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The map label for this gene is hutH

Identifier: 54297290

GI number: 54297290

Start: 1490773

End: 1492293

Strand: Direct

Name: hutH

Synonym: lpp1335

Alternate gene names: 54297290

Gene position: 1490773-1492293 (Clockwise)

Preceding gene: 54297289

Following gene: 54297291

Centisome position: 42.55

GC content: 40.43

Gene sequence:

>1521_bases
ATGTCAGAACATTTTATATTGCAGCCTGGTCAGTTATCGCTAGTTTCTATTAAACAAATTTTAGATGAGGAACTATCTTG
CGTTCTTGCTGAGCACGCCTTTGAATTAATTAGAGCTTCTCACCAAACGGTTAAAAAAGTAATTGATGAAAAGAAAACAG
TATATGGAATCAATACAGGTTTTGGTTCTCTGGCAAACCAGACCATTTCTTCAGATTGTTTGAAAGAGTTGCAGCGTAAT
ATTGTACTTTCTCATGCTTGTGGAACGGGTAAATTATTGCCGGATAGCGTGGTTGCCTTGATTTTGCTTTTGAAAATTAA
TAATTTGTCTCAAGGGTATTCCGGAGTTAGGCTGGAATTAATCAATGCATTGATTGCTTTGTTTAATCATAAGGTATATC
CATGTATTCCCTCTAAGGGTTCGGTAGGTGCGTCCGGAGATTTAGTCCCGCTTGCGCATTTGTCTTTACCTTTGTTAGGA
GAAGGCGAAGTAAGGCATCAAGGTCAGGTGATCAGTGCTGAGGAAGGGCTAAAACTGGCTGGATTGAAACCGCTTGAATT
GGAAGCTAAAGAAGGATTAGCACTGCTTAATGGCTTACAGGTATCTACCGCTTTAGCTTTGTCAGCTCTGTTTATTAGTG
AGACATTGTTCGAAACAGCGATTATTTCCGGCAGTTTGTCAGTAGATGCTGCCAGTGGGAGTGATGTGCCCTTTGATGAC
AGAATACATCAAATTCGAGGACATCAAGCTCAAATTTCTGCTGCCAGCATGTACAGAAATTTATTGGCAGGTAGTCAAAT
TCGAGAGTCACACAGGCATTGTAATCGTGTTCAGGACCCTTATTCTTTAAGATGTCAGCCACAAATCATGGGTGCAGTTC
TTCATCAGATGCAGTTTGTTGGACAAACTCTCCAAGTAGAGGCCAATGCAATTTCCGATAATCCTCTCGTTTTTGCAGAG
CAGGGGGATATTTTGTCTGGGGGAAATTTTCATGGTGAAATCATCGCAATGGCTGCTGACAATTTAGCATTGGCATTATC
CGAGATAGGAGGTAGTGCAGAACGGCGAATCGCTTTATTAATTGATAAGAATTTTAGTGGATTGCCTGCTTTCCTGGTTA
GAGAAAGCGGCTTAAATTCAGGTTTTATGATTGCCCATGTTACTGCTGCCTCCTGTGCCAGTGATAACAAAGCGCTTGCT
CATCCGCACTCTGTTGATAGTTTGCCTACCTCGGCAAATCAGGAAGATCATGTTTCTATGGCAACTAGCGCAGCACGTCG
ATTGCATGAAATGATCGATAATACTTCAACAATTCTTGCTATTGAGTTATTGGCAGCTTGTCAAGGGCTGGAGTTTCATA
AACCTCTAAAGACATCACCGCAATTGGATAAAATTTATCAAAGCGTAAGAAGCGTGGTTAAAGAGTATGATAAAGATCGC
TATTTTGCACCTGATATAGAAAAAATTAAAAAGAAGATTTTAGATAAGGAATTCTCATTACTCACACTCACGAATGAATA
G

Upstream 100 bases:

>100_bases
GGGGTAATGAGGCATGCTGATGCAGGTTATCAAATTGCCAAGCAATGTGCCAAAGAGAATTCGCTTTGGTTACCCATGGA
ATCTTAAAAGGAGCAGGTTT

Downstream 100 bases:

>100_bases
CAGGAAAAATACAATGGAATTGATGACAGAATTTCTAGCTTTGCATCAACAACACAAAAACAATCCTTATCCTTCTTTGT
CTGAAAGAAAAAAATTGCTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSEHFILQPGQLSLVSIKQILDEELSCVLAEHAFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRN
IVLSHACGTGKLLPDSVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLG
EGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
RIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAE
QGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALA
HPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
YFAPDIEKIKKKILDKEFSLLTLTNE

Sequences:

>Translated_506_residues
MSEHFILQPGQLSLVSIKQILDEELSCVLAEHAFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRN
IVLSHACGTGKLLPDSVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLG
EGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
RIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAE
QGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALA
HPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
YFAPDIEKIKKKILDKEFSLLTLTNE
>Mature_505_residues
SEHFILQPGQLSLVSIKQILDEELSCVLAEHAFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRNI
VLSHACGTGKLLPDSVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGE
GEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDDR
IHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQ
GDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAH
PHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRY
FAPDIEKIKKKILDKEFSLLTLTNE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=474, Percent_Identity=47.6793248945148, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17567831, Length=498, Percent_Identity=44.3775100401606, Blast_Score=387, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_LEGPA (Q5X5I5)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123659.1
- ProteinModelPortal:   Q5X5I5
- SMR:   Q5X5I5
- STRING:   Q5X5I5
- GeneID:   3116858
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1335
- LegioList:   lpp1335
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   ELIRASH
- ProtClustDB:   PRK09367
- BioCyc:   LPNE297246:LPP1335-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54680; Mature: 54549

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHFILQPGQLSLVSIKQILDEELSCVLAEHAFELIRASHQTVKKVIDEKKTVYGINTG
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
FGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDSVVALILLLKINNLSQGYSGVRLEL
CHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
INALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLA
HHHHHHHHCCCCEECCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCEEEECCCCCEEC
GLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
CCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHH
RIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFV
HHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALL
CCCEEEEEEECCCCCEEEEECCCEECCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEE
IDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSM
EECCCCCCCHHHEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YFAPDIEKIKKKILDKEFSLLTLTNE
CCCCCHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SEHFILQPGQLSLVSIKQILDEELSCVLAEHAFELIRASHQTVKKVIDEKKTVYGINTG
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
FGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDSVVALILLLKINNLSQGYSGVRLEL
CHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
INALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLA
HHHHHHHHCCCCEECCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCEEEECCCCCEEC
GLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
CCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHH
RIHQIRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFV
HHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALL
CCCEEEEEEECCCCCEEEEECCCEECCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEE
IDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSM
EECCCCCCCHHHEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YFAPDIEKIKKKILDKEFSLLTLTNE
CCCCCHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA