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The map label for this gene is mprA [H]

Identifier: 54026938

GI number: 54026938

Start: 5180449

End: 5181135

Strand: Reverse

Name: mprA [H]

Synonym: nfa49640

Alternate gene names: 54026938

Gene position: 5181135-5180449 (Counterclockwise)

Preceding gene: 54026945

Following gene: 54026937

Centisome position: 86.05

GC content: 67.83

Gene sequence:

>687_bases
ATGCGCATTCTGGTAGTCGACGACGATCGCGCCGTCCGGGAATCGCTGCGCCGGTCGTTGACCTTCAACGGCTACACCGT
GGACCTCGCCGTGGACGGGGTCGACGCACTGGAGAAAGCCACCGCGCAGCGGCCGGACGCGCTCGTGCTGGATGTCATGA
TGCCGCGGCTGGACGGGCTGGAGGTTTGCCGGCGTTTGCGCAGTACCGGTGACGATCTTCCGATTCTGGTTTTGACGGCG
CGGGATTCGGTTTCCGAAAGGGTTGCCGGGCTCGACGCGGGGGCCGACGATTATCTGCCCAAGCCATTCGCGCTGGAAGA
ATTGCTGGCCCGGCTGCGCGCCCTGTTGCGCCGTCGCGCGCCCGATCCGGGTGACACCTCCGAGACGTTGCGCTTCGCCG
ACCTATCGCTGGACCCGGTCACCCGCGAGGTCTCCCGCGGCGACCGCGCGATCAGCCTGACCCGCACCGAGTTCTCCCTG
CTCGAGATGCTGATGGCCAATCCGCGGCGGGTGCTGACCCGTAGCCGCATTCTCGAGGAGGTGTGGGGCTACGACTTCCC
CACCTCGGGTAACGCGCTCGAGGTCTACATCGGCTACCTGCGACGCAAGACCGAGGCCGAGGGCGAGCCGCGGCTGATCC
ACACCGTGCGCGGCGTCGGGTACGTGCTGCGCGAGACCCCGCCGTAG

Upstream 100 bases:

>100_bases
CACCCCGCGTGGCTCGGCGTGTCGCCGGTAGCGGGGACTTCGCGGCGTGTCGCGCGTGGCCTCTCAGTCGCCTCTCAGTC
GATGCGGTCAAACTGGTCGC

Downstream 100 bases:

>100_bases
GCGCGCGATGGCACGAAGCGCGCCCCGGCGGCCCGCCGTCGCCCCGGTCGGCCGGCCGGTCGAACCGCCGCCGATGCGTC
CGCCGATGCCCCTGACCAGT

Product: putative two-component system response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRILVVDDDRAVRESLRRSLTFNGYTVDLAVDGVDALEKATAQRPDALVLDVMMPRLDGLEVCRRLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRRAPDPGDTSETLRFADLSLDPVTREVSRGDRAISLTRTEFSL
LEMLMANPRRVLTRSRILEEVWGYDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP

Sequences:

>Translated_228_residues
MRILVVDDDRAVRESLRRSLTFNGYTVDLAVDGVDALEKATAQRPDALVLDVMMPRLDGLEVCRRLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRRAPDPGDTSETLRFADLSLDPVTREVSRGDRAISLTRTEFSL
LEMLMANPRRVLTRSRILEEVWGYDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
>Mature_228_residues
MRILVVDDDRAVRESLRRSLTFNGYTVDLAVDGVDALEKATAQRPDALVLDVMMPRLDGLEVCRRLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRRAPDPGDTSETLRFADLSLDPVTREVSRGDRAISLTRTEFSL
LEMLMANPRRVLTRSRILEEVWGYDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=44.0528634361233, Blast_Score=183, Evalue=6e-48,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=41.3333333333333, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=40.2714932126697, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=40.5286343612335, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=40.1785714285714, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=37.8378378378378, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=36.7713004484305, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=40.3587443946188, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=37.0535714285714, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=38.4279475982533, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=32.579185520362, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.4675324675325, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.3859649122807, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=43.4782608695652, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=36.1111111111111, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=121, Percent_Identity=38.0165289256198, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=38.6792452830189, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=35.7723577235772, Blast_Score=68, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=121, Percent_Identity=29.7520661157025, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25607; Mature: 25607

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVDDDRAVRESLRRSLTFNGYTVDLAVDGVDALEKATAQRPDALVLDVMMPRLDGL
CEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCHHHHHHHHCCCCHH
EVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRRA
HHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PDPGDTSETLRFADLSLDPVTREVSRGDRAISLTRTEFSLLEMLMANPRRVLTRSRILEE
CCCCCCHHHEEEECCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHH
VWGYDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
HHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRILVVDDDRAVRESLRRSLTFNGYTVDLAVDGVDALEKATAQRPDALVLDVMMPRLDGL
CEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCHHHHHHHHCCCCHH
EVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRRA
HHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PDPGDTSETLRFADLSLDPVTREVSRGDRAISLTRTEFSLLEMLMANPRRVLTRSRILEE
CCCCCCHHHEEEECCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHH
VWGYDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
HHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA