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The map label for this gene is iniA [H]

Identifier: 54027385

GI number: 54027385

Start: 5717146

End: 5719056

Strand: Reverse

Name: iniA [H]

Synonym: nfa54110

Alternate gene names: 54027385

Gene position: 5719056-5717146 (Counterclockwise)

Preceding gene: 54027393

Following gene: 54027384

Centisome position: 94.98

GC content: 72.27

Gene sequence:

>1911_bases
ATGGTGACACCAGCACAGACTCCGGCCGTACCGCTGCTGTCGGTACTGGGTGAAACCATCGCCGTGGCACGCGCCGCGGG
TCGCACCGACCTGGTGGGCCGCCTGGAGGCGGCGGCCGCCCGGGTCCGCGACCCGCGGCGGCGCATCGTGGTGGCGGGCC
TGCTCGGCCAGGGCAAGAGTCGTTTGGTCAACGCGCTGATGAACGCCGAGATCTGCCCGGTCGGCGACGACACCACGACC
ACTGTCGCGACCGTCCTCGCCCACGGTCCGCAGGCGAAAGCCGAACTGGTGCTGACCGATCCGCGCGGCGGCGGCCCGGA
GACGCGGGTGGCGGTTCCGCTCGACCAGCTGGCCGCCGTGGACGAGCGCACGCCGCTCGCCGAGGGCCGCCGCGTGCTGC
GGCTGGAGATCGAACTGCCGAATCCCCTGCTCGCCGACGGCATCGTGCTGGTGGACACCCCTGGCGTCGGTGGTCAGGCG
AGCGCGGGCGCGGCGACCGTGCTGAGCATGGTGCCCGCCGCGGACGCCGTGCTGGTGGTGTCGGACGCCTCCACCGAGCT
GACCGAGCCCGAGCTGGGCTTCCTGCGTCAGGTGCGCGAGCTGTGCCCGACGGTCGCGCTGATGCTCACCAAGACCGACC
TGTACCCGCACTGGCGTCAGGTGCACCACGCGGATCTGGGTCATCTGGAGCGGGCCGGGCTGTCGGTGCCGATCCTCCCG
GTCTCCGCGCTGCTGCGCGCACATGCCATGCGCACCAAGGACGCCCAGCTCGGCCTGGAATCCGGCTACGGCGAGCTGTT
CCGTTTCCTGCGCGAGCAGGTGGTGGCGCGCGATCAGGCCGCGGTCCGCGAGGCGGTGGCCCGCGACATCCACGCCGCCG
CCGAACATCTCGCGCTCGCGCTGGGCAGCGAGCTGCTCGCCCTGCGCGATCCCGATCAGGGCGCGACGGCGATCCGGGAA
CTCCAGTCGGCCAAGACGGCGGCCGAGGACCTGCACCGCCGCACGGCCGCCTGGCAGCAGACGCTGGCCGACGGCATCAC
CGACCTGGCCGGCGACGTCGACCACGATCTGCGGGATCGGCTGCGCGGGATCACCCGGGAAGGGGAGGAGTGGATCGACG
ACCACGACCCCGGCAGGCACTGGGACCGCATCGCCGAGTGGCTGACCATGACCGTGGACAGCGCGCTCGGCGACAACCTG
CTGTGGACGCACAAGCGGGCGGTGGAGCTGGCCGAGCGGGTGGCCGAGCACTTCTCGCACGTCGGTGCGGTCGAATTGCC
GGACGTGCGTGCCGGTTTGGACGGGGAGAGCCGCGCACCGGTCGCCACCCTCGGCGAGCTGGAACCCGACATCGGCCTGG
GCAGCAAGCTGCTGGTGGGCATGCGCGGCTCCTACGGTGGCGTGCTGATGGTCGGCCTGGCCAGTACGTTCGCCGGTTTG
GCCATGTTCAACCCGCTCTCGCTCGGCGCCGGTGTCCTGGTGGGCGGCAAGGCGTTCCGCGACGACAAGCAGGCGCGCCT
GGCCCGCCGCCGCGCCGAGGCCAAGACCGCGATCCGCCGCTTCGTCGACGACGTGGCCTTCCACGCGGGCAAGGAGTCCA
AGGACCGCCTGCACCGCATCCACCGGGCGTTGCGCGACCACTACAGCGGGGTCGCCGAACGCAGCCTGCGCTCGATCGAC
GACTCGCTGCGCGCCGCCCAGGAGGCCGCCACCATGGCCACCGCCCGGCGCACCGAACGCTGTGAGGTGCTCGAACGGCA
ACTGCGCGTGGTCGCCCAGCTGCGCCGCTACGCCGAACAGCTGACCACCGAGCAGAAGACCACCGAGCAGAAGACCACCG
AGCAGAAGAACACGAGCACCGCCGGGACAGCGCCCGCCGCCGTGGAGGGCGCCGGTACGGTTGCCGGGTGA

