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The map label for this gene is hutU [H]

Identifier: 54297289

GI number: 54297289

Start: 1489095

End: 1490759

Strand: Direct

Name: hutU [H]

Synonym: lpp1334

Alternate gene names: 54297289

Gene position: 1489095-1490759 (Clockwise)

Preceding gene: 54297285

Following gene: 54297290

Centisome position: 42.5

GC content: 43.48

Gene sequence:

>1665_bases
ATGAACAAGGACAAGAATAAACGTGTTATTTCTGCCCCTAGAGGTACCGAAATTCAAGCTAAAAATTGGTTAACTGAGGC
GGCATTAAGGATGATTTGCAATAATTTGGATCCCAATGTTGCAGAGGATCCCGATTCTTTGATTGTTTATGGTGGATTAG
GCAAGGCAGCCAGAAACTGGGAATGTTTTGATGAAATTGTTCATGTATTAAAATTATTAAATAATGATCAGACTTTACTC
ATTCAGTCCGGAAAACCTGTCGGTGTATTTACTACCCATGAAGAGGCTCCCAGAATACTAATTGCCAATTCTAATTTGGT
ACCGCGCTGGGCTACTTGGGAGCATTTTAACGAACTGGATAAGAAAGGCCTGATGATGTATGGTCAGATGACCGCCGGCA
GCTGGATTTATATTGGTTCTCAAGGCATTGTGCAAGGAACTTATGAGACATTTGTTGCGGCAGCTAAAAAACATTATCAG
GGTGATTTGTCCGGGCGTTGGATTTTAACAGCGGGTTTAGGGGGAATGGGTGGAGCTCAACCTTTAGCTGGAACTATGGC
TGGTGCCAGCGTTCTGGCTGTAGAATGTGACAGGCAAAGGATTGAGAAACGTTTACAGACGAAGTATCTGGATCGGTACA
CTGATAATTTAAGTGAAGCATTAGACTGGATAAATGAATCCTGTCGCTGTAAAAAGCCAGTTTCAGTAGCTGTTTTGGGA
AATGCTGCCGAAATATTTCCTCAGCTGGTTAAGTTGGGAGTTCACCCTTCCCTGGTTACCGATCAAACCAGCGCTCATGA
TCCGCTCAATGGCTATTTGCCATTAGGATGGACATTGGAACAAGCTGTTGAAATGAGAAAAAAATCACCAGAAGAGGTTG
TTGATGCAGCCAAGAAATCGATGGCTGTTCAAGTGCATGCGATGCTTGAGTTTCATAACAGAGGCATTCCTGTATTTGAT
TATGGCAATAACATTAGACAAATGGCATTTGAAGCGGGAGAAAAAAACGCTTTTTCCTTTGAGGGATTTGTACCTGCTTA
TATCAGGCCATTATTTTGCGAAGGAATCGGACCATTTCGATGGGTTGCATTGTCAGGTGATCCAGAAGATATTTATGCAA
CAGATGAGCGAGTAAAGCAGCTAATTCCTGATGATCCTCACTTACATCATTGGTTAGATATGGCCAGGGAAAAAATTTCA
TTTCAAGGATTACCTGCAAGGATATGTTGGGTAGGGTTAAAGGATAGAGCGCGCCTTGCCCTGGCTTTCAATGAAATGGT
TAAAAATAAACAAGTTAAAGCGCCTATTGTGATTGGCCGTGACCATTTGGATTCTGGTTCTGTGGCCAGCCCCAACCGCG
AAACAGAGGGTATGCTGGATGGCAGTGATGCTGTTTCTGATTGGCCTTTGCTTAATGCGCTGTTAAATTGTGCCAGTGGA
GCTACTTGGGTAAGCATTCATCATGGGGGAGGGGTTGGTATGGGCTTTTCTCAACATGCTGGCGTTGTGATCGTTGCTGA
TGGAACAGAAAAAGCGGCTAAACGATTGGCTCGCGTGCTACACAATGATCCTGCGACAGGGGTAATGAGGCATGCTGATG
CAGGTTATCAAATTGCCAAGCAATGTGCCAAAGAGAATTCGCTTTGGTTACCCATGGAATCTTAA

Upstream 100 bases:

>100_bases
CCGGAGGTAGTTGACTGGTGTATGATGCTAAAAAATTTTTTAATCGCTATTTGATAGGAAATAATAACTGAAGTTTTCAT
AGCAATAAGGAGTATTCTTG

Downstream 100 bases:

>100_bases
AAGGAGCAGGTTTATGTCAGAACATTTTATATTGCAGCCTGGTCAGTTATCGCTAGTTTCTATTAAACAAATTTTAGATG
AGGAACTATCTTGCGTTCTT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTLL
IQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQ
GDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVFD
YGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKIS
FQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES

Sequences:

>Translated_554_residues
MNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTLL
IQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQ
GDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVFD
YGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKIS
FQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES
>Mature_554_residues
MNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTLL
IQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQ
GDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVFD
YGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKIS
FQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=554, Percent_Identity=35.1985559566787, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI260306182, Length=614, Percent_Identity=32.7361563517915, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71997891, Length=563, Percent_Identity=35.5239786856128, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61000; Mature: 61000

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNW
CCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCH
ECFDEIVHVLKLLNNDQTLLIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELD
HHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHC
KKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQGDLSGRWILTAGLGGMGGAQ
CCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
PLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
CHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKS
CHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
MAVQVHAMLEFHNRGIPVFDYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFR
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCEE
WVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKISFQGLPARICWVGLKDRARLA
EEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
LAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
HHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAK
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHH
QCAKENSLWLPMES
HHHCCCCEEECCCC
>Mature Secondary Structure
MNKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNW
CCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCH
ECFDEIVHVLKLLNNDQTLLIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELD
HHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHC
KKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQGDLSGRWILTAGLGGMGGAQ
CCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
PLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
CHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKS
CHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
MAVQVHAMLEFHNRGIPVFDYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFR
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCEE
WVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKISFQGLPARICWVGLKDRARLA
EEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
LAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
HHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAK
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHH
QCAKENSLWLPMES
HHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA