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The map label for this gene is hbhA [H]

Identifier: 54027182

GI number: 54027182

Start: 5503037

End: 5503702

Strand: Reverse

Name: hbhA [H]

Synonym: nfa52080

Alternate gene names: 54027182

Gene position: 5503702-5503037 (Counterclockwise)

Preceding gene: 54027183

Following gene: 54027181

Centisome position: 91.41

GC content: 72.52

Gene sequence:

>666_bases
ATGACCGAGAAGACCGCCACCGTCACCAAGCCTCTGCTCGCCGCGGTCGGCGCCGGGGACGCCGTTTACACGGCGGCCCT
CGACGTCGTCACCCAGGTGCGCGAGAAGGCCACCACCACCGACGTCTCCGGCCGGGTCGAGGAGGCGCGCGAGCGCTTCG
CCCACGTGCCCGCCGATGTGCAGGCCCAGTTCGAGTCGCTGCGCGAGCGGCTGGCCGGCCTGCCCACCGAGCTGCCGGAC
GAGCTCGCCGAGCTGCGCGAGAAGTTCACCGCCGAGGAACTGCGCAAGCTGGCCGAGGAGTACTACGCCAAGGTGCTCGA
CCTCTACTCCGACCTCGCCGTGCGCGGTGAGGAGACCGTGGAGCGGCTGCGTGCCAACCACCTGGTCGAGGATCAGATCG
AGCGCGTGGAGAGCCTCTACAAGGACGCCGCCTCGCGCGCCGAGGAGGTCGTCGGCCGGGTGAACGGCCTGCTGGGCCGT
CCGGCCAAGGCGGAGGAGAGCGCTCCCGAGGCCACCGCCACCGCGGCGCCCGTCGTCGACGCCGAGGTCGTCGAGGTGAC
CACCGAGACCACCCCCGCCCCGGCCAAGAAGGCCGCCCCCGCCGCGAAGAAGGCGCCGGCCAAGAAGGCCGCCCCGGCGA
AGAAGGCCGCCCCGAAGAACGTCTGA

Upstream 100 bases:

>100_bases
GGCAGAAGCAGGTGCTGCTGGACATCTACGAATCGTTCCGTCGAGAAAACGGCGAGAACGAGACAACCGACACTCCGCCA
CGCCAGGAGAGCGAACAACC

Downstream 100 bases:

>100_bases
TCGCGTCCGGGAGCCCGGACCGGGTTTTCCGACCGCCCTCGCGCACGCTGCTGCGCGGGGGCGGTTTTCGTATCATGGGG
GAGTGCAAACGGTGAACGGG

Product: putative heparin-binding hemagglutinin

Products: NA

Alternate protein names: Adhesin [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTEKTATVTKPLLAAVGAGDAVYTAALDVVTQVREKATTTDVSGRVEEARERFAHVPADVQAQFESLRERLAGLPTELPD
ELAELREKFTAEELRKLAEEYYAKVLDLYSDLAVRGEETVERLRANHLVEDQIERVESLYKDAASRAEEVVGRVNGLLGR
PAKAEESAPEATATAAPVVDAEVVEVTTETTPAPAKKAAPAAKKAPAKKAAPAKKAAPKNV

Sequences:

>Translated_221_residues
MTEKTATVTKPLLAAVGAGDAVYTAALDVVTQVREKATTTDVSGRVEEARERFAHVPADVQAQFESLRERLAGLPTELPD
ELAELREKFTAEELRKLAEEYYAKVLDLYSDLAVRGEETVERLRANHLVEDQIERVESLYKDAASRAEEVVGRVNGLLGR
PAKAEESAPEATATAAPVVDAEVVEVTTETTPAPAKKAAPAAKKAPAKKAAPAKKAAPKNV
>Mature_220_residues
TEKTATVTKPLLAAVGAGDAVYTAALDVVTQVREKATTTDVSGRVEEARERFAHVPADVQAQFESLRERLAGLPTELPDE
LAELREKFTAEELRKLAEEYYAKVLDLYSDLAVRGEETVERLRANHLVEDQIERVESLYKDAASRAEEVVGRVNGLLGRP
AKAEESAPEATATAAPVVDAEVVEVTTETTPAPAKKAAPAAKKAPAKKAAPAKKAAPKNV

Specific function: Required for extrapulmonary dissemination. Mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. Promotes hemagglutination of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell surface [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.leprae hbhA [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020340
- ProDom:   PD082580 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 23713; Mature: 23582

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKTATVTKPLLAAVGAGDAVYTAALDVVTQVREKATTTDVSGRVEEARERFAHVPADV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QAQFESLRERLAGLPTELPDELAELREKFTAEELRKLAEEYYAKVLDLYSDLAVRGEETV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ERLRANHLVEDQIERVESLYKDAASRAEEVVGRVNGLLGRPAKAEESAPEATATAAPVVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHH
AEVVEVTTETTPAPAKKAAPAAKKAPAKKAAPAKKAAPKNV
HHHHHHHCCCCCCCHHHCCCCHHHCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
TEKTATVTKPLLAAVGAGDAVYTAALDVVTQVREKATTTDVSGRVEEARERFAHVPADV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QAQFESLRERLAGLPTELPDELAELREKFTAEELRKLAEEYYAKVLDLYSDLAVRGEETV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ERLRANHLVEDQIERVESLYKDAASRAEEVVGRVNGLLGRPAKAEESAPEATATAAPVVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHH
AEVVEVTTETTPAPAKKAAPAAKKAPAKKAAPAKKAAPKNV
HHHHHHHCCCCCCCHHHCCCCHHHCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972; 11449276 [H]