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The map label for this gene is murB

Identifier: 54027171

GI number: 54027171

Start: 5494794

End: 5495942

Strand: Reverse

Name: murB

Synonym: nfa51970

Alternate gene names: 54027171

Gene position: 5495942-5494794 (Counterclockwise)

Preceding gene: 54027175

Following gene: 54027170

Centisome position: 91.28

GC content: 74.33

Gene sequence:

>1149_bases
ATGACTGGACACGCTACCGTCTGGGGCGTGCGAATTTCACGGGTGGTGCCGGGCCGCGCGGTGACCGGCGACGAGGTGCG
CGAGCTGCTCTCCGGCACCGGCGCGACGGTCCGCGAGGCGGTGCGATTGGCGGAGCTGACCACGTTGCGCGTCGGCGGCC
CCGCCGTGCTCGCCGAATGCGGTACCACCGAAGCCCTGGTGGCGACCGTGCGCGCGCTCGACGCCGCCGGTGTGCCGGTG
TTGCTGCTCGCGGGCGGCTCGAATCTGCTGGTCGGTGACGACGGTTTCGACGGCGTCGTGGTGCGGGTCGCGACCAGCGG
GGTGGAGCTCGGCGCCGACGGCGTGCTCGCCGAGGCGGGCGCCGACTGGGACGCGGTGGTGGCCGCCACCGTCGCGGCGG
GTCTCGGCGGGCTGGAATGCCTGTCCGGCATTCCCGGTTCCGCGGGTGCGACGCCGGTGCAGAACGTCGGCGCCTACGGC
GTGGAGGTCGCCGAGCTGTTGCGCCGGGTGCGGCTGCTGGACCGGGCCACCGGCGAGATCCGCTGGGCCGGTCCCGGTGA
ACTCGGCTTCGGCTACCGCACCAGCGTGCTCAAGCACAGCGACGCGGCCGTGGTGCTCGCCGTCGAGTTCGCGCTGCGCC
CGGACGGCAGCAGCGCGCCGCTGCGCTACCGGGAGCTGGCCGCGGCGCTGGCGGCGGACGAGGGCGAGTCGCGGCCCGCG
GCCGCCGTGCGCGAGGCCGTGCTGCGGTTGCGCGCGAGCAAAGGGATGGTGCTCGATCCGGCCGACCACGACACGTGGAG
CGCGGGCTCGTTCTTCACCAACCCGGTGGTGCCCGCCGACCGGATCGAGCAGGTACGCGCCGCGATCCACGCCCATGTGG
GTGAGGTCACGATTCCCACCTATCCGGCCGCGGACGGTGTCAAGCTCTCGGCGGGCTGGCTGATCGAGCGCGCCGGCTTC
GGCAAGGGCTGGCCGGGTGCGGAGGCGCCCGCCCGGCTGTCCACGAAACACACACTGGCGCTGACCAATCGGGGTACCGC
CCGGGCCGCCGACGTGGTCGCGCTGGCCCGCACCGTGCGCGACGGTGTCGCCGAGCGCTTCGGCATCCGGCTCGAACCCG
AACCGGTCACCGTCGGCGTGCGGCTGTAG

Upstream 100 bases:

>100_bases
CTCGGCGATACGGTCCTTCCAGTACTGCTCGTCGGAGAAGGCCGCGCGCACGGCGGAGACGGGATGGGTGTAGCGGGCCG
TGAACGCCAAGGGTGTCGCC

Downstream 100 bases:

>100_bases
ACGGCGCGCCACCCGAACCCGGCGGGGCGCGCCGCGCGTGCGGCCGCGCGGCCCGCCCCGCGCGTAGATTCGACAGACGT
GAGCTACCGCCCGTTGACCC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTGHATVWGVRISRVVPGRAVTGDEVRELLSGTGATVREAVRLAELTTLRVGGPAVLAECGTTEALVATVRALDAAGVPV
LLLAGGSNLLVGDDGFDGVVVRVATSGVELGADGVLAEAGADWDAVVAATVAAGLGGLECLSGIPGSAGATPVQNVGAYG
VEVAELLRRVRLLDRATGEIRWAGPGELGFGYRTSVLKHSDAAVVLAVEFALRPDGSSAPLRYRELAAALAADEGESRPA
AAVREAVLRLRASKGMVLDPADHDTWSAGSFFTNPVVPADRIEQVRAAIHAHVGEVTIPTYPAADGVKLSAGWLIERAGF
GKGWPGAEAPARLSTKHTLALTNRGTARAADVVALARTVRDGVAERFGIRLEPEPVTVGVRL

