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The map label for this gene is tmk

Identifier: 54297309

GI number: 54297309

Start: 1507480

End: 1508118

Strand: Direct

Name: tmk

Synonym: lpp1354

Alternate gene names: 54297309

Gene position: 1507480-1508118 (Clockwise)

Preceding gene: 54297308

Following gene: 54297310

Centisome position: 43.03

GC content: 37.56

Gene sequence:

>639_bases
ATGTCATCGTTAACCGGGAAATTGATAGTTATTGAAGGTTTGGAGGGGGCAGGAAAATCTACAGCTGTCAATTTAGTTGT
TGAACTGTTATCCCAAAAAAAAATCAGTACTATAACCACGAGAGAACCCGGAGGAACAAGAATAGGTGAAATTTTAAGAA
GTATTATTAAAAATCCAGAGTACAATAATGTTCTGGATGACAGAAGCGAATTACTTCTCCTGTATGCCGCAAGGATACAA
CTGATTGAGCAAGTGATCAAACCCGCTTTAAATGTGGGGCAGTGGGTCATAGCTGATCGATTTGAGCTTTCCACTTTAGC
TTATCAGGGAGGGGGCCGCAAAATGAATATGCGGGTTATTAATGAGCTATCGAATTTCTGTTTAAAAGGATTCAAACCTG
ATCTTACTTTATATTTAGACATTAATCCCGAGCTTGGCATGATAAGAGCTAAATCAAGGGGAAAATTTGACAGGATTGAG
CAGGAGTCAATTGAGTTTTTTCATAGAATACATGATACATATCATGTTCTTGTTAAACAAAACCCGGAAATTATGATGAT
TGATGCTAACAGGTCTTTGGATGAGGTTCAATCTTCCATTCAATCAGTAATCGAGGAGTTTATAGAGCATAACCTATGA

Upstream 100 bases:

>100_bases
ATTTATACTTTGTTGCCAAAGGAGATGGCACTCATCAATTCTCCGAAACTTATGAGCAACAAAGACAAGCGATTAATCAA
TACAGACGCAAGGATTATTA

Downstream 100 bases:

>100_bases
TTACTTATCAAGAACAATGGCAGAAAATGCAAATGGCCTTGGCGGTAAGACGAATTCCTCAAGCCATGCTATTTTTGGGT
TCTTTGCATTGTGGTCTTAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMNMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHVLVKQNPEIMMIDANRSLDEVQSSIQSVIEEFIEHNL

Sequences:

>Translated_212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMNMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHVLVKQNPEIMMIDANRSLDEVQSSIQSVIEEFIEHNL
>Mature_211_residues
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQL
IEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMNMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQ
ESIEFFHRIHDTYHVLVKQNPEIMMIDANRSLDEVQSSIQSVIEEFIEHNL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=214, Percent_Identity=29.9065420560748, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=50, Blast_Score=207, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322517, Length=216, Percent_Identity=27.3148148148148, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573735, Length=207, Percent_Identity=28.9855072463768, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_LEGPA (Q5X5G6)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123678.1
- ProteinModelPortal:   Q5X5G6
- STRING:   Q5X5G6
- GeneID:   3116906
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1354
- LegioList:   lpp1354
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   LPNE297246:LPP1354-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24027; Mature: 23896

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPE
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMNMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCHHHHHHEECCCCCEEHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHVLVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
NPEIMMIDANRSLDEVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMNMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCHHHHHHEECCCCCEEHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHVLVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
NPEIMMIDANRSLDEVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA