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The map label for this gene is lon [H]

Identifier: 54027592

GI number: 54027592

Start: 5956636

End: 5959071

Strand: Reverse

Name: lon [H]

Synonym: nfa56180

Alternate gene names: 54027592

Gene position: 5959071-5956636 (Counterclockwise)

Preceding gene: 54027599

Following gene: 54027589

Centisome position: 98.97

GC content: 71.14

Gene sequence:

>2436_bases
GTGACTACACCTCGTGATCTGCCGGTGCTGTTCCTGACCGATCCGATCGTGCTGCCGGGCATGGTCGTGCCCATCGAACT
GGACGAATCCGCGCAGGCGGCGATCGACGCCGCCCGCGCCGCCGGGACCGACGCCGTGCTGCTGGCGCCCCGCCTCGCCG
AGGGCTACGCCTCCTACGGCGTCATCGCGACCATCGAACAGGTCGGCCGGATGCGGGGCGGCGCGCCCGCGGCCGTGCTG
AAGGCCGAACGCCGCGCCAAGATCGGGCACGGCGTCACCGGCCCCGGGGCGGCGCTGTGGGTCGAGGCCGAGCCGGTCGA
GACCCCGCCCGCCGACGGCCGCACCAAGGAGCTGGCCGCCGAATACAAGAAGCTGGTCGTCTCGGTGTTGCAGCGCCGGG
AGGCCTGGCAGCTGGTCGACGCGGTCAACCAGCTCACCGACGCCTCCGCCATCGCCGACACCGCGGGTTACGCGCCGTAC
CTGACGGCCGAGCAGAAGCGCGAACTGCTGGAGACCCCCGACGTGGCGCAGCGGCTGACCGTGCTGATCGAGTGGACCAA
GGCCTACATCGCCGAGGCCGAGGTCACCGAGAAGATCAGTGACGAGGTCCGCGAGAGCATGGAGAAGAGCCAGCGCGAGT
TCCTGCTGCGCCAGCAGCTCAACGCCATCCGCAAGGAACTCGGCGAGGACGAACCCGACGGCGCCGACGACTACCGCACC
CGCGTCGAGCAGGCCGACCTGCCCGAGGCGGTGCGCGAGGCCGCGTTGCGTGAGGTCGGCAGGCTGGAACGCGCCAGCGA
CCAGAGCCCGGAATCGGGCTGGATCCGCACCTGGCTCGACACTGTGCTGGAACTGCCCTGGCAGGTCAAGACCACCGACA
GCACCGACATCTCGGCCGCCCGCGCGGTCCTGGACGCCGACCACCACGGCCTCGACGAGGTCAAGGACCGGATGGTCGAG
TACCTGGCCGTGCGCGCCCGGCGGGCACAGCGCGGTCTGGAGGTGGTCGGCGGACGCGGGTCCGGCGCGGTGCTGGTGCT
GGTCGGCCCGCCCGGCGTCGGCAAGACCTCGCTGGGTGAGTCGGTGGCGCGGGCGCTCGGGCGCAAGTTCGTGCGCGTCG
CCCTGGGCGGTGTGCGCGACGAGGCCGAGATCCGCGGCCACCGCCGCACCTACGTCGGCGCGCTGCCCGGCCGGATCGTG
CGTGCGATGAAGGAGGCCGGGTCGATGAACCCGGTGGTGCTGCTCGACGAGATCGACAAGGTCGGCTCGGACTTCCGCGG
CGATCCGGCGGCGGCCCTGCTCGAGGTGCTCGATCCCGCGCAGAACCACACCTTCCGCGACCACTACCTCGACCTCGACC
TCGACCTGTCCGACGTGCTGTTCATCGCGACCGCCAACGTCATGGACACCATCCCTGGCCCGCTGCTGGACCGGATGGAG
CTCATCACCGTCGACGGATACACCGAGGCCGACAAGGTGGCCATCGCGCGTGACTTCCTGGTGCCCCGGCAGCTGGAACG
CAACGCGCTGACCGCCGAGGAGGTGCGCATCACCGAGGCGGCGCTGCGCGAGATCGCGGCGAACTACACCCGCGAGGCCG
GTGTGCGCCAGATGGAGCGGCTGATCGCCAAGGCGCTCCGCAAGGCGGCCACCCGGCTGACCGAGAGTGCTTCGGACCCA
GCCGATTCCGACTCCACGGTGACGCCGATCCGCACCGGATACGATCCCGAACTCGGCTACGACGAGGTGGTCACCGACCG
CGGACAGACGCCGCTGACGATCGACGTGGGCGATCTGAAGGAGTACCTGGGCCGGCCGCGTTTCACCCCCGATTCGGTGG
AGCGGACCGCGGTGCCGGGTGTGGCGACCGGGCTCGCGGTGACCGGCGCGGGCGGTGACGTCCTCTACATCGAGGCCAAC
GCCGCCGAGGGTGAGCGCTCGCTGACCCTCACCGGCCAGTTGGGCGATGTCATGAAGGAATCGGCGCAGATCGCGCTGAC
CTACGTGCGTTCGCACCTCGCGGAGATCGGTATCGAGCCGTCGGTGCTGGATCGCAACATCCACATCCACTTCCCGGCGG
GTGCGGTGCCCAAGGACGGTCCGTCCGCCGGCGTGACGATGGTGACCGCGCTGGTCTCGCTGGCGCTGGGCCGCCAGGTC
CGCGCCGATGTCGGGATGACCGGTGAGGTCACCCTGAACGGGCGGGTGCTGCCGATCGGCGGGGTGAAGCAGAAGCTGCT
CGCCGCCCAGCGCGCGGGGTTGAAGACCGTGTTCATCCCGGCCCGGAACGAGCCGGATCTGGACGAGGTCCCCGCCGAGG
TGCTGGCCGCGCTGGACGTGCGTCCGGTCGCCGACGTGGCCGACATCCTGGCCTACGCGATCGAACCGGTCGCCGAACCC
GCCGCCGACGGCAGGCCGCTGGCCGCCACCGCCTGA

