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The map label for this gene is pqqL [C]

Identifier: 54025856

GI number: 54025856

Start: 4098469

End: 4099839

Strand: Reverse

Name: pqqL [C]

Synonym: nfa38860

Alternate gene names: 54025856

Gene position: 4099839-4098469 (Counterclockwise)

Preceding gene: 54025857

Following gene: 54025855

Centisome position: 68.09

GC content: 71.41

Gene sequence:

>1371_bases
GTGAGCAAGAAGAAGACGACGACCCCCCTGATCCCGAGCGGGCAGGGGGGTCCGTCACTACGGCAGCGGGTCGACGAGGC
GGTGGACTCCGGCGTGCGGCGCACCGTGCTGCCCGGCGGCCTGCGGGTGGTGACCGAGCATGTCCCCGGGGTCCGGTCGG
CCTCGATCGGGGTGTGGGTCGGCGTCGGCTCCCGCGACGAGGGCCGCACCGTGGCCGGCGCCGCGCATTTCCTCGAGCAT
CTGCTGTTCAAGGCGACGCCGACCCGGTCGGCGCTCGACATCGCGCAGGCGATGGACGCCGTCGGCGGTGAACTGAACGC
CTTCACCGCCAAGGAGCAGACCTGCTACTACGCGCATGTGCTCGACGAGGACCTGCCGCTGGCGGTGGACATGGTCTCCG
ACGTGGTGCTCAACGGGCTGTGCCGCTCGGCCGACGTGGACGTCGAACGGCAGGTGGTGCTCGAGGAGATCGCCATGCGC
GACGACGACCCCGAGGATCTGGTCGGCGACGCCTTCCTCACCGCGCTGTTCGGCGATCATCCGATCGGCCGGCCGGTGAT
CGGCTCGGTGGAATCCATCGAGTCGATGACCGCCGCCCAGCTGCGTGGCTTCCATCAGCGCCGCTACCGTCCGGACCGGA
TGGTGGTGGCGGTGGCGGGCAATGTCGAGCACGAGCACACCGTCGAACTGGTGCACCGCGCCTTCGAGAACCGGCTCGAT
CCGGCGGCGCAGCCCGCGCCGCGGCGGGAGGGCAGGTTCCGTCCGCACGGCGCGCCGGAATTGCAGTGGAGTTTCCGCGA
CAGCGAGCAGGCGCATCTGGTGTTCGGCGTGCGCGCGTTCGGGCGGCACGAGGGGGAGCGGCGCTGGCCGTTGTCGGTGC
TGAACACGGTGGTCGGCGGCGGGTTGAGTTCGCGGCTGTTCCAGCGCATCCGGGAGGAGCGCGGGCTGGCCTATTCGGTG
TACTCGAGTGTGGACACCTTCGCCGACACCGGCGCGTTCTCGGTGTACATCGGCTGCCAGCCGGAGAACCTGGGCGAGGT
GGCGCGGCTGGCGAAGGGCGTGCTCGAGGAGGTCGCCGAACACGGCGTGACCGACGCCGAATGCGCCCGCGCCAAGGGGT
CGCTGCGCGGCGGGCTGGTGCTGGGTCTGGAGGATTCGGCCTCCCGGATGAACCGGATCGGCCGCAGCGAACTGAGCTAC
GGCAACCACCGCAGCGTCTCGGAGACGCTGGCTCGCATCGATGCCGTCACCACCGAGGAGGTGGCCGCCATCGCGCGCAC
GCTGCTGTCGCGGCCGTTCGGGGTCTCGGTCGCCGGGCCGTACCGGCGCACCCGCGACCTGCCCGCCGCGGTCCGGCGCC
TGGTCGCCTGA

Upstream 100 bases:

>100_bases
TCGACAACCGGGGCAAGATCTCGCTGGTCCCGGTCGACGAGAACGCCGACGAGCCCGCGGCGGATGCCGTCGACGCCGGA
ACCGAGTAGTACTGGTCGGT

Downstream 100 bases:

>100_bases
ACCGGGCGGCCGGACTCCGGGTGGGACGCTCGCTCGCGTGAGATTCCCGGCGTGACCTCTGGGCCGCGTGGTGGTTGCCA
CCCGGGGCGCGCCGGACTCG

Product: putative protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSKKKTTTPLIPSGQGGPSLRQRVDEAVDSGVRRTVLPGGLRVVTEHVPGVRSASIGVWVGVGSRDEGRTVAGAAHFLEH
LLFKATPTRSALDIAQAMDAVGGELNAFTAKEQTCYYAHVLDEDLPLAVDMVSDVVLNGLCRSADVDVERQVVLEEIAMR
DDDPEDLVGDAFLTALFGDHPIGRPVIGSVESIESMTAAQLRGFHQRRYRPDRMVVAVAGNVEHEHTVELVHRAFENRLD
PAAQPAPRREGRFRPHGAPELQWSFRDSEQAHLVFGVRAFGRHEGERRWPLSVLNTVVGGGLSSRLFQRIREERGLAYSV
YSSVDTFADTGAFSVYIGCQPENLGEVARLAKGVLEEVAEHGVTDAECARAKGSLRGGLVLGLEDSASRMNRIGRSELSY
GNHRSVSETLARIDAVTTEEVAAIARTLLSRPFGVSVAGPYRRTRDLPAAVRRLVA

Sequences:

>Translated_456_residues
MSKKKTTTPLIPSGQGGPSLRQRVDEAVDSGVRRTVLPGGLRVVTEHVPGVRSASIGVWVGVGSRDEGRTVAGAAHFLEH
LLFKATPTRSALDIAQAMDAVGGELNAFTAKEQTCYYAHVLDEDLPLAVDMVSDVVLNGLCRSADVDVERQVVLEEIAMR
DDDPEDLVGDAFLTALFGDHPIGRPVIGSVESIESMTAAQLRGFHQRRYRPDRMVVAVAGNVEHEHTVELVHRAFENRLD
PAAQPAPRREGRFRPHGAPELQWSFRDSEQAHLVFGVRAFGRHEGERRWPLSVLNTVVGGGLSSRLFQRIREERGLAYSV
YSSVDTFADTGAFSVYIGCQPENLGEVARLAKGVLEEVAEHGVTDAECARAKGSLRGGLVLGLEDSASRMNRIGRSELSY
GNHRSVSETLARIDAVTTEEVAAIARTLLSRPFGVSVAGPYRRTRDLPAAVRRLVA
>Mature_455_residues
SKKKTTTPLIPSGQGGPSLRQRVDEAVDSGVRRTVLPGGLRVVTEHVPGVRSASIGVWVGVGSRDEGRTVAGAAHFLEHL
LFKATPTRSALDIAQAMDAVGGELNAFTAKEQTCYYAHVLDEDLPLAVDMVSDVVLNGLCRSADVDVERQVVLEEIAMRD
DDPEDLVGDAFLTALFGDHPIGRPVIGSVESIESMTAAQLRGFHQRRYRPDRMVVAVAGNVEHEHTVELVHRAFENRLDP
AAQPAPRREGRFRPHGAPELQWSFRDSEQAHLVFGVRAFGRHEGERRWPLSVLNTVVGGGLSSRLFQRIREERGLAYSVY
SSVDTFADTGAFSVYIGCQPENLGEVARLAKGVLEEVAEHGVTDAECARAKGSLRGGLVLGLEDSASRMNRIGRSELSYG
NHRSVSETLARIDAVTTEEVAAIARTLLSRPFGVSVAGPYRRTRDLPAAVRRLVA

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=433, Percent_Identity=30.0230946882217, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI46593007, Length=415, Percent_Identity=28.6746987951807, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI24308013, Length=454, Percent_Identity=25.9911894273128, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI50592988, Length=418, Percent_Identity=22.7272727272727, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1787770, Length=435, Percent_Identity=21.6091954022989, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999683, Length=407, Percent_Identity=30.4668304668305, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17553678, Length=430, Percent_Identity=29.3023255813954, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323192, Length=438, Percent_Identity=30.8219178082192, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6321813, Length=421, Percent_Identity=22.5653206650831, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357875, Length=426, Percent_Identity=30.5164319248826, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24646943, Length=426, Percent_Identity=30.5164319248826, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI19921772, Length=471, Percent_Identity=24.8407643312102, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49579; Mature: 49447

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKKTTTPLIPSGQGGPSLRQRVDEAVDSGVRRTVLPGGLRVVTEHVPGVRSASIGVWV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEE
GVGSRDEGRTVAGAAHFLEHLLFKATPTRSALDIAQAMDAVGGELNAFTAKEQTCYYAHV
ECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEE
LDEDLPLAVDMVSDVVLNGLCRSADVDVERQVVLEEIAMRDDDPEDLVGDAFLTALFGDH
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PIGRPVIGSVESIESMTAAQLRGFHQRRYRPDRMVVAVAGNVEHEHTVELVHRAFENRLD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCC
PAAQPAPRREGRFRPHGAPELQWSFRDSEQAHLVFGVRAFGRHEGERRWPLSVLNTVVGG
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHCC
GLSSRLFQRIREERGLAYSVYSSVDTFADTGAFSVYIGCQPENLGEVARLAKGVLEEVAE
CHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
HGVTDAECARAKGSLRGGLVLGLEDSASRMNRIGRSELSYGNHRSVSETLARIDAVTTEE
CCCCHHHHHHHCCCCCCCEEEEECHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHH
VAAIARTLLSRPFGVSVAGPYRRTRDLPAAVRRLVA
HHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
SKKKTTTPLIPSGQGGPSLRQRVDEAVDSGVRRTVLPGGLRVVTEHVPGVRSASIGVWV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEE
GVGSRDEGRTVAGAAHFLEHLLFKATPTRSALDIAQAMDAVGGELNAFTAKEQTCYYAHV
ECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEE
LDEDLPLAVDMVSDVVLNGLCRSADVDVERQVVLEEIAMRDDDPEDLVGDAFLTALFGDH
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PIGRPVIGSVESIESMTAAQLRGFHQRRYRPDRMVVAVAGNVEHEHTVELVHRAFENRLD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCC
PAAQPAPRREGRFRPHGAPELQWSFRDSEQAHLVFGVRAFGRHEGERRWPLSVLNTVVGG
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHCC
GLSSRLFQRIREERGLAYSVYSSVDTFADTGAFSVYIGCQPENLGEVARLAKGVLEEVAE
CHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
HGVTDAECARAKGSLRGGLVLGLEDSASRMNRIGRSELSYGNHRSVSETLARIDAVTTEE
CCCCHHHHHHHCCCCCCCEEEEECHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHH
VAAIARTLLSRPFGVSVAGPYRRTRDLPAAVRRLVA
HHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]