Click here to switch to the map view.

The map label for this gene is serC

Identifier: 54297328

GI number: 54297328

Start: 1530058

End: 1531146

Strand: Direct

Name: serC

Synonym: lpp1373

Alternate gene names: 54297328

Gene position: 1530058-1531146 (Clockwise)

Preceding gene: 54297327

Following gene: 54297329

Centisome position: 43.67

GC content: 37.47

Gene sequence:

>1089_bases
ATGAATAGCAGGGTTTTCAATTTTGGAGCTGGCCCTGCTATGCTGCCCGAGGAAATATTAAAAGAGGCTCAAGAGGAATT
CCTTAATTGGCGTAATACTGGAATGTCCATACTTGAAATAGGGCATAGGACACCGGAGATCATTAATCTTTTAAGTACTG
CGGAGCAATCGTTAAGAGAGCTGTTAAATATCCCTAAAAATTATCATGTATTGTTTTTAGGAGGAGCAGCTCGAGCACAA
TTTGCCATGATCCCTATGAATTTATTACAGCCAGGGGATGAGGCGGCTTATTTTATTACTGGAATCTGGTCTAAGATGGC
TTATCATGAAGCGAATCTTCTAAAACAAGCATATTATCTTAGCAATGAAGAGAAAGAGGGATTTGTATCAATTCCGGATT
ATCAAAAGTGGGAATTAAAAAGTAATACACCTTATGTCTATTATACCCCAAATGAAACAATTAATGGAGTCAGATTTCCT
TATGTTCCTAAAACAGGAGGGGTTCCTTTAGTCGCGGATATGACTTCTTGCTTGCTGAGCGAGCCGATAAATATTAATCA
ATATGGTTTGATTTTTGCTGGTGCGCAGAAGAACATTGCCAATGCAGGTTTAACTATAGTTATCATTCATGAGGATTTAC
TAAAAAACCAACCTGAACCAGCGATTCCTACCATGTTGAATTATAAAAATCATGCCGAACATCGCTCCTTATATGCTACA
CCACCAGTATTTAATTGTTATTTGGCAAGTAAAATGTTCGAGTGGATAAAAACTCAGGGAGGTATAGAAGGAGTATTTCA
AAGGAATTGTTTGAAAGCCGCGAAGTTATATCAATATCTTGATTCAACTGATTTTTATCTAACTCCAGTATCTAAAGAAG
CTCGTTCTATAATGAATATTTGTTTTTCCCTCTGCTATCCTGATTTGGAACAAAAATTCCTCGATATGGCTAATAAGCGT
GGGTTAAAGGCTTTAAAAGGTCATCGTTTCACTGGAGGATTGCGAGCCAGTTTGTACAATGCCATGCCTATGGCTGGAGT
TGATGCTCTCATTGAGTTTATGTCTGAATTTGCAAAAGAAAATGGTTAA

Upstream 100 bases:

>100_bases
AGTTCTGGTGAGACAGTTGTTGGAATGCAAAAAATTGTAGATCTTGGAGAAGAATTAGAAGAAGCAGAAGATTCATCTCT
TAATGCCGAAGACAACAGTG

Downstream 100 bases:

>100_bases
TAAGCATGTTGAATTTTATAAGTAAACCAGTTGGCTGCCTTAAGGGCGAAATCACAGTACCTGGAGATAAATCCATTTCC
CATCGTTCTATTATTTTTGG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIINLLSTAEQSLRELLNIPKNYHVLFLGGAARAQ
FAMIPMNLLQPGDEAAYFITGIWSKMAYHEANLLKQAYYLSNEEKEGFVSIPDYQKWELKSNTPYVYYTPNETINGVRFP
YVPKTGGVPLVADMTSCLLSEPININQYGLIFAGAQKNIANAGLTIVIIHEDLLKNQPEPAIPTMLNYKNHAEHRSLYAT
PPVFNCYLASKMFEWIKTQGGIEGVFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNICFSLCYPDLEQKFLDMANKR
GLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG

Sequences:

>Translated_362_residues
MNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIINLLSTAEQSLRELLNIPKNYHVLFLGGAARAQ
FAMIPMNLLQPGDEAAYFITGIWSKMAYHEANLLKQAYYLSNEEKEGFVSIPDYQKWELKSNTPYVYYTPNETINGVRFP
YVPKTGGVPLVADMTSCLLSEPININQYGLIFAGAQKNIANAGLTIVIIHEDLLKNQPEPAIPTMLNYKNHAEHRSLYAT
PPVFNCYLASKMFEWIKTQGGIEGVFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNICFSLCYPDLEQKFLDMANKR
GLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG
>Mature_362_residues
MNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIINLLSTAEQSLRELLNIPKNYHVLFLGGAARAQ
FAMIPMNLLQPGDEAAYFITGIWSKMAYHEANLLKQAYYLSNEEKEGFVSIPDYQKWELKSNTPYVYYTPNETINGVRFP
YVPKTGGVPLVADMTSCLLSEPININQYGLIFAGAQKNIANAGLTIVIIHEDLLKNQPEPAIPTMLNYKNHAEHRSLYAT
PPVFNCYLASKMFEWIKTQGGIEGVFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNICFSLCYPDLEQKFLDMANKR
GLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=40.9972299168975, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=36.1344537815126, Blast_Score=242, Evalue=4e-64,
Organism=Escherichia coli, GI1787136, Length=362, Percent_Identity=43.0939226519337, Blast_Score=316, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17506897, Length=362, Percent_Identity=40.6077348066298, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324758, Length=388, Percent_Identity=36.5979381443299, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI21356589, Length=366, Percent_Identity=40.4371584699454, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_LEGPA (Q5X5E7)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123697.1
- ProteinModelPortal:   Q5X5E7
- SMR:   Q5X5E7
- STRING:   Q5X5E7
- GeneID:   3116490
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1373
- LegioList:   lpp1373
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   LPNE297246:LPP1373-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40832; Mature: 40832

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 43-43 BINDING 103-103 BINDING 153-153 BINDING 173-173 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIINLLSTAEQSLRE
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
LLNIPKNYHVLFLGGAARAQFAMIPMNLLQPGDEAAYFITGIWSKMAYHEANLLKQAYYL
HHCCCCCEEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SNEEKEGFVSIPDYQKWELKSNTPYVYYTPNETINGVRFPYVPKTGGVPLVADMTSCLLS
CCCCCCCCEECCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
EPININQYGLIFAGAQKNIANAGLTIVIIHEDLLKNQPEPAIPTMLNYKNHAEHRSLYAT
CCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHCCCCCCCCCHHHCCCCCHHHCCEECC
PPVFNCYLASKMFEWIKTQGGIEGVFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNI
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
CFSLCYPDLEQKFLDMANKRGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKE
HHHHCCCHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NG
CC
>Mature Secondary Structure
MNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIINLLSTAEQSLRE
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
LLNIPKNYHVLFLGGAARAQFAMIPMNLLQPGDEAAYFITGIWSKMAYHEANLLKQAYYL
HHCCCCCEEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SNEEKEGFVSIPDYQKWELKSNTPYVYYTPNETINGVRFPYVPKTGGVPLVADMTSCLLS
CCCCCCCCEECCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
EPININQYGLIFAGAQKNIANAGLTIVIIHEDLLKNQPEPAIPTMLNYKNHAEHRSLYAT
CCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHCCCCCCCCCHHHCCCCCHHHCCEECC
PPVFNCYLASKMFEWIKTQGGIEGVFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNI
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
CFSLCYPDLEQKFLDMANKRGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKE
HHHHCCCHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA