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The map label for this gene is mprB [H]

Identifier: 54026937

GI number: 54026937

Start: 5178975

End: 5180441

Strand: Reverse

Name: mprB [H]

Synonym: nfa49630

Alternate gene names: 54026937

Gene position: 5180441-5178975 (Counterclockwise)

Preceding gene: 54026938

Following gene: 54026936

Centisome position: 86.04

GC content: 71.57

Gene sequence:

>1467_bases
ATGGCACGAAGCGCGCCCCGGCGGCCCGCCGTCGCCCCGGTCGGCCGGCCGGTCGAACCGCCGCCGATGCGTCCGCCGAT
GCCCCTGACCAGTTCGGTGTCGCTGCGCTGGCGGGTCACCCTGCTGGCCGCCTCGGTGGTGGCGATCGCGGTGGCGGTCA
CCTCGATCGCCGCCTACGCGATGGTGGCCAGGGCGCTCTACGCCGATGTCGACGAGCAGCTGCGCGCCCGCGCCGCCACC
ATGATCGACAACAATTTCGACAGCCTGGGTTTCCAATCGATCATCCTGGCCGGGCTGTACTCCAACGATGTCGGCGTGGC
GCTGATCTTCGCCGACCACAAGTCCTACATGCCCCCGCAGCAGACCATTCCGCCGGTGGGCGAGCAGGAACTCGGGGTCG
CCGACGGCCAGCTCGCCTCCTCGCTGCGCACGGTGAGCAGCCAGCGGGTGCTGGCCGTGCACACCAACTCCGGCGCCACG
CTGGTCATCTCGCAGCGGCTCGAACCGACCAGGGAGGTGCTCGACCGGCTGGCCTGGCTGCTGTTCGTGGTGGGCGGCTG
CGGCGTGGTCCTCGCGGCCGCGGCGGGCACCGCGGTGGGCCGCACCGGCCTGCGTCCGATCGCCCGGCTCACCGCCGCCA
CCGAACGCATCGCGCGCACCGACGACCTCACCCCGATCCCGGTGACCGGCGACGACGAATTGGCGCGGTTGACCGAGAGT
TTCAACACCATGCTGCGGGCGCTCGCCGAATCCCGCGACCGCCAGCGCAGGCTCGTCGCCGACGCGGGACACGAACTGCG
CACCCCGCTGACCTCGTTGCGCACCAACATGGAACTGCTCATCGCCTCCAGCCGCCCCGGCGCGCCGCAACTGCCCGAGC
AGGACATGGCCGAACTGCGCGCGGACGTGGTCGCCCAGATCGAGGAACTGTCCACCCTGGTCGGAGACCTGGTCGACCTG
GCGCGCGAGGACGCGCCGGAGACGGTCTACGACCGGGTCGACCTCGGTGAGGTGGCCGAACGCGCGCTGGAGCGCGCCCG
GCGCCGCCGCGCCGATGTGGAATTCGTGGCGGAACTGCGGCCCTGGTTCGTCTACGGCCACGACGCCGCGCTCGAACGCG
CGATCCTCAACGTGCTCGACAACGCCGCGAAGTGGAGCCCGGCGGGGGAGCAGGTCGGGGTGCGCATGCGCGAGACCGGC
CGCGGGCTGCTCGAGCTCACCGTGGACGACGCCGGTCCCGGTATCCCGCCCGAGGAGCGCGAGCTGGTGTTCGAGCGCTT
CTACCGCACCACCGCCTCCCGGTCGATGCCGGGATCGGGCCTCGGCCTGGCGATCGTCAAGCAGGTGGTGACCAAACACG
GCGGCACCATCACCATCGACACCTCCGACCGCGGCGGCGCCTGCATTCGTATCGTGTTACCCGGTGAGACGGGTGCCCCC
GGTCCTGGCCTGGACCAGCGGGAATGA

Upstream 100 bases:

>100_bases
TACCTGCGACGCAAGACCGAGGCCGAGGGCGAGCCGCGGCTGATCCACACCGTGCGCGGCGTCGGGTACGTGCTGCGCGA
GACCCCGCCGTAGGCGCGCG

Downstream 100 bases:

>100_bases
CGGCCGGGATTGACTTGTGATCCGCCGGGCACTCACCTCTCGGAAAACTGAAAGCACGGTCTCAGTCCGCTCTAAGCCGA
CCCGGCCAGGCTCGACGGTG

Product: putative two-component system sensor kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MARSAPRRPAVAPVGRPVEPPPMRPPMPLTSSVSLRWRVTLLAASVVAIAVAVTSIAAYAMVARALYADVDEQLRARAAT
MIDNNFDSLGFQSIILAGLYSNDVGVALIFADHKSYMPPQQTIPPVGEQELGVADGQLASSLRTVSSQRVLAVHTNSGAT
LVISQRLEPTREVLDRLAWLLFVVGGCGVVLAAAAGTAVGRTGLRPIARLTAATERIARTDDLTPIPVTGDDELARLTES
FNTMLRALAESRDRQRRLVADAGHELRTPLTSLRTNMELLIASSRPGAPQLPEQDMAELRADVVAQIEELSTLVGDLVDL
AREDAPETVYDRVDLGEVAERALERARRRRADVEFVAELRPWFVYGHDAALERAILNVLDNAAKWSPAGEQVGVRMRETG
RGLLELTVDDAGPGIPPEERELVFERFYRTTASRSMPGSGLGLAIVKQVVTKHGGTITIDTSDRGGACIRIVLPGETGAP
GPGLDQRE

Sequences:

>Translated_488_residues
MARSAPRRPAVAPVGRPVEPPPMRPPMPLTSSVSLRWRVTLLAASVVAIAVAVTSIAAYAMVARALYADVDEQLRARAAT
MIDNNFDSLGFQSIILAGLYSNDVGVALIFADHKSYMPPQQTIPPVGEQELGVADGQLASSLRTVSSQRVLAVHTNSGAT
LVISQRLEPTREVLDRLAWLLFVVGGCGVVLAAAAGTAVGRTGLRPIARLTAATERIARTDDLTPIPVTGDDELARLTES
FNTMLRALAESRDRQRRLVADAGHELRTPLTSLRTNMELLIASSRPGAPQLPEQDMAELRADVVAQIEELSTLVGDLVDL
AREDAPETVYDRVDLGEVAERALERARRRRADVEFVAELRPWFVYGHDAALERAILNVLDNAAKWSPAGEQVGVRMRETG
RGLLELTVDDAGPGIPPEERELVFERFYRTTASRSMPGSGLGLAIVKQVVTKHGGTITIDTSDRGGACIRIVLPGETGAP
GPGLDQRE
>Mature_487_residues
ARSAPRRPAVAPVGRPVEPPPMRPPMPLTSSVSLRWRVTLLAASVVAIAVAVTSIAAYAMVARALYADVDEQLRARAATM
IDNNFDSLGFQSIILAGLYSNDVGVALIFADHKSYMPPQQTIPPVGEQELGVADGQLASSLRTVSSQRVLAVHTNSGATL
VISQRLEPTREVLDRLAWLLFVVGGCGVVLAAAAGTAVGRTGLRPIARLTAATERIARTDDLTPIPVTGDDELARLTESF
NTMLRALAESRDRQRRLVADAGHELRTPLTSLRTNMELLIASSRPGAPQLPEQDMAELRADVVAQIEELSTLVGDLVDLA
REDAPETVYDRVDLGEVAERALERARRRRADVEFVAELRPWFVYGHDAALERAILNVLDNAAKWSPAGEQVGVRMRETGR
GLLELTVDDAGPGIPPEERELVFERFYRTTASRSMPGSGLGLAIVKQVVTKHGGTITIDTSDRGGACIRIVLPGETGAPG
PGLDQRE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=326, Percent_Identity=29.7546012269939, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=32.7402135231317, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=32.0143884892086, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789808, Length=305, Percent_Identity=31.1475409836066, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788279, Length=302, Percent_Identity=28.476821192053, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=33.0677290836653, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=32.7510917030568, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=29.8305084745763, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=466, Percent_Identity=25.7510729613734, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787894, Length=297, Percent_Identity=28.2828282828283, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1787374, Length=307, Percent_Identity=27.0358306188925, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790551, Length=266, Percent_Identity=28.1954887218045, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=26.530612244898, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=332, Percent_Identity=24.3975903614458, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=23.0125523012552, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=24.4343891402715, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=26.9911504424779, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=25.5882352941176, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1790300, Length=234, Percent_Identity=28.6324786324786, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52538; Mature: 52406

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSAPRRPAVAPVGRPVEPPPMRPPMPLTSSVSLRWRVTLLAASVVAIAVAVTSIAAYA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
MVARALYADVDEQLRARAATMIDNNFDSLGFQSIILAGLYSNDVGVALIFADHKSYMPPQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
QTIPPVGEQELGVADGQLASSLRTVSSQRVLAVHTNSGATLVISQRLEPTREVLDRLAWL
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
LFVVGGCGVVLAAAAGTAVGRTGLRPIARLTAATERIARTDDLTPIPVTGDDELARLTES
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
FNTMLRALAESRDRQRRLVADAGHELRTPLTSLRTNMELLIASSRPGAPQLPEQDMAELR
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHCCEEEEEECCCCCCCCCCHHHHHHHH
ADVVAQIEELSTLVGDLVDLAREDAPETVYDRVDLGEVAERALERARRRRADVEFVAELR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHCC
PWFVYGHDAALERAILNVLDNAAKWSPAGEQVGVRMRETGRGLLELTVDDAGPGIPPEER
CEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHCCCCEEEEEECCCCCCCCCHHH
ELVFERFYRTTASRSMPGSGLGLAIVKQVVTKHGGTITIDTSDRGGACIRIVLPGETGAP
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCC
GPGLDQRE
CCCCCCCC
>Mature Secondary Structure 
ARSAPRRPAVAPVGRPVEPPPMRPPMPLTSSVSLRWRVTLLAASVVAIAVAVTSIAAYA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
MVARALYADVDEQLRARAATMIDNNFDSLGFQSIILAGLYSNDVGVALIFADHKSYMPPQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
QTIPPVGEQELGVADGQLASSLRTVSSQRVLAVHTNSGATLVISQRLEPTREVLDRLAWL
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
LFVVGGCGVVLAAAAGTAVGRTGLRPIARLTAATERIARTDDLTPIPVTGDDELARLTES
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
FNTMLRALAESRDRQRRLVADAGHELRTPLTSLRTNMELLIASSRPGAPQLPEQDMAELR
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHCCEEEEEECCCCCCCCCCHHHHHHHH
ADVVAQIEELSTLVGDLVDLAREDAPETVYDRVDLGEVAERALERARRRRADVEFVAELR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHCC
PWFVYGHDAALERAILNVLDNAAKWSPAGEQVGVRMRETGRGLLELTVDDAGPGIPPEER
CEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHCCCCEEEEEECCCCCCCCCHHH
ELVFERFYRTTASRSMPGSGLGLAIVKQVVTKHGGTITIDTSDRGGACIRIVLPGETGAP
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCC
GPGLDQRE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA