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The map label for this gene is pyrH

Identifier: 54026100

GI number: 54026100

Start: 4276938

End: 4277666

Strand: Reverse

Name: pyrH

Synonym: nfa41290

Alternate gene names: 54026100

Gene position: 4277666-4276938 (Counterclockwise)

Preceding gene: 54026101

Following gene: 54026099

Centisome position: 71.04

GC content: 64.61

Gene sequence:

>729_bases
ATGACGGACCCGGGTACCGACCGTCCAGGATATCGCCGGGTACTTCTCAAACTGGGTGGTGAAATGTTCGGCGGCGGCAA
GGTCGGACTCGATCCCGACGTCGTCGAAACGGTCGCCGAGCAGATCGCCGAGGTGGTCGCCGGCGGGGTGCAGGTGGCCG
TGGTGATCGGCGGCGGCAACTTCTTCCGCGGCGCCGAACTCGAGGAACGCGGTATGGAGCGGGCCCGCTCGGACTACATG
GGCATGCTCGGCACCGTCATGAACAGCCTTGCGCTGCAAGACTTCCTGCAGAAGCAAGGGGTGGACACCCGGGTGCAGAC
GGCCATCACGATGGGTCAGGTGGCCGAGCCGTATCTGCCGTTGCGCGCCAAGCGGCACCTGGAGAAGGGCCGCGTGGTGA
TCTTCGGCGCGGGCATGGGTATGCCGTACTTCTCCACCGACACCACCGCCGCGCAGCGCGCCCTCGAGATCGGCGCCGAC
GTGGTGCTGATGGCCAAGGCGGTGGACGGTGTGTTCGACGCCGATCCGCGCGTGGTGCAGACCGCCACGATGTACACCGA
GATCACCCACAAAGAGGTGATCGAGCGCGGCCTCAAGGTCGCCGATGCGACGGCCTTCAGTCTGTGTATGGACAACCAGA
TGCCCATCCTGGTGTTCAATTTGTTGACGAAGGGCAATATCGCCCGAGCGGTCGCCGGTGAGAAGATCGGCACATTGGTT
CGTTCCTGA

Upstream 100 bases:

>100_bases
GAGGAGGCTTTGTTGGGCGGCTTGCGAGCCTGCCGGAAGGTCACCGACCGATGGCTCACACAGGTGGGCAGACCCCGATC
ACCGAAGGAGAAGAGCACCG

Downstream 100 bases:

>100_bases
GCCCGCGACTTGCGGATCATGACGATGACGACGCTGTGGAGGAAATGGTCGTGATTGAAGAAGCGCTCTTCGACGCCGAG
GAGAAGATGGAGAAGGCCGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTDPGTDRPGYRRVLLKLGGEMFGGGKVGLDPDVVETVAEQIAEVVAGGVQVAVVIGGGNFFRGAELEERGMERARSDYM
GMLGTVMNSLALQDFLQKQGVDTRVQTAITMGQVAEPYLPLRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIGAD
VVLMAKAVDGVFDADPRVVQTATMYTEITHKEVIERGLKVADATAFSLCMDNQMPILVFNLLTKGNIARAVAGEKIGTLV
RS

Sequences:

>Translated_242_residues
MTDPGTDRPGYRRVLLKLGGEMFGGGKVGLDPDVVETVAEQIAEVVAGGVQVAVVIGGGNFFRGAELEERGMERARSDYM
GMLGTVMNSLALQDFLQKQGVDTRVQTAITMGQVAEPYLPLRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIGAD
VVLMAKAVDGVFDADPRVVQTATMYTEITHKEVIERGLKVADATAFSLCMDNQMPILVFNLLTKGNIARAVAGEKIGTLV
RS
>Mature_241_residues
TDPGTDRPGYRRVLLKLGGEMFGGGKVGLDPDVVETVAEQIAEVVAGGVQVAVVIGGGNFFRGAELEERGMERARSDYMG
MLGTVMNSLALQDFLQKQGVDTRVQTAITMGQVAEPYLPLRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIGADV
VLMAKAVDGVFDADPRVVQTATMYTEITHKEVIERGLKVADATAFSLCMDNQMPILVFNLLTKGNIARAVAGEKIGTLVR
S

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=49.1452991452991, Blast_Score=218, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_NOCFA (Q5YS63)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120342.1
- HSSP:   P65938
- ProteinModelPortal:   Q5YS63
- SMR:   Q5YS63
- GeneID:   3111431
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa41290
- NMPDR:   fig|247156.1.peg.3986
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   NFAR247156:NFA41290-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25955; Mature: 25824

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: BINDING 58-58 BINDING 59-59 BINDING 63-63 BINDING 78-78 BINDING 172-172 BINDING 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPGTDRPGYRRVLLKLGGEMFGGGKVGLDPDVVETVAEQIAEVVAGGVQVAVVIGGGN
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCC
FFRGAELEERGMERARSDYMGMLGTVMNSLALQDFLQKQGVDTRVQTAITMGQVAEPYLP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
LRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIGADVVLMAKAVDGVFDADPRVVQ
HHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHCCCCCCCCCHHH
TATMYTEITHKEVIERGLKVADATAFSLCMDNQMPILVFNLLTKGNIARAVAGEKIGTLV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHEEHHCCCCHHHHHHHHHHHHHH
RS
CC
>Mature Secondary Structure 
TDPGTDRPGYRRVLLKLGGEMFGGGKVGLDPDVVETVAEQIAEVVAGGVQVAVVIGGGN
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCC
FFRGAELEERGMERARSDYMGMLGTVMNSLALQDFLQKQGVDTRVQTAITMGQVAEPYLP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
LRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIGADVVLMAKAVDGVFDADPRVVQ
HHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHCCCCCCCCCHHH
TATMYTEITHKEVIERGLKVADATAFSLCMDNQMPILVFNLLTKGNIARAVAGEKIGTLV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHEEHHCCCCHHHHHHHHHHHHHH
RS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA