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The map label for this gene is hsaC [H]

Identifier: 54026069

GI number: 54026069

Start: 4250037

End: 4250990

Strand: Reverse

Name: hsaC [H]

Synonym: nfa40980

Alternate gene names: 54026069

Gene position: 4250990-4250037 (Counterclockwise)

Preceding gene: 54026070

Following gene: 54026068

Centisome position: 70.6

GC content: 69.08

Gene sequence:

>954_bases
ATGACCGAAATCAAAGGACTCGGCTACGTCCGGGTGTACGCCACCGACATGGAGCGCTGGCGCGAACTCGGTTTCGAGGT
GTTGGGTTTCGCCCCCGGCTTCGGCGTCGAGGAGGACGCCCTGCACTTCCGGATGGACGAGCGCCCCGCGCGCATCACCG
TCGAACACGGTGAGGTGGACCGGGTGACCGCCGTCGGCTGGGAGGTGCGGGACGCGCCCGCGCTGCGCAGGCTGGCGGCC
ACCCTGGAGGCCGCGGGGGTGGAATACACCGAGATGTCGCAGGAACTGGCCGATCGCCGCAAGGTCGAGGCGGGTATCTG
CGCCAAGGACCCCGGCGGCACACCGCTGGAGTTCTTCTACGGGCCCGTGCTCGAACACAGCCCGGTGCTGACCAAGTGGG
GCCAGCGTTTCGTCACCGGCGAGCAGGGCCTCGGCCATGTGGTGATGCCCACGACCAACTTCGACGAGTCGTTCGCCTTC
TACACCGAGACGCTGGGCTTCCTCGCGCGCGGGGCGTTCCGGATGCCGTCGCCGCCGGACGCGCCGCCGCAGCGGATCCG
GTTCCTCGGCGTCAACCAGCGCCACCACAGTCTGGCCATCATGCCGAGCCTGGAGGGCCGCGACCCCGGCCTGATCCACG
TGATGGTCGAGGTCGACGAACTGGACGCGGTCGGCCGCGCCTACGACCAGGTGATGGCGCGCGACTTCCCGGTGTCCTCG
ACGCTGGGCCGCCACACCAACGACAAGATGATCTCCTTCTACGTCCGGGTGCCCGGCGGCTGGGACATCGAGTACGGCAC
CGGCGGCAAGCTCGTCGACGAGACCTACTACACCGCCGAGGAGATCACCGCCGACAGCTACTGGGGCCACGAGTGGATGT
GGATGCGGGAGATGAAGCAGGCGCAGCAGGAGGCCGCCGCGCAGACCGCCGAGCCGCGGGAAGTGGCGTCGTGA

Upstream 100 bases:

>100_bases
GCCATCGAGTACTGAACGCCCCGAGTACTGACAGCAACCCATCGTCCCCCATCTCCGGCACGTCACCGGCGGTCGGTTCG
GAAAGGAAACACGAGCAACC

Downstream 100 bases:

>100_bases
GCACCGAATTCGATGCCGTGGTGGTCGGAGCCGGGATCTCGGGCCTGTACGCGGTGTACAAACTGCGGCAGCGCGGGATG
CGGGTGCGGGGCTTCGAGTC

Product: putative ring-cleavage dioxygenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTEIKGLGYVRVYATDMERWRELGFEVLGFAPGFGVEEDALHFRMDERPARITVEHGEVDRVTAVGWEVRDAPALRRLAA
TLEAAGVEYTEMSQELADRRKVEAGICAKDPGGTPLEFFYGPVLEHSPVLTKWGQRFVTGEQGLGHVVMPTTNFDESFAF
YTETLGFLARGAFRMPSPPDAPPQRIRFLGVNQRHHSLAIMPSLEGRDPGLIHVMVEVDELDAVGRAYDQVMARDFPVSS
TLGRHTNDKMISFYVRVPGGWDIEYGTGGKLVDETYYTAEEITADSYWGHEWMWMREMKQAQQEAAAQTAEPREVAS

Sequences:

>Translated_317_residues
MTEIKGLGYVRVYATDMERWRELGFEVLGFAPGFGVEEDALHFRMDERPARITVEHGEVDRVTAVGWEVRDAPALRRLAA
TLEAAGVEYTEMSQELADRRKVEAGICAKDPGGTPLEFFYGPVLEHSPVLTKWGQRFVTGEQGLGHVVMPTTNFDESFAF
YTETLGFLARGAFRMPSPPDAPPQRIRFLGVNQRHHSLAIMPSLEGRDPGLIHVMVEVDELDAVGRAYDQVMARDFPVSS
TLGRHTNDKMISFYVRVPGGWDIEYGTGGKLVDETYYTAEEITADSYWGHEWMWMREMKQAQQEAAAQTAEPREVAS
>Mature_316_residues
TEIKGLGYVRVYATDMERWRELGFEVLGFAPGFGVEEDALHFRMDERPARITVEHGEVDRVTAVGWEVRDAPALRRLAAT
LEAAGVEYTEMSQELADRRKVEAGICAKDPGGTPLEFFYGPVLEHSPVLTKWGQRFVTGEQGLGHVVMPTTNFDESFAFY
TETLGFLARGAFRMPSPPDAPPQRIRFLGVNQRHHSLAIMPSLEGRDPGLIHVMVEVDELDAVGRAYDQVMARDFPVSST
LGRHTNDKMISFYVRVPGGWDIEYGTGGKLVDETYYTAEEITADSYWGHEWMWMREMKQAQQEAAAQTAEPREVAS

Specific function: Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4- oic acid (4,9-DSHA) [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the extradiol ring-cleavage dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR000486 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: NA

Molecular weight: Translated: 35640; Mature: 35508

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIKGLGYVRVYATDMERWRELGFEVLGFAPGFGVEEDALHFRMDERPARITVEHGEVD
CCCCCCCCEEEEEEHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCCCEEEEECCCCC
RVTAVGWEVRDAPALRRLAATLEAAGVEYTEMSQELADRRKVEAGICAKDPGGTPLEFFY
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GPVLEHSPVLTKWGQRFVTGEQGLGHVVMPTTNFDESFAFYTETLGFLARGAFRMPSPPD
CCHHCCCCHHHHHHHEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
APPQRIRFLGVNQRHHSLAIMPSLEGRDPGLIHVMVEVDELDAVGRAYDQVMARDFPVSS
CCHHHEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCHH
TLGRHTNDKMISFYVRVPGGWDIEYGTGGKLVDETYYTAEEITADSYWGHEWMWMREMKQ
HHCCCCCCCEEEEEEECCCCEEEEECCCCCEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
AQQEAAAQTAEPREVAS
HHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
TEIKGLGYVRVYATDMERWRELGFEVLGFAPGFGVEEDALHFRMDERPARITVEHGEVD
CCCCCCCEEEEEEHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCCCEEEEECCCCC
RVTAVGWEVRDAPALRRLAATLEAAGVEYTEMSQELADRRKVEAGICAKDPGGTPLEFFY
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GPVLEHSPVLTKWGQRFVTGEQGLGHVVMPTTNFDESFAFYTETLGFLARGAFRMPSPPD
CCHHCCCCHHHHHHHEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
APPQRIRFLGVNQRHHSLAIMPSLEGRDPGLIHVMVEVDELDAVGRAYDQVMARDFPVSS
CCHHHEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCHH
TLGRHTNDKMISFYVRVPGGWDIEYGTGGKLVDETYYTAEEITADSYWGHEWMWMREMKQ
HHCCCCCCCEEEEEEECCCCEEEEECCCCCEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
AQQEAAAQTAEPREVAS
HHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]