Upstream 100 bases:

>100_bases
GCCTGGGATTCGCCCTCGGCGAACGCCGGATCGGCGCGGAACAAACACGGTAACCCCCGGGTTGAGTAGGTATCGCTCAA
CTTTTGGAAGGGTCGAAGAC

Downstream 100 bases:

>100_bases
CGGCGCACGCGAAGGCCGGGCACGAACCCTCGTGCCCGGCCTTTCGCCTACTCACCCGAGGGCGCGGTCCACCGCTCGGG
TGGTGCCCTGCGCGACGGCG

Product: putative ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 811; Mature: 810

Protein sequence:

>811_residues
MTTPRDLPVLFLTDPIVLPGMVVPIELDESAQAAIDAARAAGTDAVLLAPRLAEGYASYGVIATIEQVGRMRGGAPAAVL
KAERRAKIGHGVTGPGAALWVEAEPVETPPADGRTKELAAEYKKLVVSVLQRREAWQLVDAVNQLTDASAIADTAGYAPY
LTAEQKRELLETPDVAQRLTVLIEWTKAYIAEAEVTEKISDEVRESMEKSQREFLLRQQLNAIRKELGEDEPDGADDYRT
RVEQADLPEAVREAALREVGRLERASDQSPESGWIRTWLDTVLELPWQVKTTDSTDISAARAVLDADHHGLDEVKDRMVE
YLAVRARRAQRGLEVVGGRGSGAVLVLVGPPGVGKTSLGESVARALGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIV
RAMKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVLFIATANVMDTIPGPLLDRME
LITVDGYTEADKVAIARDFLVPRQLERNALTAEEVRITEAALREIAANYTREAGVRQMERLIAKALRKAATRLTESASDP
ADSDSTVTPIRTGYDPELGYDEVVTDRGQTPLTIDVGDLKEYLGRPRFTPDSVERTAVPGVATGLAVTGAGGDVLYIEAN
AAEGERSLTLTGQLGDVMKESAQIALTYVRSHLAEIGIEPSVLDRNIHIHFPAGAVPKDGPSAGVTMVTALVSLALGRQV
RADVGMTGEVTLNGRVLPIGGVKQKLLAAQRAGLKTVFIPARNEPDLDEVPAEVLAALDVRPVADVADILAYAIEPVAEP
AADGRPLAATA

Sequences:

>Translated_811_residues
MTTPRDLPVLFLTDPIVLPGMVVPIELDESAQAAIDAARAAGTDAVLLAPRLAEGYASYGVIATIEQVGRMRGGAPAAVL
KAERRAKIGHGVTGPGAALWVEAEPVETPPADGRTKELAAEYKKLVVSVLQRREAWQLVDAVNQLTDASAIADTAGYAPY
LTAEQKRELLETPDVAQRLTVLIEWTKAYIAEAEVTEKISDEVRESMEKSQREFLLRQQLNAIRKELGEDEPDGADDYRT
RVEQADLPEAVREAALREVGRLERASDQSPESGWIRTWLDTVLELPWQVKTTDSTDISAARAVLDADHHGLDEVKDRMVE
YLAVRARRAQRGLEVVGGRGSGAVLVLVGPPGVGKTSLGESVARALGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIV
RAMKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVLFIATANVMDTIPGPLLDRME
LITVDGYTEADKVAIARDFLVPRQLERNALTAEEVRITEAALREIAANYTREAGVRQMERLIAKALRKAATRLTESASDP
ADSDSTVTPIRTGYDPELGYDEVVTDRGQTPLTIDVGDLKEYLGRPRFTPDSVERTAVPGVATGLAVTGAGGDVLYIEAN
AAEGERSLTLTGQLGDVMKESAQIALTYVRSHLAEIGIEPSVLDRNIHIHFPAGAVPKDGPSAGVTMVTALVSLALGRQV
RADVGMTGEVTLNGRVLPIGGVKQKLLAAQRAGLKTVFIPARNEPDLDEVPAEVLAALDVRPVADVADILAYAIEPVAEP
AADGRPLAATA
>Mature_810_residues
TTPRDLPVLFLTDPIVLPGMVVPIELDESAQAAIDAARAAGTDAVLLAPRLAEGYASYGVIATIEQVGRMRGGAPAAVLK
AERRAKIGHGVTGPGAALWVEAEPVETPPADGRTKELAAEYKKLVVSVLQRREAWQLVDAVNQLTDASAIADTAGYAPYL
TAEQKRELLETPDVAQRLTVLIEWTKAYIAEAEVTEKISDEVRESMEKSQREFLLRQQLNAIRKELGEDEPDGADDYRTR
VEQADLPEAVREAALREVGRLERASDQSPESGWIRTWLDTVLELPWQVKTTDSTDISAARAVLDADHHGLDEVKDRMVEY
LAVRARRAQRGLEVVGGRGSGAVLVLVGPPGVGKTSLGESVARALGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVR
AMKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVLFIATANVMDTIPGPLLDRMEL
ITVDGYTEADKVAIARDFLVPRQLERNALTAEEVRITEAALREIAANYTREAGVRQMERLIAKALRKAATRLTESASDPA
DSDSTVTPIRTGYDPELGYDEVVTDRGQTPLTIDVGDLKEYLGRPRFTPDSVERTAVPGVATGLAVTGAGGDVLYIEANA
AEGERSLTLTGQLGDVMKESAQIALTYVRSHLAEIGIEPSVLDRNIHIHFPAGAVPKDGPSAGVTMVTALVSLALGRQVR
ADVGMTGEVTLNGRVLPIGGVKQKLLAAQRAGLKTVFIPARNEPDLDEVPAEVLAALDVRPVADVADILAYAIEPVAEPA
ADGRPLAATA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=579, Percent_Identity=47.3229706390328, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI21396489, Length=723, Percent_Identity=37.7593360995851, Blast_Score=486, Evalue=1e-137,
Organism=Escherichia coli, GI1786643, Length=811, Percent_Identity=42.2934648581998, Blast_Score=603, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17505831, Length=726, Percent_Identity=37.603305785124, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17556486, Length=821, Percent_Identity=33.0085261875761, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=38.1742738589212, Blast_Score=485, Evalue=1e-138,
Organism=Drosophila melanogaster, GI221513036, Length=758, Percent_Identity=37.598944591029, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=760, Percent_Identity=37.6315789473684, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87187; Mature: 87056

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPRDLPVLFLTDPIVLPGMVVPIELDESAQAAIDAARAAGTDAVLLAPRLAEGYASYG
CCCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHCC
VIATIEQVGRMRGGAPAAVLKAERRAKIGHGVTGPGAALWVEAEPVETPPADGRTKELAA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
EYKKLVVSVLQRREAWQLVDAVNQLTDASAIADTAGYAPYLTAEQKRELLETPDVAQRLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHH
VLIEWTKAYIAEAEVTEKISDEVRESMEKSQREFLLRQQLNAIRKELGEDEPDGADDYRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RVEQADLPEAVREAALREVGRLERASDQSPESGWIRTWLDTVLELPWQVKTTDSTDISAA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHH
RAVLDADHHGLDEVKDRMVEYLAVRARRAQRGLEVVGGRGSGAVLVLVGPPGVGKTSLGE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCCCHHHHH
SVARALGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAMKEAGSMNPVVLLDEIDK
HHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCHHHHHHHHHHHCCCCCEEEEECHHH
VGSDFRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVLFIATANVMDTIPGPLLDRME
HCCCCCCCHHHHHHHHHCCCCCCCCHHHEEEECCCHHHHHHHHHHHHHHHCCCHHHCCEE
LITVDGYTEADKVAIARDFLVPRQLERNALTAEEVRITEAALREIAANYTREAGVRQMER
EEEECCCCCHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIAKALRKAATRLTESASDPADSDSTVTPIRTGYDPELGYDEVVTDRGQTPLTIDVGDLK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEHHHHH
EYLGRPRFTPDSVERTAVPGVATGLAVTGAGGDVLYIEANAAEGERSLTLTGQLGDVMKE
HHHCCCCCCCCCCHHHCCCCHHHCEEEECCCCCEEEEEECCCCCCCEEEEECHHHHHHHH
SAQIALTYVRSHLAEIGIEPSVLDRNIHIHFPAGAVPKDGPSAGVTMVTALVSLALGRQV
HHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHH
RADVGMTGEVTLNGRVLPIGGVKQKLLAAQRAGLKTVFIPARNEPDLDEVPAEVLAALDV
HHCCCCCEEEEECCEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCC
RPVADVADILAYAIEPVAEPAADGRPLAATA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPRDLPVLFLTDPIVLPGMVVPIELDESAQAAIDAARAAGTDAVLLAPRLAEGYASYG
CCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHCC
VIATIEQVGRMRGGAPAAVLKAERRAKIGHGVTGPGAALWVEAEPVETPPADGRTKELAA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
EYKKLVVSVLQRREAWQLVDAVNQLTDASAIADTAGYAPYLTAEQKRELLETPDVAQRLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHH
VLIEWTKAYIAEAEVTEKISDEVRESMEKSQREFLLRQQLNAIRKELGEDEPDGADDYRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RVEQADLPEAVREAALREVGRLERASDQSPESGWIRTWLDTVLELPWQVKTTDSTDISAA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHH
RAVLDADHHGLDEVKDRMVEYLAVRARRAQRGLEVVGGRGSGAVLVLVGPPGVGKTSLGE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCCCHHHHH
SVARALGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAMKEAGSMNPVVLLDEIDK
HHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCHHHHHHHHHHHCCCCCEEEEECHHH
VGSDFRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVLFIATANVMDTIPGPLLDRME
HCCCCCCCHHHHHHHHHCCCCCCCCHHHEEEECCCHHHHHHHHHHHHHHHCCCHHHCCEE
LITVDGYTEADKVAIARDFLVPRQLERNALTAEEVRITEAALREIAANYTREAGVRQMER
EEEECCCCCHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIAKALRKAATRLTESASDPADSDSTVTPIRTGYDPELGYDEVVTDRGQTPLTIDVGDLK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEHHHHH
EYLGRPRFTPDSVERTAVPGVATGLAVTGAGGDVLYIEANAAEGERSLTLTGQLGDVMKE
HHHCCCCCCCCCCHHHCCCCHHHCEEEECCCCCEEEEEECCCCCCCEEEEECHHHHHHHH
SAQIALTYVRSHLAEIGIEPSVLDRNIHIHFPAGAVPKDGPSAGVTMVTALVSLALGRQV
HHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHH
RADVGMTGEVTLNGRVLPIGGVKQKLLAAQRAGLKTVFIPARNEPDLDEVPAEVLAALDV
HHCCCCCEEEEECCEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCC
RPVADVADILAYAIEPVAEPAADGRPLAATA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9425059 [H]