Upstream 100 bases:

>100_bases
TCGGGCGCCGAGGCCGCCGGGTCGACCGACCTGACCGGCGACGGATTCCTGAACTGATTTCCCGGCACGAGCAACAGAAT
CAGCGAGGTCGACACGCGCG

Downstream 100 bases:

>100_bases
GAACCGACACACCGATGGCGCCGGGAATCGTCGGCGAGGCACATCGCCTGATCGGCGCCGCCCGGCAGTCCTTCGCCGAT
CAGCCGCGCCCGCGCGCCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MVTPAQTPAVPLLSVLGETIAVARAAGRTDLVGRLEAAAARVRDPRRRIVVAGLLGQGKSRLVNALMNAEICPVGDDTTT
TVATVLAHGPQAKAELVLTDPRGGGPETRVAVPLDQLAAVDERTPLAEGRRVLRLEIELPNPLLADGIVLVDTPGVGGQA
SAGAATVLSMVPAADAVLVVSDASTELTEPELGFLRQVRELCPTVALMLTKTDLYPHWRQVHHADLGHLERAGLSVPILP
VSALLRAHAMRTKDAQLGLESGYGELFRFLREQVVARDQAAVREAVARDIHAAAEHLALALGSELLALRDPDQGATAIRE
LQSAKTAAEDLHRRTAAWQQTLADGITDLAGDVDHDLRDRLRGITREGEEWIDDHDPGRHWDRIAEWLTMTVDSALGDNL
LWTHKRAVELAERVAEHFSHVGAVELPDVRAGLDGESRAPVATLGELEPDIGLGSKLLVGMRGSYGGVLMVGLASTFAGL
AMFNPLSLGAGVLVGGKAFRDDKQARLARRRAEAKTAIRRFVDDVAFHAGKESKDRLHRIHRALRDHYSGVAERSLRSID
DSLRAAQEAATMATARRTERCEVLERQLRVVAQLRRYAEQLTTEQKTTEQKTTEQKNTSTAGTAPAAVEGAGTVAG

Sequences:

>Translated_636_residues
MVTPAQTPAVPLLSVLGETIAVARAAGRTDLVGRLEAAAARVRDPRRRIVVAGLLGQGKSRLVNALMNAEICPVGDDTTT
TVATVLAHGPQAKAELVLTDPRGGGPETRVAVPLDQLAAVDERTPLAEGRRVLRLEIELPNPLLADGIVLVDTPGVGGQA
SAGAATVLSMVPAADAVLVVSDASTELTEPELGFLRQVRELCPTVALMLTKTDLYPHWRQVHHADLGHLERAGLSVPILP
VSALLRAHAMRTKDAQLGLESGYGELFRFLREQVVARDQAAVREAVARDIHAAAEHLALALGSELLALRDPDQGATAIRE
LQSAKTAAEDLHRRTAAWQQTLADGITDLAGDVDHDLRDRLRGITREGEEWIDDHDPGRHWDRIAEWLTMTVDSALGDNL
LWTHKRAVELAERVAEHFSHVGAVELPDVRAGLDGESRAPVATLGELEPDIGLGSKLLVGMRGSYGGVLMVGLASTFAGL
AMFNPLSLGAGVLVGGKAFRDDKQARLARRRAEAKTAIRRFVDDVAFHAGKESKDRLHRIHRALRDHYSGVAERSLRSID
DSLRAAQEAATMATARRTERCEVLERQLRVVAQLRRYAEQLTTEQKTTEQKTTEQKNTSTAGTAPAAVEGAGTVAG
>Mature_636_residues
MVTPAQTPAVPLLSVLGETIAVARAAGRTDLVGRLEAAAARVRDPRRRIVVAGLLGQGKSRLVNALMNAEICPVGDDTTT
TVATVLAHGPQAKAELVLTDPRGGGPETRVAVPLDQLAAVDERTPLAEGRRVLRLEIELPNPLLADGIVLVDTPGVGGQA
SAGAATVLSMVPAADAVLVVSDASTELTEPELGFLRQVRELCPTVALMLTKTDLYPHWRQVHHADLGHLERAGLSVPILP
VSALLRAHAMRTKDAQLGLESGYGELFRFLREQVVARDQAAVREAVARDIHAAAEHLALALGSELLALRDPDQGATAIRE
LQSAKTAAEDLHRRTAAWQQTLADGITDLAGDVDHDLRDRLRGITREGEEWIDDHDPGRHWDRIAEWLTMTVDSALGDNL
LWTHKRAVELAERVAEHFSHVGAVELPDVRAGLDGESRAPVATLGELEPDIGLGSKLLVGMRGSYGGVLMVGLASTFAGL
AMFNPLSLGAGVLVGGKAFRDDKQARLARRRAEAKTAIRRFVDDVAFHAGKESKDRLHRIHRALRDHYSGVAERSLRSID
DSLRAAQEAATMATARRTERCEVLERQLRVVAQLRRYAEQLTTEQKTTEQKTTEQKNTSTAGTAPAAVEGAGTVAG

Specific function: Participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell [H]

COG id: COG0699

COG function: function code R; Predicted GTPases (dynamin-related)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001401 [H]

Pfam domain/function: PF00350 Dynamin_N [H]

EC number: NA

Molecular weight: Translated: 68330; Mature: 68330

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPAQTPAVPLLSVLGETIAVARAAGRTDLVGRLEAAAARVRDPRRRIVVAGLLGQGKS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHEEEEEHHCCCHH
RLVNALMNAEICPVGDDTTTTVATVLAHGPQAKAELVLTDPRGGGPETRVAVPLDQLAAV
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCHHHHHHH
DERTPLAEGRRVLRLEIELPNPLLADGIVLVDTPGVGGQASAGAATVLSMVPAADAVLVV
HCCCCHHHCCEEEEEEEECCCCHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEE
SDASTELTEPELGFLRQVRELCPTVALMLTKTDLYPHWRQVHHADLGHLERAGLSVPILP
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
VSALLRAHAMRTKDAQLGLESGYGELFRFLREQVVARDQAAVREAVARDIHAAAEHLALA
HHHHHHHHHHCCCHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGSELLALRDPDQGATAIRELQSAKTAAEDLHRRTAAWQQTLADGITDLAGDVDHDLRDR
HCCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LRGITREGEEWIDDHDPGRHWDRIAEWLTMTVDSALGDNLLWTHKRAVELAERVAEHFSH
HHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VGAVELPDVRAGLDGESRAPVATLGELEPDIGLGSKLLVGMRGSYGGVLMVGLASTFAGL
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHH
AMFNPLSLGAGVLVGGKAFRDDKQARLARRRAEAKTAIRRFVDDVAFHAGKESKDRLHRI
HHCCHHHHCCCEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
HRALRDHYSGVAERSLRSIDDSLRAAQEAATMATARRTERCEVLERQLRVVAQLRRYAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTTEQKTTEQKTTEQKNTSTAGTAPAAVEGAGTVAG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVTPAQTPAVPLLSVLGETIAVARAAGRTDLVGRLEAAAARVRDPRRRIVVAGLLGQGKS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHEEEEEHHCCCHH
RLVNALMNAEICPVGDDTTTTVATVLAHGPQAKAELVLTDPRGGGPETRVAVPLDQLAAV
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCHHHHHHH
DERTPLAEGRRVLRLEIELPNPLLADGIVLVDTPGVGGQASAGAATVLSMVPAADAVLVV
HCCCCHHHCCEEEEEEEECCCCHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEE
SDASTELTEPELGFLRQVRELCPTVALMLTKTDLYPHWRQVHHADLGHLERAGLSVPILP
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
VSALLRAHAMRTKDAQLGLESGYGELFRFLREQVVARDQAAVREAVARDIHAAAEHLALA
HHHHHHHHHHCCCHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGSELLALRDPDQGATAIRELQSAKTAAEDLHRRTAAWQQTLADGITDLAGDVDHDLRDR
HCCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LRGITREGEEWIDDHDPGRHWDRIAEWLTMTVDSALGDNLLWTHKRAVELAERVAEHFSH
HHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VGAVELPDVRAGLDGESRAPVATLGELEPDIGLGSKLLVGMRGSYGGVLMVGLASTFAGL
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHH
AMFNPLSLGAGVLVGGKAFRDDKQARLARRRAEAKTAIRRFVDDVAFHAGKESKDRLHRI
HHCCHHHHCCCEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
HRALRDHYSGVAERSLRSIDDSLRAAQEAATMATARRTERCEVLERQLRVVAQLRRYAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTTEQKTTEQKTTEQKNTSTAGTAPAAVEGAGTVAG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]