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The map label for this gene is kstD [H]

Identifier: 54026062

GI number: 54026062

Start: 4243496

End: 4245202

Strand: Reverse

Name: kstD [H]

Synonym: nfa40910

Alternate gene names: 54026062

Gene position: 4245202-4243496 (Counterclockwise)

Preceding gene: 54026065

Following gene: 54026060

Centisome position: 70.5

GC content: 71.88

Gene sequence:

>1707_bases
ATGGTGAACAAGACGATGCCCCCGCGCACGCCCGCCCACGATGTGACCGTCGATCTGCTGGTCGTCGGCTCGGGCACGGG
CATGGCGGCCGCGCTGGCCGCACACGAACTCGGACTCTCGGTCGTCATCGCCGAGAAGACCGCCCACGTGGGCGGTTCCA
CCGCGCGTTCGGGCGGTGCGTTCTGGATTCCGGGCAGCTCGATACTGCCCGACCAGGGCGCGCAGGCGCTGGCGGAGGCG
GGCACGTATGTCCGGTCGGTGGTCGGTGATTCGGCGCCCCCCGAGCGCGGTCAGGCGTTCCTGGACAACGGCCCCGCGGC
GGTCGCCATGCTGGAGCGCACCACCCCGATGCGGTTCTTCTGGGCCGAGGGCTATTCGGACTACCACCCCGAGCAGCCCG
GCGGCCGCGCGGAAGGCCGCACCTGCGAATGCCGTCCGTTCGACGCCTCCGTCCTCGGCGCGGAACGGCCCCGGCTGCGG
CCCGGCGTCATGGAGGCGCCGGTGCCGATGCCGGTCACCGGCGCCGACTACAAGTGGATGAATCTGCTGGCGCGCAAACC
GCTGAAGGCGCTGCCGCGCATCGTCAAACGCGCCTCCCTCGGCCTCGGCGGCATGCTGATCGGCCGGGAGTACATGGCCG
GCGGTCAGGCGCTCGCGGCCGGCCTGTTCGCCGGTGTGCTGCGCGCGGGCATCCCGGTCTGGACCGAGACCAGCCTGGTG
CGCCTGGTCATGATCGGCGACCGGGTGACCGGTGCCGTGCTGGTGCAGGGCGACCGCGAGGTCACCGTGACAGCCCGCCG
CGGTGTCGTCCTCGCCGCGGGCGGCTTCGACCACGACATGGCGGCCCGCCGCAAGTACCAGTCCCCGGCGCTGCCCGAAC
ACGCCAGCCTCGGCGCGGAAGGCAACACCGGTGACGCCATCGAGGCCGCCCAGCAACTCGGCGCGGGCATCGCGTCGATG
GATCAGGCGTGGTGGTTCCCGGCGTTCGCGCCGCTGCCCGGCGCCGCGCCCGCGGTGATGCTCGCCGAGCGTTCGCTGCC
CGGCTCGTTCATCGTCGACCAGACCGGCAAGCGGTTCGTCAACGAGGCCGTCGACTACATGTCCTTCGGCCAGCAGATGC
TGGCCAGGGAACGCGCGGGCGACCCGGTCACCGACATGTGGCTGGTGTTCGATCAGCGCTACCGCAACAGCTACATCCTG
GCCGGGCAGTTCTACCCGCGCCAGCCGCTGGCGAAGTCCTGGTACGAGGCGGGCATCGCGCACAAGGCGGCCGATCCGGC
CGCGCTGGCCCGGGCGATGGGGGTGCCCGAGGAGACCTTCACCGCCACCTTCCGGCAGTTCAACGACCTCGCCGGAACGG
GTGTGGACACCGAATTCGACCGCGGCGCCAGCGCGTACGACCGCTACTACGGCGACCCGACGGTGTCGCCGAACCCGAAC
CTGGCCGCGCTGGCCAAGGCCCCGTACTACGCGGTGAAGATGATCCTCAGCGATCTGGGCACCTGCGGCGGCGTCGTCGC
CGACGAACACGCGCGGGTCCTGCGCGAGGACGGCAGCGCCATCGACGGCCTCTACGCGATCGGCAACACCGCCGCCAACG
CCTTCGGCGCCACCTACCCCGGTGCGGGCGCGACCATCGGCCAGGGACTCGTCTACGGCTACATCGCGGCCCAGCACGCG
GCACAGACGCGCGGGGACGGCGGATAG

