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The map label for this gene is pth

Identifier: 54026867

GI number: 54026867

Start: 5106815

End: 5107396

Strand: Reverse

Name: pth

Synonym: nfa48930

Alternate gene names: 54026867

Gene position: 5107396-5106815 (Counterclockwise)

Preceding gene: 54026868

Following gene: 54026861

Centisome position: 84.82

GC content: 70.79

Gene sequence:

>582_bases
ATGACCGGTCCTTCGACCGGGCCCGCGCTCGTGGTCGGCCTGGGTAACCCGGGCTCGGAATACGAGCGCACCCGGCACAA
TGTCGGTTTTCTGGTCGCCGACGTGCTCGCCGAGCGCGTCGGCGACCGTTTTGCCGTGCACAAGAAGTCCGGCGCGGACC
TGCTGCAGGCTCGGCTGGACGGGCGGCAGGTGCTCATCGCCAAGCCGCGTTCCTACATGAACCTGTCCGGTCGGCCGGTC
GCGGCGCTGGCCCGGTTCTTCTCGGTGCCGCCGACCGAGGTCATCGTCGTGCACGACGAACTGGATCTGCCGTTCGGTGC
CGTGCGGCTCAAGCGCGGCGGCGGCGAGGGCGGGCACAACGGGCTGCGCTCCATCTCCAGCGCGCTCACCACCAAGGACT
ACCTGCGCACCCGCATCGGCATCGGCCGCCCCCCGGGTCGGCAGGACCCGGCCGACTTCGTGCTCAAGCCGTTCGCGGCC
GCCGAGCGCAAGGAGGTGCCGGTGATCGTGGAGCAGGCCGCCGACGCGGTGGAGCTGCTGCTGCGCGTCGGTCTCGAGGC
CGCGCAGAACCAACTGCACTGA

Upstream 100 bases:

>100_bases
GAGCTGCTGGTCGTCAACGTGATCGCCGCGCCCGCCGCCGAGCCCGCTCCGGGTGAGGAAGCGGCCGAGGCCGAGGGCGA
GAGCGCCGAATAACTCGCCG

Downstream 100 bases:

>100_bases
GCCGCCGACCGCGTGAGCCGGGACCGCGCCGAGTCGGGAGTTGTCGCCGAGTCGGGAGTTGTCCTGAGCCGCAGCGGCTT
TCAGAACCGGTAAGCGGTCT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTGPSTGPALVVGLGNPGSEYERTRHNVGFLVADVLAERVGDRFAVHKKSGADLLQARLDGRQVLIAKPRSYMNLSGRPV
AALARFFSVPPTEVIVVHDELDLPFGAVRLKRGGGEGGHNGLRSISSALTTKDYLRTRIGIGRPPGRQDPADFVLKPFAA
AERKEVPVIVEQAADAVELLLRVGLEAAQNQLH

Sequences:

>Translated_193_residues
MTGPSTGPALVVGLGNPGSEYERTRHNVGFLVADVLAERVGDRFAVHKKSGADLLQARLDGRQVLIAKPRSYMNLSGRPV
AALARFFSVPPTEVIVVHDELDLPFGAVRLKRGGGEGGHNGLRSISSALTTKDYLRTRIGIGRPPGRQDPADFVLKPFAA
AERKEVPVIVEQAADAVELLLRVGLEAAQNQLH
>Mature_192_residues
TGPSTGPALVVGLGNPGSEYERTRHNVGFLVADVLAERVGDRFAVHKKSGADLLQARLDGRQVLIAKPRSYMNLSGRPVA
ALARFFSVPPTEVIVVHDELDLPFGAVRLKRGGGEGGHNGLRSISSALTTKDYLRTRIGIGRPPGRQDPADFVLKPFAAA
ERKEVPVIVEQAADAVELLLRVGLEAAQNQLH

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=41.1764705882353, Blast_Score=117, Evalue=5e-27,
Organism=Escherichia coli, GI1787455, Length=185, Percent_Identity=43.2432432432432, Blast_Score=123, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6321983, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_NOCFA (Q5YPZ6)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_121109.1
- ProteinModelPortal:   Q5YPZ6
- SMR:   Q5YPZ6
- GeneID:   3111407
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa48930
- NMPDR:   fig|247156.1.peg.4706
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- ProtClustDB:   PRK05426
- BioCyc:   NFAR247156:NFA48930-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20701; Mature: 20570

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPSTGPALVVGLGNPGSEYERTRHNVGFLVADVLAERVGDRFAVHKKSGADLLQARLD
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCC
GRQVLIAKPRSYMNLSGRPVAALARFFSVPPTEVIVVHDELDLPFGAVRLKRGGGEGGHN
CCEEEEECCHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCHH
GLRSISSALTTKDYLRTRIGIGRPPGRQDPADFVLKPFAAAERKEVPVIVEQAADAVELL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHCCCCCCHHHHHHHHHHHHH
LRVGLEAAQNQLH
HHHCHHHHHHCCC
>Mature Secondary Structure 
TGPSTGPALVVGLGNPGSEYERTRHNVGFLVADVLAERVGDRFAVHKKSGADLLQARLD
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCC
GRQVLIAKPRSYMNLSGRPVAALARFFSVPPTEVIVVHDELDLPFGAVRLKRGGGEGGHN
CCEEEEECCHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCHH
GLRSISSALTTKDYLRTRIGIGRPPGRQDPADFVLKPFAAAERKEVPVIVEQAADAVELL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHCCCCCCHHHHHHHHHHHHH
LRVGLEAAQNQLH
HHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA