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The map label for this gene is moaA [H]

Identifier: 54026287

GI number: 54026287

Start: 4473486

End: 4474529

Strand: Reverse

Name: moaA [H]

Synonym: nfa43160

Alternate gene names: 54026287

Gene position: 4474529-4473486 (Counterclockwise)

Preceding gene: 54026291

Following gene: 54026286

Centisome position: 74.31

GC content: 72.22

Gene sequence:

>1044_bases
ATGGGCATCCCCGCCGTGCGATCCGGGCGGCCCTCGCTCGACGGACGGCCCGATACGCCCGTGCTCATCGACCGCTTCGG
CCGGGTCGCCCGCGACCTGCGCGTGTCCATCACCGAGAAGTGCTCGCTGCGCTGTACCTACTGCATGCCCGAGGAGGGCC
TGCCGCCCATCCCGGCCGAGGAACTGCTGACCGTGGACGAGATCGTCCGCCTGGTCGCCCTGGCCGTGGAGGAACTGGGG
GTGCGGGAGGTCCGGTTCACCGGCGGTGAGCCGCTGCTGCGGCGTGACCTGGAGCGGATCATCGCGGGCTGCCACGCACG
GGTGCCGCAGACGCCGCTGGCCATGACTACCAACGGTGTCGGCCTCGCGCACCGGGCGCGGGGGCTGGCCGCCGCCGGGT
TGCACCGGGTGAACGTCTCGCTCGACACCGTCGACCGGCTCGGCTTCGCCCGCCTCACCCGCCGCGACCGCCTCGACTCG
GTGCTCGCCGGCATCCGCGCCGCGCGGGCGGCGGGCCTGGCCCCGGTCAAGGTGAACGCCGTGCTGATGCGCCAAACCCT
CGCCGACGCACCGGATCTGCTGCGATGGTGTCTGGACGAGGAGTGCGAGTTGCGGTTCATCGAAGAAATGCCGCTGGACG
CCGACCACGAGTGGGCGCGCGCCAACATGGTCACCGCCGCCGAACTGCTCGACGTGCTCGGCACCCGCTTCGCGCTCACC
GAGGCCGGTCGCGCCGACCCGTCCGCGCCCGCGGAGAAGTGGCTCGTCGACGGCGGCCCGGCGACCGTGGGCATCATCGC
GACGGTGACCCGCAAGTTCTGCGACACCTGCGACCGCACCCGGCTCACCGCCGACGGCATGCTGCGCTCCTGCCTGTTCA
GCGATCAGGAGTTCGACGTGCGCCAGGCCATGCGGGCGGGCGCCGACGACGCCGAGATCGCGGCCATCTGGCGCGGCGCG
ATGTGGCAGAAGTGGGCCGGGCACGGCATCGAATCGGAGAACTTCGTCCCGCCCGAACGCACGATGGGAGCCATCGGTGG
TTGA

Upstream 100 bases:

>100_bases
GACGTGGTGATTTGTGAGAGCCCCAGGTCGAACGGGTTCTCCCGTCGGGCCTGCCCGTGTCGGGGGCAGCGGTCATAATG
GAGCGGTGACGTTGGTCGAT

Downstream 100 bases:

>100_bases
GATCCGCTATTTCGCCGCCATCGCCGACGCGGTCGGCAAGGAGACCGAACAGCTCGACCTGCCACCCGGCGCCACCGTCG
CCGACCTGCGCACCACCCTC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MGIPAVRSGRPSLDGRPDTPVLIDRFGRVARDLRVSITEKCSLRCTYCMPEEGLPPIPAEELLTVDEIVRLVALAVEELG
VREVRFTGGEPLLRRDLERIIAGCHARVPQTPLAMTTNGVGLAHRARGLAAAGLHRVNVSLDTVDRLGFARLTRRDRLDS
VLAGIRAARAAGLAPVKVNAVLMRQTLADAPDLLRWCLDEECELRFIEEMPLDADHEWARANMVTAAELLDVLGTRFALT
EAGRADPSAPAEKWLVDGGPATVGIIATVTRKFCDTCDRTRLTADGMLRSCLFSDQEFDVRQAMRAGADDAEIAAIWRGA
MWQKWAGHGIESENFVPPERTMGAIGG

Sequences:

>Translated_347_residues
MGIPAVRSGRPSLDGRPDTPVLIDRFGRVARDLRVSITEKCSLRCTYCMPEEGLPPIPAEELLTVDEIVRLVALAVEELG
VREVRFTGGEPLLRRDLERIIAGCHARVPQTPLAMTTNGVGLAHRARGLAAAGLHRVNVSLDTVDRLGFARLTRRDRLDS
VLAGIRAARAAGLAPVKVNAVLMRQTLADAPDLLRWCLDEECELRFIEEMPLDADHEWARANMVTAAELLDVLGTRFALT
EAGRADPSAPAEKWLVDGGPATVGIIATVTRKFCDTCDRTRLTADGMLRSCLFSDQEFDVRQAMRAGADDAEIAAIWRGA
MWQKWAGHGIESENFVPPERTMGAIGG
>Mature_346_residues
GIPAVRSGRPSLDGRPDTPVLIDRFGRVARDLRVSITEKCSLRCTYCMPEEGLPPIPAEELLTVDEIVRLVALAVEELGV
REVRFTGGEPLLRRDLERIIAGCHARVPQTPLAMTTNGVGLAHRARGLAAAGLHRVNVSLDTVDRLGFARLTRRDRLDSV
LAGIRAARAAGLAPVKVNAVLMRQTLADAPDLLRWCLDEECELRFIEEMPLDADHEWARANMVTAAELLDVLGTRFALTE
AGRADPSAPAEKWLVDGGPATVGIIATVTRKFCDTCDRTRLTADGMLRSCLFSDQEFDVRQAMRAGADDAEIAAIWRGAM
WQKWAGHGIESENFVPPERTMGAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=334, Percent_Identity=38.622754491018, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI22027536, Length=334, Percent_Identity=38.622754491018, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=35.0609756097561, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=347, Percent_Identity=35.1585014409222, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=329, Percent_Identity=34.9544072948328, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=329, Percent_Identity=35.258358662614, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI28574488, Length=334, Percent_Identity=39.2215568862275, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28574490, Length=316, Percent_Identity=38.9240506329114, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37865; Mature: 37734

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIPAVRSGRPSLDGRPDTPVLIDRFGRVARDLRVSITEKCSLRCTYCMPEEGLPPIPAE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHH
ELLTVDEIVRLVALAVEELGVREVRFTGGEPLLRRDLERIIAGCHARVPQTPLAMTTNGV
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
GLAHRARGLAAAGLHRVNVSLDTVDRLGFARLTRRDRLDSVLAGIRAARAAGLAPVKVNA
CHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VLMRQTLADAPDLLRWCLDEECELRFIEEMPLDADHEWARANMVTAAELLDVLGTRFALT
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAGRADPSAPAEKWLVDGGPATVGIIATVTRKFCDTCDRTRLTADGMLRSCLFSDQEFDV
CCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHH
RQAMRAGADDAEIAAIWRGAMWQKWAGHGIESENFVPPERTMGAIGG
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
GIPAVRSGRPSLDGRPDTPVLIDRFGRVARDLRVSITEKCSLRCTYCMPEEGLPPIPAE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHH
ELLTVDEIVRLVALAVEELGVREVRFTGGEPLLRRDLERIIAGCHARVPQTPLAMTTNGV
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
GLAHRARGLAAAGLHRVNVSLDTVDRLGFARLTRRDRLDSVLAGIRAARAAGLAPVKVNA
CHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VLMRQTLADAPDLLRWCLDEECELRFIEEMPLDADHEWARANMVTAAELLDVLGTRFALT
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAGRADPSAPAEKWLVDGGPATVGIIATVTRKFCDTCDRTRLTADGMLRSCLFSDQEFDV
CCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHH
RQAMRAGADDAEIAAIWRGAMWQKWAGHGIESENFVPPERTMGAIGG
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA