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The map label for this gene is betA [C]

Identifier: 54027039

GI number: 54027039

Start: 5363667

End: 5365157

Strand: Reverse

Name: betA [C]

Synonym: nfa50650

Alternate gene names: 54027039

Gene position: 5365157-5363667 (Counterclockwise)

Preceding gene: 54027040

Following gene: 54027038

Centisome position: 89.1

GC content: 75.45

Gene sequence:

>1491_bases
GTGACGGACACCCTGATCGTCGGCGGTGGCACCGCCGGTTGCGTGCTCGCCGCCCGGTTGAGCGAGGACCCCGCGCACAC
GGTCCGGGTGCTCGAGGCAGGCCCGGTGTGGCTGGAACCGCAGCGGTGGCCCGCCGCCCTGCGCGACGCCGGCCGCATGC
CCATCGATCCGACCGCGCCGTGGCTGTGGCGCTACACCTCGACCCTGGACGACGGTGCGGGCGCGGCCGCCGCCGTGGTC
GGGCAGCTGGTGCGCGGACGGGTGCTCGGCGGCTCGAGTTCGGTGAACGGCAGCTACTTCGGGCGCGCCCGCGCGGCGGA
CTTCGCGGCCTGGAGCCGGATCGCGGGACCGCTCTGGGACTTCGACGCCGTGCTACCCGCGTACGAGCGCAGCGAACGCG
ACCTGGATTTCGGCGACCGGCCCGGCCACGGCGCGCACGGCCCGATCCCGGTGCGCCGCACCGCGACCGGGGTCCCGGTG
AGCCGTCTGTTCGCCGACGCCGTGCGAGCGGCCGGGTTCGGCGAGCGCGCCGACCTCAACGGCCTCCCCGATGCCGGACC
GTCGACGGGGCTGGCGAAGGTGCCGTGCAATGTCGCCGACGGCCGCCGGGTCGGCACCGCGGCCGCCTACCTGCTGCCCG
CCGCGACGCGACCGAATCTGCGGGTGGACGGTGAGGTTCCGGTCTCGCGCATCCTGTTCCGGCGCGGGCGCGCGGTGGGT
GTCGAGTACCGGCGCGGCCGGGCGGCGGAGACGGCGTGGGCCGATCGGATCGTGCTGTGCGCGGGTGCGGTGGAATCGGC
TGCGCTGCTGCTGCGTTCGGGCATCGGGCCGCCCGGGCAGCTCCGCGCCCTCGGGATCACGCCGGTGCAGGCCGCACCGG
TCGGCAGCTGGTGCACCGACCATCCCGAGATCGGCGTGGAGTACCGGCTGGAACCGGAACCGGATCGGCCGCCGACCGTG
CCGCTGGAATACGTGCTCGACCTGGACGACATCGAAATACGGCCCTACACGGTGTCTTTCACGCCGGACACGTATCGTCT
CGGGGTGGCCCTGATGCGACCGCTGGCCGCGGGCGAGTTGCGGTTGCGGTCGGCCGATCCCGCCCGGCCGCCGGTCCTCG
AACACCGGTACCTGTCCGCGGCGGCCGACCGGGATCGGTTGTGCGCGGCCGCGGTGCTGGCCACCGATCTGCTCGCCGCG
GTGCCCGGCGCCCGGGCGAGTACGGTCGCGCCACCGGCGGCGGGGGAGCGGGCGGCGGCGTGGTTGCGGGCGCGTCTCGC
CACCTCCCAGCACCTGTCGGGCACCTGCCGGATGGGCGGGCCCGAGGACCCCGCGGCGGTGGTCGACGCGCACTGCCGGG
TACACGGGCTGGCCGGGCTGGCCGTGGTCGACCTGTCCATCGTCCCGGTGCCGCTGAGCCGTGGACCGCAGGCCAGCGCC
GTCATGCTCGCCGAGCGCGCCGCCGAGTTCCTGCGCGACGGAGAGTTCTGA

Upstream 100 bases:

>100_bases
TCTCGCCTACGGCACCGGGCTGTGGGTGGGGGCGGCCCGGGCGCGCAGCCTCGACGCGCTGCGGCCGGCCTTCTCGCGGC
GCTGAGGACGGCGGGCGGCG

Downstream 100 bases:

>100_bases
AAGACAAATAGGTCACAATTCGCGAAGGTATGGAGCCGATGTGACCTGTCGGACAAACCGAACATCCACCCCTCGCCGGG
GAAAACGCGCCGGTACAGTT

Product: putative oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTDTLIVGGGTAGCVLAARLSEDPAHTVRVLEAGPVWLEPQRWPAALRDAGRMPIDPTAPWLWRYTSTLDDGAGAAAAVV
GQLVRGRVLGGSSSVNGSYFGRARAADFAAWSRIAGPLWDFDAVLPAYERSERDLDFGDRPGHGAHGPIPVRRTATGVPV
SRLFADAVRAAGFGERADLNGLPDAGPSTGLAKVPCNVADGRRVGTAAAYLLPAATRPNLRVDGEVPVSRILFRRGRAVG
VEYRRGRAAETAWADRIVLCAGAVESAALLLRSGIGPPGQLRALGITPVQAAPVGSWCTDHPEIGVEYRLEPEPDRPPTV
PLEYVLDLDDIEIRPYTVSFTPDTYRLGVALMRPLAAGELRLRSADPARPPVLEHRYLSAAADRDRLCAAAVLATDLLAA
VPGARASTVAPPAAGERAAAWLRARLATSQHLSGTCRMGGPEDPAAVVDAHCRVHGLAGLAVVDLSIVPVPLSRGPQASA
VMLAERAAEFLRDGEF

Sequences:

>Translated_496_residues
MTDTLIVGGGTAGCVLAARLSEDPAHTVRVLEAGPVWLEPQRWPAALRDAGRMPIDPTAPWLWRYTSTLDDGAGAAAAVV
GQLVRGRVLGGSSSVNGSYFGRARAADFAAWSRIAGPLWDFDAVLPAYERSERDLDFGDRPGHGAHGPIPVRRTATGVPV
SRLFADAVRAAGFGERADLNGLPDAGPSTGLAKVPCNVADGRRVGTAAAYLLPAATRPNLRVDGEVPVSRILFRRGRAVG
VEYRRGRAAETAWADRIVLCAGAVESAALLLRSGIGPPGQLRALGITPVQAAPVGSWCTDHPEIGVEYRLEPEPDRPPTV
PLEYVLDLDDIEIRPYTVSFTPDTYRLGVALMRPLAAGELRLRSADPARPPVLEHRYLSAAADRDRLCAAAVLATDLLAA
VPGARASTVAPPAAGERAAAWLRARLATSQHLSGTCRMGGPEDPAAVVDAHCRVHGLAGLAVVDLSIVPVPLSRGPQASA
VMLAERAAEFLRDGEF
>Mature_495_residues
TDTLIVGGGTAGCVLAARLSEDPAHTVRVLEAGPVWLEPQRWPAALRDAGRMPIDPTAPWLWRYTSTLDDGAGAAAAVVG
QLVRGRVLGGSSSVNGSYFGRARAADFAAWSRIAGPLWDFDAVLPAYERSERDLDFGDRPGHGAHGPIPVRRTATGVPVS
RLFADAVRAAGFGERADLNGLPDAGPSTGLAKVPCNVADGRRVGTAAAYLLPAATRPNLRVDGEVPVSRILFRRGRAVGV
EYRRGRAAETAWADRIVLCAGAVESAALLLRSGIGPPGQLRALGITPVQAAPVGSWCTDHPEIGVEYRLEPEPDRPPTVP
LEYVLDLDDIEIRPYTVSFTPDTYRLGVALMRPLAAGELRLRSADPARPPVLEHRYLSAAADRDRLCAAAVLATDLLAAV
PGARASTVAPPAAGERAAAWLRARLATSQHLSGTCRMGGPEDPAAVVDAHCRVHGLAGLAVVDLSIVPVPLSRGPQASAV
MLAERAAEFLRDGEF

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=545, Percent_Identity=32.8440366972477, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1786503, Length=546, Percent_Identity=30.2197802197802, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17532301, Length=554, Percent_Identity=28.3393501805054, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=28.3216783216783, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI45549471, Length=572, Percent_Identity=28.6713286713287, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=29.3906810035842, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=27.5261324041812, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642039, Length=575, Percent_Identity=27.1304347826087, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=28.2456140350877, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642055, Length=313, Percent_Identity=34.8242811501597, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24642035, Length=305, Percent_Identity=34.0983606557377, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24642037, Length=316, Percent_Identity=35.126582278481, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24650267, Length=306, Percent_Identity=31.0457516339869, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24642048, Length=311, Percent_Identity=32.475884244373, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859995, Length=305, Percent_Identity=30.4918032786885, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18859993, Length=332, Percent_Identity=29.8192771084337, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24642051, Length=327, Percent_Identity=31.8042813455657, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 52247; Mature: 52116

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTLIVGGGTAGCVLAARLSEDPAHTVRVLEAGPVWLEPQRWPAALRDAGRMPIDPTAP
CCCEEEECCCCHHHHEEECCCCCCCCEEEEEECCCCEECCCCCCHHHHHCCCCCCCCCCC
WLWRYTSTLDDGAGAAAAVVGQLVRGRVLGGSSSVNGSYFGRARAADFAAWSRIAGPLWD
HHEEECCCCCCCCCHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
FDAVLPAYERSERDLDFGDRPGHGAHGPIPVRRTATGVPVSRLFADAVRAAGFGERADLN
HHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
GLPDAGPSTGLAKVPCNVADGRRVGTAAAYLLPAATRPNLRVDGEVPVSRILFRRGRAVG
CCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCCEEC
VEYRRGRAAETAWADRIVLCAGAVESAALLLRSGIGPPGQLRALGITPVQAAPVGSWCTD
EEHHCCCCHHHHHHCEEEEEECCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCC
HPEIGVEYRLEPEPDRPPTVPLEYVLDLDDIEIRPYTVSFTPDTYRLGVALMRPLAAGEL
CCCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCE
RLRSADPARPPVLEHRYLSAAADRDRLCAAAVLATDLLAAVPGARASTVAPPAAGERAAA
EEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
WLRARLATSQHLSGTCRMGGPEDPAAVVDAHCRVHGLAGLAVVDLSIVPVPLSRGPQASA
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHEECCCCEEEEEEEEEEECCCCCCCHHH
VMLAERAAEFLRDGEF
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDTLIVGGGTAGCVLAARLSEDPAHTVRVLEAGPVWLEPQRWPAALRDAGRMPIDPTAP
CCEEEECCCCHHHHEEECCCCCCCCEEEEEECCCCEECCCCCCHHHHHCCCCCCCCCCC
WLWRYTSTLDDGAGAAAAVVGQLVRGRVLGGSSSVNGSYFGRARAADFAAWSRIAGPLWD
HHEEECCCCCCCCCHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
FDAVLPAYERSERDLDFGDRPGHGAHGPIPVRRTATGVPVSRLFADAVRAAGFGERADLN
HHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
GLPDAGPSTGLAKVPCNVADGRRVGTAAAYLLPAATRPNLRVDGEVPVSRILFRRGRAVG
CCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCCEEC
VEYRRGRAAETAWADRIVLCAGAVESAALLLRSGIGPPGQLRALGITPVQAAPVGSWCTD
EEHHCCCCHHHHHHCEEEEEECCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCC
HPEIGVEYRLEPEPDRPPTVPLEYVLDLDDIEIRPYTVSFTPDTYRLGVALMRPLAAGEL
CCCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCE
RLRSADPARPPVLEHRYLSAAADRDRLCAAAVLATDLLAAVPGARASTVAPPAAGERAAA
EEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
WLRARLATSQHLSGTCRMGGPEDPAAVVDAHCRVHGLAGLAVVDLSIVPVPLSRGPQASA
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHEECCCCEEEEEEEEEEECCCCCCCHHH
VMLAERAAEFLRDGEF
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7836301 [H]