Upstream 100 bases:

>100_bases
GAATGGACACGCGCGGCGGCGGCGCGCCCGCGACGTTCTACGTTACGTCCACTCGCGTCCCGACCCCCGGAGTGGAGTCC
GAACTGATGGTGAACAACTG

Downstream 100 bases:

>100_bases
ATACCGGCTGCGCCGCCCCCGAGCGACAAGGCCCGCCACCGGATCCGGTGGCGGGCCTTTCTACGGTGCGTTCGGTTGCC
GGGGACGGCGATCACATGTG

Product: 3-ketosteroid-delta-1-dehydrogenase

Products: NA

Alternate protein names: 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD [H]

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MVNKTMPPRTPAHDVTVDLLVVGSGTGMAAALAAHELGLSVVIAEKTAHVGGSTARSGGAFWIPGSSILPDQGAQALAEA
GTYVRSVVGDSAPPERGQAFLDNGPAAVAMLERTTPMRFFWAEGYSDYHPEQPGGRAEGRTCECRPFDASVLGAERPRLR
PGVMEAPVPMPVTGADYKWMNLLARKPLKALPRIVKRASLGLGGMLIGREYMAGGQALAAGLFAGVLRAGIPVWTETSLV
RLVMIGDRVTGAVLVQGDREVTVTARRGVVLAAGGFDHDMAARRKYQSPALPEHASLGAEGNTGDAIEAAQQLGAGIASM
DQAWWFPAFAPLPGAAPAVMLAERSLPGSFIVDQTGKRFVNEAVDYMSFGQQMLARERAGDPVTDMWLVFDQRYRNSYIL
AGQFYPRQPLAKSWYEAGIAHKAADPAALARAMGVPEETFTATFRQFNDLAGTGVDTEFDRGASAYDRYYGDPTVSPNPN
LAALAKAPYYAVKMILSDLGTCGGVVADEHARVLREDGSAIDGLYAIGNTAANAFGATYPGAGATIGQGLVYGYIAAQHA
AQTRGDGG

Sequences:

>Translated_568_residues
MVNKTMPPRTPAHDVTVDLLVVGSGTGMAAALAAHELGLSVVIAEKTAHVGGSTARSGGAFWIPGSSILPDQGAQALAEA
GTYVRSVVGDSAPPERGQAFLDNGPAAVAMLERTTPMRFFWAEGYSDYHPEQPGGRAEGRTCECRPFDASVLGAERPRLR
PGVMEAPVPMPVTGADYKWMNLLARKPLKALPRIVKRASLGLGGMLIGREYMAGGQALAAGLFAGVLRAGIPVWTETSLV
RLVMIGDRVTGAVLVQGDREVTVTARRGVVLAAGGFDHDMAARRKYQSPALPEHASLGAEGNTGDAIEAAQQLGAGIASM
DQAWWFPAFAPLPGAAPAVMLAERSLPGSFIVDQTGKRFVNEAVDYMSFGQQMLARERAGDPVTDMWLVFDQRYRNSYIL
AGQFYPRQPLAKSWYEAGIAHKAADPAALARAMGVPEETFTATFRQFNDLAGTGVDTEFDRGASAYDRYYGDPTVSPNPN
LAALAKAPYYAVKMILSDLGTCGGVVADEHARVLREDGSAIDGLYAIGNTAANAFGATYPGAGATIGQGLVYGYIAAQHA
AQTRGDGG
>Mature_568_residues
MVNKTMPPRTPAHDVTVDLLVVGSGTGMAAALAAHELGLSVVIAEKTAHVGGSTARSGGAFWIPGSSILPDQGAQALAEA
GTYVRSVVGDSAPPERGQAFLDNGPAAVAMLERTTPMRFFWAEGYSDYHPEQPGGRAEGRTCECRPFDASVLGAERPRLR
PGVMEAPVPMPVTGADYKWMNLLARKPLKALPRIVKRASLGLGGMLIGREYMAGGQALAAGLFAGVLRAGIPVWTETSLV
RLVMIGDRVTGAVLVQGDREVTVTARRGVVLAAGGFDHDMAARRKYQSPALPEHASLGAEGNTGDAIEAAQQLGAGIASM
DQAWWFPAFAPLPGAAPAVMLAERSLPGSFIVDQTGKRFVNEAVDYMSFGQQMLARERAGDPVTDMWLVFDQRYRNSYIL
AGQFYPRQPLAKSWYEAGIAHKAADPAALARAMGVPEETFTATFRQFNDLAGTGVDTEFDRGASAYDRYYGDPTVSPNPN
LAALAKAPYYAVKMILSDLGTCGGVVADEHARVLREDGSAIDGLYAIGNTAANAFGATYPGAGATIGQGLVYGYIAAQHA
AQTRGDGG

Specific function: Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids. Is also involved in the formation of 3-keto-1,4- diene-steroid from 3-keto-4-ene-steroid [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI71986328, Length=352, Percent_Identity=24.7159090909091, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.3.99.4 [H]

Molecular weight: Translated: 59835; Mature: 59835

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNKTMPPRTPAHDVTVDLLVVGSGTGMAAALAAHELGLSVVIAEKTAHVGGSTARSGGA
CCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCEEEEEEECHHCCCCCCCCCCCE
FWIPGSSILPDQGAQALAEAGTYVRSVVGDSAPPERGQAFLDNGPAAVAMLERTTPMRFF
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCEECCCCCEEEEEEECCCCEEEE
WAEGYSDYHPEQPGGRAEGRTCECRPFDASVLGAERPRLRPGVMEAPVPMPVTGADYKWM
EECCCCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
NLLARKPLKALPRIVKRASLGLGGMLIGREYMAGGQALAAGLFAGVLRAGIPVWTETSLV
HHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEE
RLVMIGDRVTGAVLVQGDREVTVTARRGVVLAAGGFDHDMAARRKYQSPALPEHASLGAE
EEEEECCCCCEEEEEECCCEEEEEEECCEEEEECCCCHHHHHHHHCCCCCCCCHHCCCCC
GNTGDAIEAAQQLGAGIASMDQAWWFPAFAPLPGAAPAVMLAERSLPGSFIVDQTGKRFV
CCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEECHHHHHHH
NEAVDYMSFGQQMLARERAGDPVTDMWLVFDQRYRNSYILAGQFYPRQPLAKSWYEAGIA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHH
HKAADPAALARAMGVPEETFTATFRQFNDLAGTGVDTEFDRGASAYDRYYGDPTVSPNPN
HCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
LAALAKAPYYAVKMILSDLGTCGGVVADEHARVLREDGSAIDGLYAIGNTAANAFGATYP
EEEEHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCCCC
GAGATIGQGLVYGYIAAQHAAQTRGDGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVNKTMPPRTPAHDVTVDLLVVGSGTGMAAALAAHELGLSVVIAEKTAHVGGSTARSGGA
CCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCEEEEEEECHHCCCCCCCCCCCE
FWIPGSSILPDQGAQALAEAGTYVRSVVGDSAPPERGQAFLDNGPAAVAMLERTTPMRFF
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCEECCCCCEEEEEEECCCCEEEE
WAEGYSDYHPEQPGGRAEGRTCECRPFDASVLGAERPRLRPGVMEAPVPMPVTGADYKWM
EECCCCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
NLLARKPLKALPRIVKRASLGLGGMLIGREYMAGGQALAAGLFAGVLRAGIPVWTETSLV
HHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEE
RLVMIGDRVTGAVLVQGDREVTVTARRGVVLAAGGFDHDMAARRKYQSPALPEHASLGAE
EEEEECCCCCEEEEEECCCEEEEEEECCEEEEECCCCHHHHHHHHCCCCCCCCHHCCCCC
GNTGDAIEAAQQLGAGIASMDQAWWFPAFAPLPGAAPAVMLAERSLPGSFIVDQTGKRFV
CCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEECHHHHHHH
NEAVDYMSFGQQMLARERAGDPVTDMWLVFDQRYRNSYILAGQFYPRQPLAKSWYEAGIA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHH
HKAADPAALARAMGVPEETFTATFRQFNDLAGTGVDTEFDRGASAYDRYYGDPTVSPNPN
HCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
LAALAKAPYYAVKMILSDLGTCGGVVADEHARVLREDGSAIDGLYAIGNTAANAFGATYP
EEEEHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCCCC
GAGATIGQGLVYGYIAAQHAAQTRGDGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12218036 [H]