Sequences:

>Translated_382_residues
MTGHATVWGVRISRVVPGRAVTGDEVRELLSGTGATVREAVRLAELTTLRVGGPAVLAECGTTEALVATVRALDAAGVPV
LLLAGGSNLLVGDDGFDGVVVRVATSGVELGADGVLAEAGADWDAVVAATVAAGLGGLECLSGIPGSAGATPVQNVGAYG
VEVAELLRRVRLLDRATGEIRWAGPGELGFGYRTSVLKHSDAAVVLAVEFALRPDGSSAPLRYRELAAALAADEGESRPA
AAVREAVLRLRASKGMVLDPADHDTWSAGSFFTNPVVPADRIEQVRAAIHAHVGEVTIPTYPAADGVKLSAGWLIERAGF
GKGWPGAEAPARLSTKHTLALTNRGTARAADVVALARTVRDGVAERFGIRLEPEPVTVGVRL
>Mature_381_residues
TGHATVWGVRISRVVPGRAVTGDEVRELLSGTGATVREAVRLAELTTLRVGGPAVLAECGTTEALVATVRALDAAGVPVL
LLAGGSNLLVGDDGFDGVVVRVATSGVELGADGVLAEAGADWDAVVAATVAAGLGGLECLSGIPGSAGATPVQNVGAYGV
EVAELLRRVRLLDRATGEIRWAGPGELGFGYRTSVLKHSDAAVVLAVEFALRPDGSSAPLRYRELAAALAADEGESRPAA
AVREAVLRLRASKGMVLDPADHDTWSAGSFFTNPVVPADRIEQVRAAIHAHVGEVTIPTYPAADGVKLSAGWLIERAGFG
KGWPGAEAPARLSTKHTLALTNRGTARAADVVALARTVRDGVAERFGIRLEPEPVTVGVRL

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=323, Percent_Identity=35.6037151702786, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_NOCFA (Q5YP42)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_121413.1
- ProteinModelPortal:   Q5YP42
- GeneID:   3111304
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa51970
- NMPDR:   fig|247156.1.peg.4994
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK13903
- BioCyc:   NFAR247156:NFA51970-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 39221; Mature: 39090

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 193-193 ACT_SITE 270-270 ACT_SITE 374-374

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGHATVWGVRISRVVPGRAVTGDEVRELLSGTGATVREAVRLAELTTLRVGGPAVLAEC
CCCCEEEEEEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCEEEEEC
GTTEALVATVRALDAAGVPVLLLAGGSNLLVGDDGFDGVVVRVATSGVELGADGVLAEAG
CCHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCEEEEEEECCCEECCCCEEECCC
ADWDAVVAATVAAGLGGLECLSGIPGSAGATPVQNVGAYGVEVAELLRRVRLLDRATGEI
CCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCE
RWAGPGELGFGYRTSVLKHSDAAVVLAVEFALRPDGSSAPLRYRELAAALAADEGESRPA
EECCCCCCCCCHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHH
AAVREAVLRLRASKGMVLDPADHDTWSAGSFFTNPVVPADRIEQVRAAIHAHVGEVTIPT
HHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECC
YPAADGVKLSAGWLIERAGFGKGWPGAEAPARLSTKHTLALTNRGTARAADVVALARTVR
CCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
DGVAERFGIRLEPEPVTVGVRL
HHHHHHHCCEECCCCEEEEEEC
>Mature Secondary Structure 
TGHATVWGVRISRVVPGRAVTGDEVRELLSGTGATVREAVRLAELTTLRVGGPAVLAEC
CCCEEEEEEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCEEEEEC
GTTEALVATVRALDAAGVPVLLLAGGSNLLVGDDGFDGVVVRVATSGVELGADGVLAEAG
CCHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCEEEEEEECCCEECCCCEEECCC
ADWDAVVAATVAAGLGGLECLSGIPGSAGATPVQNVGAYGVEVAELLRRVRLLDRATGEI
CCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCE
RWAGPGELGFGYRTSVLKHSDAAVVLAVEFALRPDGSSAPLRYRELAAALAADEGESRPA
EECCCCCCCCCHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHH
AAVREAVLRLRASKGMVLDPADHDTWSAGSFFTNPVVPADRIEQVRAAIHAHVGEVTIPT
HHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECC
YPAADGVKLSAGWLIERAGFGKGWPGAEAPARLSTKHTLALTNRGTARAADVVALARTVR
CCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
DGVAERFGIRLEPEPVTVGVRL
HHHHHHHCCEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA