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The map label for this gene is ykgC [H]

Identifier: 54293250

GI number: 54293250

Start: 338331

End: 339725

Strand: Reverse

Name: ykgC [H]

Synonym: lpl0298

Alternate gene names: 54293250

Gene position: 339725-338331 (Counterclockwise)

Preceding gene: 54293251

Following gene: 54293249

Centisome position: 10.15

GC content: 44.3

Gene sequence:

>1395_bases
ATGGTTTTAGAGTTTGATACCATCATATTAGGTGGGGGCAAAGGTGGGAAGACTCTTGCAATGGATTTGGCTAAAAGCGG
CCAGAAAATCGCGATGGTTGAAAACAATCAGATTGGCGGGACCTGTATCAATGTAGCATGCATACCTACGAAAACGCTCG
TGCAGTCAGCTAAAGTGGCACATTACTGCCGTAAAGCAAAAGACTATGGTTTAAATACCACATTGAGTCCAATTGATTTT
AAAGCAATTCGAGCACGTAAAGACGCTGTGGTGAATGGGATGCGTGAAGCGAATTTAAAACAATTTTTAGATTCGGGCAT
GGATCTCATGTTAGGACATGGTCATTTTATTGGACCAAAAATGATTGAAGTTACCCTATCCTCACCACGTGACAATCAAA
AAACGCTGCACATCACAGCTGATAAAATTATTATTAATACAGGCGCCCTGCCTTACACTCCCCCCATTGCGGGGCTTGAT
AAAGTCAATTATTTTACCAATGACAGTTTAATGAACACCGATTCGGTACCCCAACATTTATTGATCATCGGCGGCGGTTA
TATTGGCTTGGAATTTGCACAAATGTTTCGCCGGTTTGGCGCTGAAGTCACCGCCATCGAAGCCAGTAGCGAATTTCTTG
GCCGGGAAGACAAAGACATTGCTGAACAGGTTTTTCAAATCTTATCCAATGAAGGCATTCAATTTGCTGTCGATACAAAG
ATTAATGCCATTCGCCAAGAGAAAACCGAAGTGATTATCGAAGCTAATCGCCAAGGCCAATCAGAAATTATTCGTGGCAC
AGCTGTCCTTGTTGCAGTAGGGCGTATTGCCAATACAGCAGGATTGCATTTGGATAGAACTGGCGTTGAACTTGATGAAC
GTGGATTCATCAAAGTCAATGAGTTTCTCGAAACGACAGCGGCAGGGATTTGGGCATTGGGCGATGTCAAGGGAGGGGCA
CAGTTTACCCACCTGTCTCTTGATGACTATCGTCTGGTGAAACATAATTTACAAAACCCCCAGAAAAAGCTTTCTTCCCA
AAACAGGCTTATTCCTTACACAGTGTTTCTCGACCCGGAATTAGCACGCATTGGACTTACTGAAGCTCAAGCCAGATCCC
AAGGCCGCCCAATTAAAATCGCCACAATTCCGGCAGCTGCGATTCCTCGCGCCAAAACCCAAGGAGAAACAACGGGTGTT
TTAAAAGCAGTCATTGACGCTGAAACCGATTTGATTTTGGGCGTTTCTATTTTCTGTGCGGAGGCAGGGGAAATATTAGG
GGTCATCCAATTAGCAATGGAGTTGCGCGTACCTTATCAAAAATTGCGCGATATGATGTTCGCTCACCCTACTCTGGTGG
AAGGCATCAATCTGTGGTTTGCGCAAATAATTTGA

Upstream 100 bases:

>100_bases
ATTTTTTATCGCCTTGCGTGAGCTTTCCTCTTTAATTCAAGTATTGTAAATAAGGATCATCATCAAGTGGATAAAACATT
GAAACTTTCGGGAGAATGGA

Downstream 100 bases:

>100_bases
ATTGATGTAAACCATACTCGCCATATTACATGCTACAAGGCAAGTGGTTAATAAAGGCATTTTACTTCACTTTTTCAATA
AATCCTGTGTATAGGCAGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLSPIDF
KAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLD
KVNYFTNDSLMNTDSVPQHLLIIGGGYIGLEFAQMFRRFGAEVTAIEASSEFLGREDKDIAEQVFQILSNEGIQFAVDTK
INAIRQEKTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDRTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRPIKIATIPAAAIPRAKTQGETTGV
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII

Sequences:

>Translated_464_residues
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLSPIDF
KAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLD
KVNYFTNDSLMNTDSVPQHLLIIGGGYIGLEFAQMFRRFGAEVTAIEASSEFLGREDKDIAEQVFQILSNEGIQFAVDTK
INAIRQEKTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDRTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRPIKIATIPAAAIPRAKTQGETTGV
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII
>Mature_464_residues
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLSPIDF
KAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLD
KVNYFTNDSLMNTDSVPQHLLIIGGGYIGLEFAQMFRRFGAEVTAIEASSEFLGREDKDIAEQVFQILSNEGIQFAVDTK
INAIRQEKTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDRTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRPIKIATIPAAAIPRAKTQGETTGV
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=29.3103448275862, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=26.4957264957265, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=24.7288503253796, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI33519430, Length=439, Percent_Identity=25.0569476082005, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519428, Length=439, Percent_Identity=25.0569476082005, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519426, Length=439, Percent_Identity=25.0569476082005, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277065, Length=439, Percent_Identity=25.0569476082005, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI148277071, Length=439, Percent_Identity=25.0569476082005, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI291045266, Length=439, Percent_Identity=26.1958997722096, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI291045268, Length=435, Percent_Identity=24.5977011494253, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI65787454, Length=187, Percent_Identity=24.0641711229947, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI21389617, Length=187, Percent_Identity=24.0641711229947, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI226437568, Length=187, Percent_Identity=24.0641711229947, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=40.0862068965517, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=30.242825607064, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=26.8131868131868, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789915, Length=437, Percent_Identity=27.0022883295195, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=30.5194805194805, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=27.6729559748428, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=384, Percent_Identity=28.6458333333333, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=384, Percent_Identity=28.6458333333333, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=26.0416666666667, Blast_Score=118, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=30.4255319148936, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=25.2136752136752, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=24.1090146750524, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=29.8474945533769, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=26.7223382045929, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=26.5135699373695, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=26.7223382045929, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17737741, Length=488, Percent_Identity=23.9754098360656, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 50607; Mature: 50607

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVA
CEEEEEEEEEECCCCCCEEEEHHHHCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHH
HYCRKAKDYGLNTTLSPIDFKAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCCCE
MIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLDKVNYFTNDSLMNTDSVPQHL
EEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEE
LIIGGGYIGLEFAQMFRRFGAEVTAIEASSEFLGREDKDIAEQVFQILSNEGIQFAVDTK
EEEECCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCCEEEECCH
INAIRQEKTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDRTGVELDERGFIKVN
HHHHHHCCCEEEEEECCCCCHHHHHHHEEEEEHHHHCCCCCCEEECCCCCCCCCCCEEHH
EFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPE
HHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHCCCCCEEEEEEEECCC
LARIGLTEAQARSQGRPIKIATIPAAAIPRAKTQGETTGVLKAVIDAETDLILGVSIFCA
HHHCCCCHHHHHCCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
EAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLEFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVA
CEEEEEEEEEECCCCCCEEEEHHHHCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHH
HYCRKAKDYGLNTTLSPIDFKAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCCCE
MIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLDKVNYFTNDSLMNTDSVPQHL
EEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEE
LIIGGGYIGLEFAQMFRRFGAEVTAIEASSEFLGREDKDIAEQVFQILSNEGIQFAVDTK
EEEECCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCCEEEECCH
INAIRQEKTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDRTGVELDERGFIKVN
HHHHHHCCCEEEEEECCCCCHHHHHHHEEEEEHHHHCCCCCCEEECCCCCCCCCCCEEHH
EFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPE
HHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHCCCCCEEEEEEEECCC
LARIGLTEAQARSQGRPIKIATIPAAAIPRAKTQGETTGVLKAVIDAETDLILGVSIFCA
HHHCCCCHHHHHCCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
EAGEILGVIQLAMELRVPYQKLRDMMFAHPTLVEGINLWFAQII
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]