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The map label for this gene is hmp [H]

Identifier: 54026070

GI number: 54026070

Start: 4251076

End: 4252158

Strand: Reverse

Name: hmp [H]

Synonym: nfa40990

Alternate gene names: 54026070

Gene position: 4252158-4251076 (Counterclockwise)

Preceding gene: 54026071

Following gene: 54026069

Centisome position: 70.62

GC content: 71.19

Gene sequence:

>1083_bases
ATGACCGCGGAGACCAGTGTCGGCCTCAGGGCTGCCGGGGGCCCGGCTGCGCCGGATTCGCGCGCACGCGTGGTTCGCGT
GGTCGAGGTGATCGACGAAACCGCCGATGCGCGGTCGTTCGTCGTGGAGCCGCGTGCGGACCACGCCGCGGCCTTCGGCT
ACCGGCCCGGTCAGTTCCTGACGGTCCGGGTGCCGGACGTGGGCAGCGGGTCGGGGCGCTGCTACTCGCTGGCGAGTTCG
CCGCACAGCGACACCGCCATGAAGTTCACCGTGAAGCGGGTCGAGGGCGGCCACGGCTCCAACTGGCTGTGTGACACCGT
CGCCGCGGGCGACGAACTCGAGGTGCTGCCACCGGCGGGCACCTTCACGCCGCGCTCGCTGGACGAGTCGGTGGTGCTGG
TGGCCGGGGGCAGCGGCATCACCCCGGTCATCGCGATCGCCAAATCGATCCTGTTCGGCGGTGCCGGCGAGGTCGTGCTG
ATCTACGCCAACCGGGACGAGGCCTCGGTGATCTTCGCCGCGGAACTGCGCGCGCTCGAGGCCCGCTTCGGTGACCGGTT
CACGGTGATCCACGTGCTCGAGTCGGTGCAGGGCTACCCGTCCCGCCGGTTGTTGTCGACCCTGCTGCGGCCCTTCCTCG
ACCGCAGCGTCTTCCTCTGCGGACCGGCCCCGCTGATGGACCTCACCGCGCAGGTGTGCGCGACGCTCGGATTCCCCGAG
GCCCGAGTGCATTCCGAACGGTTCCTGTCGTTGCAGGCCGACCCGTTCGCCGCCGACACCGAACCCGCCGACGGAAGCGA
CGGCGGCGAGGTGGTGTGCCAGGTGGACGTCGCCATCGACGGGGACGAGCGCCGGGTGCCGTGGGCGGCCGGGCGCACCC
TGCTCGACGCGCTGCTCGCCGCGGGGGTGGACGCGCCGTACTCGTGCCGGGAAGGTGCCTGCAGCGCCTGCGTGTGCACG
TTGAAATCCGGCCGGGTCCGGTTGGCGCACAACGAGATCCTCACCGAGGACGACCTCGCCGACGGCTACATCCTGGCCTG
CCAGGCCGAGCCCGTCACCGACGAGATCGCCATCGAGTACTGA

Upstream 100 bases:

>100_bases
CGAGCGGGCTCAGCCGCCCCCCTGACCGCCGTAGCCTTCCCGCATCCCGGGCCTGATCCACACGCCCCGGGTTGCGATTC
GAGAGGGCTCAGGAGGGCGG

Downstream 100 bases:

>100_bases
ACGCCCCGAGTACTGACAGCAACCCATCGTCCCCCATCTCCGGCACGTCACCGGCGGTCGGTTCGGAAAGGAAACACGAG
CAACCATGACCGAAATCAAA

Product: putative oxidoreductase

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTAETSVGLRAAGGPAAPDSRARVVRVVEVIDETADARSFVVEPRADHAAAFGYRPGQFLTVRVPDVGSGSGRCYSLASS
PHSDTAMKFTVKRVEGGHGSNWLCDTVAAGDELEVLPPAGTFTPRSLDESVVLVAGGSGITPVIAIAKSILFGGAGEVVL
IYANRDEASVIFAAELRALEARFGDRFTVIHVLESVQGYPSRRLLSTLLRPFLDRSVFLCGPAPLMDLTAQVCATLGFPE
ARVHSERFLSLQADPFAADTEPADGSDGGEVVCQVDVAIDGDERRVPWAAGRTLLDALLAAGVDAPYSCREGACSACVCT
LKSGRVRLAHNEILTEDDLADGYILACQAEPVTDEIAIEY

Sequences:

>Translated_360_residues
MTAETSVGLRAAGGPAAPDSRARVVRVVEVIDETADARSFVVEPRADHAAAFGYRPGQFLTVRVPDVGSGSGRCYSLASS
PHSDTAMKFTVKRVEGGHGSNWLCDTVAAGDELEVLPPAGTFTPRSLDESVVLVAGGSGITPVIAIAKSILFGGAGEVVL
IYANRDEASVIFAAELRALEARFGDRFTVIHVLESVQGYPSRRLLSTLLRPFLDRSVFLCGPAPLMDLTAQVCATLGFPE
ARVHSERFLSLQADPFAADTEPADGSDGGEVVCQVDVAIDGDERRVPWAAGRTLLDALLAAGVDAPYSCREGACSACVCT
LKSGRVRLAHNEILTEDDLADGYILACQAEPVTDEIAIEY
>Mature_359_residues
TAETSVGLRAAGGPAAPDSRARVVRVVEVIDETADARSFVVEPRADHAAAFGYRPGQFLTVRVPDVGSGSGRCYSLASSP
HSDTAMKFTVKRVEGGHGSNWLCDTVAAGDELEVLPPAGTFTPRSLDESVVLVAGGSGITPVIAIAKSILFGGAGEVVLI
YANRDEASVIFAAELRALEARFGDRFTVIHVLESVQGYPSRRLLSTLLRPFLDRSVFLCGPAPLMDLTAQVCATLGFPEA
RVHSERFLSLQADPFAADTEPADGSDGGEVVCQVDVAIDGDERRVPWAAGRTLLDALLAAGVDAPYSCREGACSACVCTL
KSGRVRLAHNEILTEDDLADGYILACQAEPVTDEIAIEY

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1787658, Length=350, Percent_Identity=30.8571428571429, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1787098, Length=310, Percent_Identity=30.3225806451613, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788903, Length=242, Percent_Identity=32.2314049586777, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37995; Mature: 37864

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAETSVGLRAAGGPAAPDSRARVVRVVEVIDETADARSFVVEPRADHAAAFGYRPGQFL
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCCCCEE
TVRVPDVGSGSGRCYSLASSPHSDTAMKFTVKRVEGGHGSNWLCDTVAAGDELEVLPPAG
EEECCCCCCCCCCEEEECCCCCCCCEEEEEEEEECCCCCCCCEEHHHCCCCCEEEECCCC
TFTPRSLDESVVLVAGGSGITPVIAIAKSILFGGAGEVVLIYANRDEASVIFAAELRALE
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEHHHHHHHH
ARFGDRFTVIHVLESVQGYPSRRLLSTLLRPFLDRSVFLCGPAPLMDLTAQVCATLGFPE
HHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCH
ARVHSERFLSLQADPFAADTEPADGSDGGEVVCQVDVAIDGDERRVPWAAGRTLLDALLA
HHHCHHHEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHH
AGVDAPYSCREGACSACVCTLKSGRVRLAHNEILTEDDLADGYILACQAEPVTDEIAIEY
HCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TAETSVGLRAAGGPAAPDSRARVVRVVEVIDETADARSFVVEPRADHAAAFGYRPGQFL
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCCCCEE
TVRVPDVGSGSGRCYSLASSPHSDTAMKFTVKRVEGGHGSNWLCDTVAAGDELEVLPPAG
EEECCCCCCCCCCEEEECCCCCCCCEEEEEEEEECCCCCCCCEEHHHCCCCCEEEECCCC
TFTPRSLDESVVLVAGGSGITPVIAIAKSILFGGAGEVVLIYANRDEASVIFAAELRALE
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEHHHHHHHH
ARFGDRFTVIHVLESVQGYPSRRLLSTLLRPFLDRSVFLCGPAPLMDLTAQVCATLGFPE
HHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCH
ARVHSERFLSLQADPFAADTEPADGSDGGEVVCQVDVAIDGDERRVPWAAGRTLLDALLA
HHHCHHHEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHH
AGVDAPYSCREGACSACVCTLKSGRVRLAHNEILTEDDLADGYILACQAEPVTDEIAIEY
HCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]