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The map label for this gene is glnS [H]

Identifier: 54297225

GI number: 54297225

Start: 1407267

End: 1408922

Strand: Direct

Name: glnS [H]

Synonym: lpp1270

Alternate gene names: 54297225

Gene position: 1407267-1408922 (Clockwise)

Preceding gene: 54297224

Following gene: 54297226

Centisome position: 40.17

GC content: 39.55

Gene sequence:

>1656_bases
ATGACAGAACAAACTGAAAAAAGAGCTCATTTTATTAGACAACTCATTATAGATGATTTGGCAAATGGAAAACATCAGGG
AATCGTTACTCGTTTTCCTCCTGAACCAAATGGATATCTCCATGTTGGACATGCCAAATCTATTTGTCTTAATTTTGGTT
TGGCAGAAGAGTTTAAGGGAAAATGCTTTTTACGTTTTGATGACACCAATCCAATTAAAGAAGAAGAAGAATATGTAAAC
GCGATCATTGATGATGTTCGTTGGTTGGGATTTGAATGGTGTGCCATGACGCATTCTTCGGATTACTATCATGAGCTGTA
TGAATTAGCCATTTATCTTATTAAGAAAGATATGGCTTATGTCGATAGCCTGAGTATGGAGGAAATTCGTGCTTTTCGCG
GTACTCTACAAGAACCAGGGCGCGAAAGCCCTTATAGAAACAGAACAATCGAAGAGAATCTGGATTTATTCGCTCGGATG
AAAGCTGGTGAGTTTCCTGATGGAACTCATGTTTTGAGAGCAAAAATAGATATGAAATCAGGTAATTTAAATATGCGTGA
TCCGGTTTTATATCGTATACGTCATGCCCGGCACCAGCGTACAGGAGATGAATGGTGTATTTATCCCATGTATGATTATG
CTCATCCTATTTCTGATGCCCTGGAAAAAATAACACATTCTTTATGTACGTTGGAATTCCAGGATCATAGACCTTTGTAT
GATTGGCTGGTTGATAATTTACCTTTGCCTGCCAAACCAGTACAAACCGAATTTGCCAGATTAAATTTATCCCATACTGT
TACGAGCAAGAGAAAATTACGTGAATTGGTTGAAAAAAAAATCGTTACAGGATGGGATGACCCACGATTGCCCACATTAC
GTGGTATGCGCAAAAGGGGATACCCACCTGCTGCAATTCGGCAATTCTGTGAAATAATTGGCATATCAAGAAGTGATTCA
GTGATTGATATGAGTTTACTTGAGGAATGTGTACGCGCTGAATTTAATAAAACTGCAAAACGGGCTCTCTGTGTTATGGA
TCCCTTAAAAGTTGTTATTGTAAATTATCCAGAAAATAAAGTAGAACAGCTTCAAGCAGCTTTCTACCCTCAAAATCCTG
AGTCAGAGAGTAGGAGTTTACCCTTTTCCCGTGAAATTTATATTGAAAAGTCTGATTTTATGGAAAATCCGCCTAATAAA
TATTTCCGGTTATCTCCTGGCGCTGAAGTACGCTTACGTCATGCCTATGTTATAAAGTGCCAGGAAGTTATCCGTAATGA
CCAAGGCGAAATAACAGAATTGCATTGCACTTATGATGAAAATACTCTCGGCAAAAATCCGGAGGATCGCAAGGTGAAGG
GTGTCATTCATTGGGTGTCTTCATCACATGCCTATCCTGTCACTATTTATCAATACGACAGGTTATTTACAGATCCCAAT
CCTGCACGGGAGGATGATTATTTTCAGTTTCTGAACCATAACTCTTTACAAACCCTCCAGGGATTTTGTGAACCGGCAAT
GGCTGAGCAGGCAGAAGGAGATGTGTTTCAATTTGAGCGTTTAGGTTATTATTGCGTCAATTCAGTGGCTGAGGGCTGTG
TTCAAGCCTTTCATCGGGTAGTGGATTTGAAGGACACTTGGGGTAAAGTGAGTTGA

Upstream 100 bases:

>100_bases
AAATCATTGAAGCCTATGAGGCCAAGAAAGATCCGCTACAAGCAAGCGGGGCTCTATTGAGTTCCATGAGGCAAGCTATC
GATAATATTGGAAGTATGGT

Downstream 100 bases:

>100_bases
GAGGCAGACATGTTACATTTATATAATTCTTTGACCAGAAAAAAAGAACCATTTGTTTCCTTAAGGCCCGGAAAGATAGG
TATGTATGTTTGCGGAATTA

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKGKCFLRFDDTNPIKEEEEYVN
AIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAYVDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARM
KAGEFPDGTHVLRAKIDMKSGNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRGYPPAAIRQFCEIIGISRSDS
VIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENKVEQLQAAFYPQNPESESRSLPFSREIYIEKSDFMENPPNK
YFRLSPGAEVRLRHAYVIKCQEVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
PAREDDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRVVDLKDTWGKVS

Sequences:

>Translated_551_residues
MTEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKGKCFLRFDDTNPIKEEEEYVN
AIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAYVDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARM
KAGEFPDGTHVLRAKIDMKSGNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRGYPPAAIRQFCEIIGISRSDS
VIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENKVEQLQAAFYPQNPESESRSLPFSREIYIEKSDFMENPPNK
YFRLSPGAEVRLRHAYVIKCQEVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
PAREDDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRVVDLKDTWGKVS
>Mature_550_residues
TEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKGKCFLRFDDTNPIKEEEEYVNA
IIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAYVDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARMK
AGEFPDGTHVLRAKIDMKSGNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLYD
WLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRGYPPAAIRQFCEIIGISRSDSV
IDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENKVEQLQAAFYPQNPESESRSLPFSREIYIEKSDFMENPPNKY
FRLSPGAEVRLRHAYVIKCQEVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPNP
AREDDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRVVDLKDTWGKVS

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4826960, Length=531, Percent_Identity=42.9378531073446, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI62241042, Length=505, Percent_Identity=35.049504950495, Blast_Score=297, Evalue=2e-80,
Organism=Escherichia coli, GI1786895, Length=556, Percent_Identity=56.294964028777, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1788743, Length=122, Percent_Identity=31.1475409836066, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17543332, Length=531, Percent_Identity=42.5612052730697, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17511007, Length=514, Percent_Identity=34.2412451361868, Blast_Score=265, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6324742, Length=561, Percent_Identity=38.3244206773619, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321192, Length=520, Percent_Identity=34.4230769230769, Blast_Score=294, Evalue=3e-80,
Organism=Drosophila melanogaster, GI17864488, Length=557, Percent_Identity=40.754039497307, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24649466, Length=525, Percent_Identity=33.9047619047619, Blast_Score=281, Evalue=9e-76,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.18 [H]

Molecular weight: Translated: 64117; Mature: 63986

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKG
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECCHHHHHHCCCCHHHCCC
KCFLRFDDTNPIKEEEEYVNAIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAY
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHH
VDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARMKAGEFPDGTHVLRAKIDMKS
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC
GNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHEEEECCCCCHH
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRG
HHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
YPPAAIRQFCEIIGISRSDSVIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENK
CCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
VEQLQAAFYPQNPESESRSLPFSREIYIEKSDFMENPPNKYFRLSPGAEVRLRHAYVIKC
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEECCCCCEEEEHHHHEEH
QEVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHEEEEECCCCCCEEEEEEECHHCCCCC
PAREDDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRV
CCCCCHHHHHHCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLKDTWGKVS
HCCHHCCCCCC
>Mature Secondary Structure 
TEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKG
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECCHHHHHHCCCCHHHCCC
KCFLRFDDTNPIKEEEEYVNAIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAY
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHH
VDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARMKAGEFPDGTHVLRAKIDMKS
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC
GNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHEEEECCCCCHH
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRG
HHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
YPPAAIRQFCEIIGISRSDSVIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENK
CCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
VEQLQAAFYPQNPESESRSLPFSREIYIEKSDFMENPPNKYFRLSPGAEVRLRHAYVIKC
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEECCCCCEEEEHHHHEEH
QEVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHEEEEECCCCCCEEEEEEECHHCCCCC
PAREDDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRV
CCCCCHHHHHHCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLKDTWGKVS
HCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]