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The map label for this gene is lytC [H]

Identifier: 54026292

GI number: 54026292

Start: 4478704

End: 4480023

Strand: Reverse

Name: lytC [H]

Synonym: nfa43210

Alternate gene names: 54026292

Gene position: 4480023-4478704 (Counterclockwise)

Preceding gene: 54026294

Following gene: 54026291

Centisome position: 74.4

GC content: 75.61

Gene sequence:

>1320_bases
ATGAAGCCGACCGTCATCACCGCCGCCTGCGCCCTCGCACTGGCCGTCGTGGGAACCGGGCCCGCGGTCGCCGAACCGGT
GTCCCCGGAGATGGCCACCAAGCTGGCCGGCCGCACCGTCTTCCTGGACCCCGGGCACCAGGGACCGAACCACTCCGAAG
ACCTGTCCCGCCAGGTCGACAACGGCCGCGGCGGTACCAAGGACTGCCAGACCACCGGCATGACCACCGTCAACGGGGTC
GCCGAACACACCATCAACTGGAACGTCGCCCAGCTGGTGAAGGCGTCGTTGGAGAGCCTCGGCGCGCGGGTCGTGCTGAG
CCGGCAGGACGACAGCGGCTGGGGCGGCTGCGTGGACGAGCGCGCCCGCGCCGCCAACGAGTCCGGCGCCGCCGTCGCGG
TCAGCATCCACGCCGACAGCGCGCCCGCGAGCGAGCGCGGTTTCCACCTGATCGTCCCGCAGTTGCCGGTCCCCGATCCC
GAGGTCGATCGGGTGCAGTCCGGACCCGGACTGGCGGTGTCGAAGGCCGTCCGGGACGCCTACGTGCAGGCCGGTTTCCC
GGCCGCCACCTACGCCGGCGTCCGGGAGGGCCTGCAGTCGCGCGCCGATGTCGCCGGGCCCGCGCTGACCGCGGTGCCGA
ACGTCTTCGTGGAGATGGGCAACGGCGCCAACCCCGAGGACGCCGCCGTACTCGAATCCGGCGACGGACAGCTGAAACAC
GCCATCGCCATCACCACCGGCGTGGTGAGCTACCTGCTCAACGCCCCCGTCGACGCGGGCTCCGGCTCGGCCGACCTGCC
CGCGGGCGCGGCCCCCGCCCGCACCGAGCCGAGCGACCCGCCGCCCGCCGCCCCGGAGAACGCCGCCCCGGAGAACGCGC
CCACCACGCCGTCGCCCACGACGCCAGGCTTCACCGCACCGACCGCCACCGCACCCGCACCGGGTGGGGCACCGGCACCC
GGCGCTACCGCACCCGCTCCCGGCACGGCGACCACTCCGGGTGGCGCGACTGCTCCGGGCGCCGCGCCGTCACCTGCCCC
CGGTGCCGCAACGACACCCGCGCCCGGCGCCGCCCCCACGCCGGGCACCACCGCCACACCCGCGCCGGGCGCGCGCACGA
CGCCCGCACCGGCCGGTACCGGCACACCCGCCACCCCGACCTCGTCGGCCGCCCCCGCGGTCACCGGCCCGGCGGGCAAG
GCACTGGAGGTGCTCATGCCCCTGGCCCGCGCGCTGGGCATGGACCGGGAGGCCGTCACCGCCGAACTGATCAACCTCGC
CTACACCCTGGCCGCCACCCTGTTCCCGCCGACCAGGTAG

Upstream 100 bases:

>100_bases
GGGTTGTCTGGGTGATGCTGGCGTTGCCAGAGTGAAGCGTTGGGTTTGGTGTTGCCAATGGGAAGGGAGGGGTGCTCCGT
TCCGGGGCACCGACCGAAAC

Downstream 100 bases:

>100_bases
GAAACCTGCCCGACCGCCGGGCTCCGCTCAGGCACGCACGCTCGGCCGGCCCGAGCGAGGTGGACGCCGACCGTCTCCAC
CTCCGGCGGATCCCGCCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKPTVITAACALALAVVGTGPAVAEPVSPEMATKLAGRTVFLDPGHQGPNHSEDLSRQVDNGRGGTKDCQTTGMTTVNGV
AEHTINWNVAQLVKASLESLGARVVLSRQDDSGWGGCVDERARAANESGAAVAVSIHADSAPASERGFHLIVPQLPVPDP
EVDRVQSGPGLAVSKAVRDAYVQAGFPAATYAGVREGLQSRADVAGPALTAVPNVFVEMGNGANPEDAAVLESGDGQLKH
AIAITTGVVSYLLNAPVDAGSGSADLPAGAAPARTEPSDPPPAAPENAAPENAPTTPSPTTPGFTAPTATAPAPGGAPAP
GATAPAPGTATTPGGATAPGAAPSPAPGAATTPAPGAAPTPGTTATPAPGARTTPAPAGTGTPATPTSSAAPAVTGPAGK
ALEVLMPLARALGMDREAVTAELINLAYTLAATLFPPTR

Sequences:

>Translated_439_residues
MKPTVITAACALALAVVGTGPAVAEPVSPEMATKLAGRTVFLDPGHQGPNHSEDLSRQVDNGRGGTKDCQTTGMTTVNGV
AEHTINWNVAQLVKASLESLGARVVLSRQDDSGWGGCVDERARAANESGAAVAVSIHADSAPASERGFHLIVPQLPVPDP
EVDRVQSGPGLAVSKAVRDAYVQAGFPAATYAGVREGLQSRADVAGPALTAVPNVFVEMGNGANPEDAAVLESGDGQLKH
AIAITTGVVSYLLNAPVDAGSGSADLPAGAAPARTEPSDPPPAAPENAAPENAPTTPSPTTPGFTAPTATAPAPGGAPAP
GATAPAPGTATTPGGATAPGAAPSPAPGAATTPAPGAAPTPGTTATPAPGARTTPAPAGTGTPATPTSSAAPAVTGPAGK
ALEVLMPLARALGMDREAVTAELINLAYTLAATLFPPTR
>Mature_439_residues
MKPTVITAACALALAVVGTGPAVAEPVSPEMATKLAGRTVFLDPGHQGPNHSEDLSRQVDNGRGGTKDCQTTGMTTVNGV
AEHTINWNVAQLVKASLESLGARVVLSRQDDSGWGGCVDERARAANESGAAVAVSIHADSAPASERGFHLIVPQLPVPDP
EVDRVQSGPGLAVSKAVRDAYVQAGFPAATYAGVREGLQSRADVAGPALTAVPNVFVEMGNGANPEDAAVLESGDGQLKH
AIAITTGVVSYLLNAPVDAGSGSADLPAGAAPARTEPSDPPPAAPENAAPENAPTTPSPTTPGFTAPTATAPAPGGAPAP
GATAPAPGTATTPGGATAPGAAPSPAPGAATTPAPGAAPTPGTTATPAPGARTTPAPAGTGTPATPTSSAAPAVTGPAGK
ALEVLMPLARALGMDREAVTAELINLAYTLAATLFPPTR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 42932; Mature: 42932

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTVITAACALALAVVGTGPAVAEPVSPEMATKLAGRTVFLDPGHQGPNHSEDLSRQVD
CCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHH
NGRGGTKDCQTTGMTTVNGVAEHTINWNVAQLVKASLESLGARVVLSRQDDSGWGGCVDE
CCCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHH
RARAANESGAAVAVSIHADSAPASERGFHLIVPQLPVPDPEVDRVQSGPGLAVSKAVRDA
HHHHCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHH
YVQAGFPAATYAGVREGLQSRADVAGPALTAVPNVFVEMGNGANPEDAAVLESGDGQLKH
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCEEECCCCCEEH
AIAITTGVVSYLLNAPVDAGSGSADLPAGAAPARTEPSDPPPAAPENAAPENAPTTPSPT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPGFTAPTATAPAPGGAPAPGATAPAPGTATTPGGATAPGAAPSPAPGAATTPAPGAAPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGTTATPAPGARTTPAPAGTGTPATPTSSAAPAVTGPAGKALEVLMPLARALGMDREAVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
AELINLAYTLAATLFPPTR
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKPTVITAACALALAVVGTGPAVAEPVSPEMATKLAGRTVFLDPGHQGPNHSEDLSRQVD
CCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHH
NGRGGTKDCQTTGMTTVNGVAEHTINWNVAQLVKASLESLGARVVLSRQDDSGWGGCVDE
CCCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHH
RARAANESGAAVAVSIHADSAPASERGFHLIVPQLPVPDPEVDRVQSGPGLAVSKAVRDA
HHHHCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHH
YVQAGFPAATYAGVREGLQSRADVAGPALTAVPNVFVEMGNGANPEDAAVLESGDGQLKH
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCEEECCCCCEEH
AIAITTGVVSYLLNAPVDAGSGSADLPAGAAPARTEPSDPPPAAPENAAPENAPTTPSPT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPGFTAPTATAPAPGGAPAPGATAPAPGTATTPGGATAPGAAPSPAPGAATTPAPGAAPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGTTATPAPGARTTPAPAGTGTPATPTSSAAPAVTGPAGKALEVLMPLARALGMDREAVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
AELINLAYTLAATLFPPTR
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]