Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 54026060

GI number: 54026060

Start: 4241566

End: 4242429

Strand: Reverse

Name: map [H]

Synonym: nfa40890

Alternate gene names: 54026060

Gene position: 4242429-4241566 (Counterclockwise)

Preceding gene: 54026062

Following gene: 54026059

Centisome position: 70.46

GC content: 67.25

Gene sequence:

>864_bases
ATGTCCGTGCGCACTCGTCAGCCCCTCGTTCCCGGCACACCGACCCCGATCCGGGAGGTGCCGCGCTCCATCGAGCGACC
GGAGTACGCGTGGAAGAAGACCGCGAAAGAGGGCAGCGAACCGTGGGTGCAGACCCCGGAGACCATCGAGAAGATGCGGA
TCGCCTGCCGCATCGCCGCGCAGGCGCTGGAGGAGGCCGGTAAGGCCGTCGCACCGGGGGTCACCACCGACGAACTGGAC
CGGATCGCGCACGAGTACATGTGCGATCACGGCGCCTACCCGTCCACGCTCGGCTACAAGGGCTTCCCGAAGTCCTGCTG
CACCTCGTTGAACGAGGTGATCTGCCACGGCATCCCGGATTCGACGGTCATCCAGGACGGCGACATCGTCAACATCGACG
TCACCGCCTACATCCACGGCGTGCACGGCGACACCAACAAGACCTTCCTGGCCGGCGACGTCGACGAGGAGGTCCGGCTG
CTGGTCGAGCGCACCGAGGAGGCCACCAACCGGGCCATCAAGGCGGTGCGGCCGGGCCGGGCGCTCAACGTCATCGGGCG
GGTCATCGAGGCCTACGCCAACCGTTTCGGCTACGGCGTGGTGCGCGACTTCACCGGGCACGGCGTCGGCCCCACCTTCC
ACAACGGCCTGGTGATCCTGCACTACGACCAGCCCGCGGTGGAGACCGTCATCGAGCCCGGGATGACCTTCACCATCGAG
CCGATGATCAACCTCGGCGGCATCGACTACGAGATCTGGGACGACGGCTGGACCGTGGTGACCAAGGACCGCAAGTGGAC
CGCGCAGTTCGAGCACACGCTGGTCGTCACCGAGACCGGCGCGGAAGTGCTCACCCTGCCGTGA

Upstream 100 bases:

>100_bases
CCGCGCCACCTGGTCGGGAGTACACGGGTGTCTCACTCAGCGGGTCGCCGCGGCGCCTTCCCGCGGTCGTCACCACCGCC
GCTGCCGATAGGCTGTCGGC

Downstream 100 bases:

>100_bases
CCGCGGCCGGACACCGCCGGTGAAGGGCGCGCTGCTGGTCGCGGGCACCACCTCCGACGCGGGAAAGAGCGTGGTGGTGG
CCGGGCTGTGCCGGATGCTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSVRTRQPLVPGTPTPIREVPRSIERPEYAWKKTAKEGSEPWVQTPETIEKMRIACRIAAQALEEAGKAVAPGVTTDELD
RIAHEYMCDHGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVIQDGDIVNIDVTAYIHGVHGDTNKTFLAGDVDEEVRL
LVERTEEATNRAIKAVRPGRALNVIGRVIEAYANRFGYGVVRDFTGHGVGPTFHNGLVILHYDQPAVETVIEPGMTFTIE
PMINLGGIDYEIWDDGWTVVTKDRKWTAQFEHTLVVTETGAEVLTLP

Sequences:

>Translated_287_residues
MSVRTRQPLVPGTPTPIREVPRSIERPEYAWKKTAKEGSEPWVQTPETIEKMRIACRIAAQALEEAGKAVAPGVTTDELD
RIAHEYMCDHGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVIQDGDIVNIDVTAYIHGVHGDTNKTFLAGDVDEEVRL
LVERTEEATNRAIKAVRPGRALNVIGRVIEAYANRFGYGVVRDFTGHGVGPTFHNGLVILHYDQPAVETVIEPGMTFTIE
PMINLGGIDYEIWDDGWTVVTKDRKWTAQFEHTLVVTETGAEVLTLP
>Mature_286_residues
SVRTRQPLVPGTPTPIREVPRSIERPEYAWKKTAKEGSEPWVQTPETIEKMRIACRIAAQALEEAGKAVAPGVTTDELDR
IAHEYMCDHGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVIQDGDIVNIDVTAYIHGVHGDTNKTFLAGDVDEEVRLL
VERTEEATNRAIKAVRPGRALNVIGRVIEAYANRFGYGVVRDFTGHGVGPTFHNGLVILHYDQPAVETVIEPGMTFTIEP
MINLGGIDYEIWDDGWTVVTKDRKWTAQFEHTLVVTETGAEVLTLP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=291, Percent_Identity=46.0481099656357, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI40385867, Length=278, Percent_Identity=42.8057553956835, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=49.5934959349593, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788728, Length=250, Percent_Identity=26.8, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=286, Percent_Identity=47.5524475524476, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6323273, Length=279, Percent_Identity=44.8028673835125, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21355531, Length=284, Percent_Identity=48.943661971831, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24583427, Length=284, Percent_Identity=42.9577464788732, Blast_Score=247, Evalue=5e-66,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 31698; Mature: 31567

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRTRQPLVPGTPTPIREVPRSIERPEYAWKKTAKEGSEPWVQTPETIEKMRIACRIAA
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
QALEEAGKAVAPGVTTDELDRIAHEYMCDHGAYPSTLGYKGFPKSCCTSLNEVICHGIPD
HHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
STVIQDGDIVNIDVTAYIHGVHGDTNKTFLAGDVDEEVRLLVERTEEATNRAIKAVRPGR
CCEEECCCEEEEEEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
ALNVIGRVIEAYANRFGYGVVRDFTGHGVGPTFHNGLVILHYDQPAVETVIEPGMTFTIE
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCEEEEE
PMINLGGIDYEIWDDGWTVVTKDRKWTAQFEHTLVVTETGAEVLTLP
ECEECCCCEEEEECCCCEEEECCCEEEEEEEEEEEEEECCCEEEECC
>Mature Secondary Structure 
SVRTRQPLVPGTPTPIREVPRSIERPEYAWKKTAKEGSEPWVQTPETIEKMRIACRIAA
CCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
QALEEAGKAVAPGVTTDELDRIAHEYMCDHGAYPSTLGYKGFPKSCCTSLNEVICHGIPD
HHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
STVIQDGDIVNIDVTAYIHGVHGDTNKTFLAGDVDEEVRLLVERTEEATNRAIKAVRPGR
CCEEECCCEEEEEEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
ALNVIGRVIEAYANRFGYGVVRDFTGHGVGPTFHNGLVILHYDQPAVETVIEPGMTFTIE
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCEEEEE
PMINLGGIDYEIWDDGWTVVTKDRKWTAQFEHTLVVTETGAEVLTLP
ECEECCCCEEEEECCCCEEEECCCEEEEEEEEEEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]