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The map label for this gene is fadE39 [H]

Identifier: 54026647

GI number: 54026647

Start: 4874920

End: 4876050

Strand: Reverse

Name: fadE39 [H]

Synonym: nfa46740

Alternate gene names: 54026647

Gene position: 4876050-4874920 (Counterclockwise)

Preceding gene: 54026648

Following gene: 54026645

Centisome position: 80.98

GC content: 72.68

Gene sequence:

>1131_bases
ATGGATTTCGATCTCACCGATGAACAGGTCATGCTGCGCGACACCGTGCGCGATCTGCTGGCCCGCACCTACGACCCGGA
GACCCGGCTGAAGGTGACCGACACCGAGCTGGGCTGGAGCCGCGACGTGTGGCGCCAGCTCGCCGAACTCGGGGTGCTCG
GCCTCGGTTTCGCCGAGGAGTTCGGCGGCGCGGGCGCGACCGCGGTCGAGACGCTGGTGGTGCTCGAGGAGATCGGGCGC
AGGCTCGCGCCCGAGCCGCTGCTGGACGCGGTCGTGGTACCCGGCACCCTGGTGGCGGCTCTCGGCACCGACGCCCAGCG
CGCGCAGATCCTGCCCGCCGTCGCGGGCGGGGAACAGCTGCTGGCCTTCGCGCACGACGAGCCCGGGGTGCGCTGGCCCG
CCACCGACCTGTCGACCCGGGCCGAACAGTCCGGCGACGGCTACACGCTGACCGGCGTGAAGAACCCGGTGCCGCACGGT
GATTGCGCCGATCGCGTGATCGTCAGCGCGGTGCTGCCCGGCGGCGGCGTCGGCCTGTTCCTCGTCGCGCCCGACGGCGC
GGGCGTCACCAGGACGGCCTACCGCACCGTCGACAGCCGTCGCGGCGCGCAGTTCGAATTCGCGTCCGCGCCCGCCGAAC
TGCTCGGCGAGCCGGGCGCCGACGCGGCCGCCGCGATCCGCGAGGCGCTGGGGTACGCGCACGCGGGGTTGTGTGCCGAA
TCGGTCGGCGCGATGGCGGAGGCGCTGCGGCTGACCACCGAATACCTCGGCACCCGTAAGCAGTTCGGCGTCACGCTGTC
GAAGTTCCAGACCCTGACCCAGCGGGCGGCGAACATGTACGTCTCGCTGGAGCTGGCGCGCAGCATGAGCCTGTACCTCA
CCGCGGCGGTCGCCGACGGGGCGGTCGACCCGGTGATCATCTCCCGCGCCCGGCTCCAGGTGGCCAAGGCCGCCCGCCAC
GTCGGGCAGGAGGCGATCCAGATGCACGGCGGTATCGGCGTCACCGCCGAGTACCCGGTCGGCCACTACGTCGCCCGGCT
CACCGCGATCGGTCGCACGCTCGGCGGCGAGCTCGAGCATCTGACCGTGCTGCGGACGGCGACCAGCGGATACGACCTGG
TCGAGCTCTAG

Upstream 100 bases:

>100_bases
CGGCTACCTCAACTACCGCAAGACCACCATCTACGGAGGCTCGAACGAGGTGCAGCGCACCATCATCGCCTCCACGATCC
TCGGATTGTGAGGCCAGGTC

Downstream 100 bases:

>100_bases
CGGCGGGCGATCCGGGCGGCGGTGCGCGCGAGCGTGCCGCCGCCCTTCGCGTGTCCGGTCACTCGGTCTCGTCGGGTGAT
TCGGTGCGGGTGACCGGTTC

Product: putative acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MDFDLTDEQVMLRDTVRDLLARTYDPETRLKVTDTELGWSRDVWRQLAELGVLGLGFAEEFGGAGATAVETLVVLEEIGR
RLAPEPLLDAVVVPGTLVAALGTDAQRAQILPAVAGGEQLLAFAHDEPGVRWPATDLSTRAEQSGDGYTLTGVKNPVPHG
DCADRVIVSAVLPGGGVGLFLVAPDGAGVTRTAYRTVDSRRGAQFEFASAPAELLGEPGADAAAAIREALGYAHAGLCAE
SVGAMAEALRLTTEYLGTRKQFGVTLSKFQTLTQRAANMYVSLELARSMSLYLTAAVADGAVDPVIISRARLQVAKAARH
VGQEAIQMHGGIGVTAEYPVGHYVARLTAIGRTLGGELEHLTVLRTATSGYDLVEL

Sequences:

>Translated_376_residues
MDFDLTDEQVMLRDTVRDLLARTYDPETRLKVTDTELGWSRDVWRQLAELGVLGLGFAEEFGGAGATAVETLVVLEEIGR
RLAPEPLLDAVVVPGTLVAALGTDAQRAQILPAVAGGEQLLAFAHDEPGVRWPATDLSTRAEQSGDGYTLTGVKNPVPHG
DCADRVIVSAVLPGGGVGLFLVAPDGAGVTRTAYRTVDSRRGAQFEFASAPAELLGEPGADAAAAIREALGYAHAGLCAE
SVGAMAEALRLTTEYLGTRKQFGVTLSKFQTLTQRAANMYVSLELARSMSLYLTAAVADGAVDPVIISRARLQVAKAARH
VGQEAIQMHGGIGVTAEYPVGHYVARLTAIGRTLGGELEHLTVLRTATSGYDLVEL
>Mature_376_residues
MDFDLTDEQVMLRDTVRDLLARTYDPETRLKVTDTELGWSRDVWRQLAELGVLGLGFAEEFGGAGATAVETLVVLEEIGR
RLAPEPLLDAVVVPGTLVAALGTDAQRAQILPAVAGGEQLLAFAHDEPGVRWPATDLSTRAEQSGDGYTLTGVKNPVPHG
DCADRVIVSAVLPGGGVGLFLVAPDGAGVTRTAYRTVDSRRGAQFEFASAPAELLGEPGADAAAAIREALGYAHAGLCAE
SVGAMAEALRLTTEYLGTRKQFGVTLSKFQTLTQRAANMYVSLELARSMSLYLTAAVADGAVDPVIISRARLQVAKAARH
VGQEAIQMHGGIGVTAEYPVGHYVARLTAIGRTLGGELEHLTVLRTATSGYDLVEL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=364, Percent_Identity=28.021978021978, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI226958414, Length=328, Percent_Identity=28.0487804878049, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4501859, Length=354, Percent_Identity=27.9661016949153, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557233, Length=363, Percent_Identity=28.6501377410468, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI7656849, Length=371, Percent_Identity=26.1455525606469, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=25.9842519685039, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=25.9668508287293, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501857, Length=351, Percent_Identity=24.7863247863248, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21361497, Length=343, Percent_Identity=29.7376093294461, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI76496475, Length=355, Percent_Identity=26.4788732394366, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4557235, Length=355, Percent_Identity=26.4788732394366, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=24.8663101604278, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=24.8663101604278, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=25.4545454545455, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=367, Percent_Identity=28.0653950953678, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17569725, Length=358, Percent_Identity=27.9329608938547, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17506239, Length=356, Percent_Identity=25.561797752809, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=361, Percent_Identity=28.2548476454294, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17534899, Length=357, Percent_Identity=26.0504201680672, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17570075, Length=357, Percent_Identity=26.6106442577031, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=26.0162601626016, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=321, Percent_Identity=28.3489096573209, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71990804, Length=253, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32563615, Length=237, Percent_Identity=25.7383966244726, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534353, Length=391, Percent_Identity=23.5294117647059, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=373, Percent_Identity=28.9544235924933, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356377, Length=363, Percent_Identity=29.2011019283747, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=26.8493150684932, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646207, Length=362, Percent_Identity=26.5193370165746, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=23.7597911227154, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24660351, Length=360, Percent_Identity=25.5555555555556, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39676; Mature: 39676

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDLTDEQVMLRDTVRDLLARTYDPETRLKVTDTELGWSRDVWRQLAELGVLGLGFAEE
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHH
FGGAGATAVETLVVLEEIGRRLAPEPLLDAVVVPGTLVAALGTDAQRAQILPAVAGGEQL
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCHHHHHCCCEECCCCEE
LAFAHDEPGVRWPATDLSTRAEQSGDGYTLTGVKNPVPHGDCADRVIVSAVLPGGGVGLF
EEEECCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEE
LVAPDGAGVTRTAYRTVDSRRGAQFEFASAPAELLGEPGADAAAAIREALGYAHAGLCAE
EECCCCCCCHHHHHHHHHHCCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SVGAMAEALRLTTEYLGTRKQFGVTLSKFQTLTQRAANMYVSLELARSMSLYLTAAVADG
HHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHEEEEEHHHCHHEEEEEEHHCC
AVDPVIISRARLQVAKAARHVGQEAIQMHGGIGVTAEYPVGHYVARLTAIGRTLGGELEH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHH
LTVLRTATSGYDLVEL
EEEEEECCCCCCCCCC
>Mature Secondary Structure
MDFDLTDEQVMLRDTVRDLLARTYDPETRLKVTDTELGWSRDVWRQLAELGVLGLGFAEE
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHH
FGGAGATAVETLVVLEEIGRRLAPEPLLDAVVVPGTLVAALGTDAQRAQILPAVAGGEQL
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCHHHHHCCCEECCCCEE
LAFAHDEPGVRWPATDLSTRAEQSGDGYTLTGVKNPVPHGDCADRVIVSAVLPGGGVGLF
EEEECCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEE
LVAPDGAGVTRTAYRTVDSRRGAQFEFASAPAELLGEPGADAAAAIREALGYAHAGLCAE
EECCCCCCCHHHHHHHHHHCCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SVGAMAEALRLTTEYLGTRKQFGVTLSKFQTLTQRAANMYVSLELARSMSLYLTAAVADG
HHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHEEEEEHHHCHHEEEEEEHHCC
AVDPVIISRARLQVAKAARHVGQEAIQMHGGIGVTAEYPVGHYVARLTAIGRTLGGELEH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHH
LTVLRTATSGYDLVEL
EEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]