGNLNLDKINVITDDKGLILVDAFQNTSVKGVYAIGDVTNAPALTPVAIAAG
RRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEYEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGK
KEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV

Sequences:

>Translated_452_residues
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAKL
DWKRLVNKRNAYIERLRENYAQRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDG
FFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
GRKSILCQSGSIIGNIDVIISAVGRKPRTGNLNLDKINVITDDKGLILVDAFQNTSVKGVYAIGDVTNAPALTPVAIAAG
RRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEYEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGK
KEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
>Mature_452_residues
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAKL
DWKRLVNKRNAYIERLRENYAQRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDG
FFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
GRKSILCQSGSIIGNIDVIISAVGRKPRTGNLNLDKINVITDDKGLILVDAFQNTSVKGVYAIGDVTNAPALTPVAIAAG
RRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEYEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGK
KEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=47.3799126637555, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI22035672, Length=457, Percent_Identity=33.9168490153173, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=34.5054945054945, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=34.5054945054945, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=34.5054945054945, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=34.5054945054945, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=34.5054945054945, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=32.1663019693654, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=29.3216630196937, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=29.6052631578947, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=51.3333333333333, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=27.7161862527716, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.0485651214128, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=27.5488069414317, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=48.8888888888889, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=48.8888888888889, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=34.5991561181435, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=473, Percent_Identity=28.7526427061311, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=45.9227467811159, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=27.8969957081545, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=25.4777070063694, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=33.7552742616034, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=33.6864406779661, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=33.6864406779661, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=33.6864406779661, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=28.2051282051282, Blast_Score=172, Evalue=6e-43,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49081; Mature: 49081

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSI
CCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHCCHHHH
AETLHKSPDYGFFLENNAKLDWKRLVNKRNAYIERLRENYAQRFSQHKITLIQGKGIFHD
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEC
QSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDGFFSLTKLPAKVAVIGSGYIG
CCCEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCEEEEEEECCCHH
VELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECC
GRKSILCQSGSIIGNIDVIISAVGRKPRTGNLNLDKINVITDDKGLILVDAFQNTSVKGV
CCCEEEEECCCEEEEHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEE
YAIGDVTNAPALTPVAIAAGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEYE
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHEEHEECCCCCCCCCCHHHH
AIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGKKEKIIGLHVVGYSADEMLQG
HHHHHCCCEEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHC
FGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
CCEEEEECCCCCCCCCEEEEECCCHHHHEECC
>Mature Secondary Structure
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQNHLGGTCVNLGCVPKKIMYNASSI
CCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHCCHHHH
AETLHKSPDYGFFLENNAKLDWKRLVNKRNAYIERLRENYAQRFSQHKITLIQGKGIFHD
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEC
QSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDGFFSLTKLPAKVAVIGSGYIG
CCCEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCEEEEEEECCCHH
VELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECC
GRKSILCQSGSIIGNIDVIISAVGRKPRTGNLNLDKINVITDDKGLILVDAFQNTSVKGV
CCCEEEEECCCEEEEHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEE
YAIGDVTNAPALTPVAIAAGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEYE
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHEEHEECCCCCCCCCCHHHH
AIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGKKEKIIGLHVVGYSADEMLQG
HHHHHCCCEEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHC
FGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
CCEEEEECCCCCCCCCEEEEECCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]