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The map label for this gene is licA [H]

Identifier: 54297318

GI number: 54297318

Start: 1517653

End: 1518804

Strand: Direct

Name: licA [H]

Synonym: lpp1363

Alternate gene names: 54297318

Gene position: 1517653-1518804 (Clockwise)

Preceding gene: 54297316

Following gene: 54297320

Centisome position: 43.32

GC content: 37.07

Gene sequence:

>1152_bases
ATGACGTTTATGAAATTATATTTTTTTGGTGATGATAATAATAAACCCAAATTAAGCGAACATTTAATCATTTACATACT
CAGTTTGCTAGATCCTAAGTCTCAGTCTGTTGCTTCTTTAGTGAATAAAGACTGGTCTCAGCTGGTTCAATTGACACGGC
AATACCTGTCTATGTTACCGGTGATTCATCGAATACCTTTATTTGCGAATTTGGGTCTTGACGTTTTGAAATTAAAATTA
ATGACAGGTGGTATGACGAATTCCACATTTAGGCTAAGAATCAAAAATGCGCCTGAGAAATGGGTTATGCGGATTCCTGG
AATAGGCTCTTCAGCATTTATAACCAGAAGAGATGAGGCTCACAATGCTAAACAAGCCGAAAAACTTGGACTGAATGTTC
CAATAGCTTTCTTTGATCCAGAAGATGGGCTGCAGGTAACACGCTTTATAGAAGGAGTGCATTCTCTGGATGATAAAGCT
TTGGCCCGCAAGGAAATTCTGCATGAGGTAGCATCTATGATGAGAAGACTTCATAAATCTCCTCCTTTTGATAATAACAC
GCTTTTTTTTGAGCGAAATGAAGAGTTATTGGATTTATTAAAACGAAAACCCTTTAATTTCCCAGGGGAAATAGAATTTA
TTGAGCAACAAATGAAAAATCTAAAGGAGATTTTTTCTTCTTATCGTATTCAGCAATTTCCTTGCCACAATGATACAACG
CCACTTAATTTTATCTTGTCCGAAAATCCAGAAATCAAGGGTTCTGAAAAGATTCATCAGATTGATTGGGAATATTCAAG
TAATAATGATTTTATTTGGGATTTGGCTTATTTTATGGTTGAGGCCAAGCTAAACCGTGAACAACAGCTTATTCTGTTGA
AAGCTTACTTTAATACAGAAGAGCTGAGCGGCTCTCTGTTGGCATGGATAGAGGTTTATAAACCCATCATTGAGTGGTGG
ATAACCATTTGGTCATGGACACAATTGGCAAATGGAGCTAATGCAGTTGATTTGAGTTCTTATGAGCAACTAGGGCTTGA
ACGGTATCATAACACCTTAAGTCACTTGAAAAGTGAGGACTATGTCAAAGCCTTGGCATTGATTGAAGCAGATAGTCATA
GCCTTACTTTTACGGGGCATAGACTTTTTTAG

Upstream 100 bases:

>100_bases
TGCAAAAACATTCAGTATTCCCTGGAAAGTAATGATGAATTGTATGTTATTTTATTATCAGTTTTTATATAATGCATTCA
GTTTTATCATTAATTAATAA

Downstream 100 bases:

>100_bases
CGGTCGCCATTATCTAGACAGGACAACTCGTTTATAGTGACGATTAAGATCTTCAGAGCATTTTTTTGAGAAATTCCTGT
AAATGCATCTTGTCTTTCTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSQLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKL
MTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKA
LARKEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKPFNFPGEIEFIEQQMKNLKEIFSSYRIQQFPCHNDTT
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLAYFMVEAKLNREQQLILLKAYFNTEELSGSLLAWIEVYKPIIEWW
ITIWSWTQLANGANAVDLSSYEQLGLERYHNTLSHLKSEDYVKALALIEADSHSLTFTGHRLF

Sequences:

>Translated_383_residues
MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSQLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKL
MTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKA
LARKEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKPFNFPGEIEFIEQQMKNLKEIFSSYRIQQFPCHNDTT
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLAYFMVEAKLNREQQLILLKAYFNTEELSGSLLAWIEVYKPIIEWW
ITIWSWTQLANGANAVDLSSYEQLGLERYHNTLSHLKSEDYVKALALIEADSHSLTFTGHRLF
>Mature_382_residues
TFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSQLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKLM
TGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKAL
ARKEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKPFNFPGEIEFIEQQMKNLKEIFSSYRIQQFPCHNDTTP
LNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLAYFMVEAKLNREQQLILLKAYFNTEELSGSLLAWIEVYKPIIEWWI
TIWSWTQLANGANAVDLSSYEQLGLERYHNTLSHLKSEDYVKALALIEADSHSLTFTGHRLF

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 44558; Mature: 44427

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSQLVQLTRQYLSMLP
CCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIHRIPLFANLGLDVLKLKLMTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEA
HHHHCCHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEECCCCCCCCEEEECCHH
HNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALARKEILHEVASMMRRLHKS
CCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
PPFDNNTLFFERNEELLDLLKRKPFNFPGEIEFIEQQMKNLKEIFSSYRIQQFPCHNDTT
CCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLAYFMVEAKLNREQQLILLKAYFNTE
CEEEEECCCCCCCCCCCEEEEECEECCCCCEEHHHHHHHHHHHCCCCCEEEEEEEECCHH
ELSGSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGLERYHNTLSHLKSED
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
YVKALALIEADSHSLTFTGHRLF
HHHHHHHEECCCCEEEEECCCCC
>Mature Secondary Structure 
TFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSQLVQLTRQYLSMLP
CEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIHRIPLFANLGLDVLKLKLMTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEA
HHHHCCHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEECCCCCCCCEEEECCHH
HNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALARKEILHEVASMMRRLHKS
CCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
PPFDNNTLFFERNEELLDLLKRKPFNFPGEIEFIEQQMKNLKEIFSSYRIQQFPCHNDTT
CCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
PLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLAYFMVEAKLNREQQLILLKAYFNTE
CEEEEECCCCCCCCCCCEEEEECEECCCCCEEHHHHHHHHHHHCCCCCEEEEEEEECCHH
ELSGSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGLERYHNTLSHLKSED
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
YVKALALIEADSHSLTFTGHRLF
HHHHHHHEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]