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The map label for this gene is hemE

Identifier: 54025708

GI number: 54025708

Start: 3957074

End: 3958138

Strand: Reverse

Name: hemE

Synonym: nfa37380

Alternate gene names: 54025708

Gene position: 3958138-3957074 (Counterclockwise)

Preceding gene: 54025711

Following gene: 54025707

Centisome position: 65.74

GC content: 72.11

Gene sequence:

>1065_bases
ATGGCCGGGATGAGCACTCACACTCGCCGTCGGTTGACCGACGCTCCGTTCCTGGCCGCCGCGACGGGCGCCACCCCCAG
CCGGCGCCCGGTGTGGTTCATGCGCCAGGCGGGCCGCTCGCTGCCCGAGTACCGCGAGCTGCGGGCCGGCATCGGCATGC
TGGAGTCCTGCTTCGACCCCGAGCTGGTCTGCGAGATCACCATGCAGCCGATCCGCCGCCACGGTGTCGACGCGGCGATC
CTGTTCTCCGACATCGTCGTTCCGCTCAAGGCGGCCGGTATCGACCTCGACATCGTCGCCGGGGTCGGTCCGGTGGTGGC
CGCGCCGGTGCGTTCGGTGGCCGACGTGCGCGCGCTGCCGCGACTGCGGCCCGAGGAGGTCGGCGCCGTCGTGGAGGGCG
TGCGGCTGCTGGTGGACGCGCTCGGGCAGACCCCGCTGATCGGTTTCGCCGGCGCACCGTTCACGCTCGCCTCCTACCTG
GTCGAGGGCGGTCCGAGCAAGCATCACGAGCGCACCAAGGCGATGATGTACGCCGACCCGAAGACCTGGCACGAACTGCT
CGGCGTGCTCACCGACATCACCATCGCCTTCCTGCGCGCCCAGCTCGACGCGGGCGTGGACGCGGTGCAGCTGTTCGACT
CGTGGGCGGGCGCGCTGTCGCCGGCCGACTACCGCGCGTTCGTGCTGCCGCATTCGGAGCGGGTGTTCACCGAGATCGCC
GACGCGGGCGTGCCGCGCATCCACTTCGGTGTCGGTACCGGCGAACTGCTCGGTGCGATGGGGGAGGCGGGCGCCGATGT
GGTCGGCGTGGACTGGCGGGTGTCGCTCACCGAGGCGGCCCGGCGGGTCGGTCCGGGAAAGGCGTTGCAGGGCAACCTCG
ATCCCGCGGTCCTGTTCGCCGGTCCGCGGGCCGTCGAGGCGCACGCGCGCCGCATCGCCGAGGAAGCCGACCGGGCATTG
GCGCTGGGCGCGGCCGGACACATCTTCAACCTCGGCCACGGTGTGCTGCCCGACACCGACCCCGGTGTGCTGACCGCGCT
GGTCGAGCTCGTCCACGAACTCTGA

Upstream 100 bases:

>100_bases
CTTCGGTCGGTGCGGCGCCGTCGCGGAAGTCGAGCGGTGTCACGCAGCTGACGGTAGACCGTGCGCACCCGGCGCAGTCG
GAGGCGCGCCGCCGCATACG

Downstream 100 bases:

>100_bases
GACCGGGCCCGAACCCCTGCGCCCGCGAGGGTGCTGAGTCGTTCCCGCCACCGGCCGTGGACCCGCGAGCGGCAGCGCCG
GGGCGCACCGGTGTGTGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAGMSTHTRRRLTDAPFLAAATGATPSRRPVWFMRQAGRSLPEYRELRAGIGMLESCFDPELVCEITMQPIRRHGVDAAI
LFSDIVVPLKAAGIDLDIVAGVGPVVAAPVRSVADVRALPRLRPEEVGAVVEGVRLLVDALGQTPLIGFAGAPFTLASYL
VEGGPSKHHERTKAMMYADPKTWHELLGVLTDITIAFLRAQLDAGVDAVQLFDSWAGALSPADYRAFVLPHSERVFTEIA
DAGVPRIHFGVGTGELLGAMGEAGADVVGVDWRVSLTEAARRVGPGKALQGNLDPAVLFAGPRAVEAHARRIAEEADRAL
ALGAAGHIFNLGHGVLPDTDPGVLTALVELVHEL

Sequences:

>Translated_354_residues
MAGMSTHTRRRLTDAPFLAAATGATPSRRPVWFMRQAGRSLPEYRELRAGIGMLESCFDPELVCEITMQPIRRHGVDAAI
LFSDIVVPLKAAGIDLDIVAGVGPVVAAPVRSVADVRALPRLRPEEVGAVVEGVRLLVDALGQTPLIGFAGAPFTLASYL
VEGGPSKHHERTKAMMYADPKTWHELLGVLTDITIAFLRAQLDAGVDAVQLFDSWAGALSPADYRAFVLPHSERVFTEIA
DAGVPRIHFGVGTGELLGAMGEAGADVVGVDWRVSLTEAARRVGPGKALQGNLDPAVLFAGPRAVEAHARRIAEEADRAL
ALGAAGHIFNLGHGVLPDTDPGVLTALVELVHEL
>Mature_353_residues
AGMSTHTRRRLTDAPFLAAATGATPSRRPVWFMRQAGRSLPEYRELRAGIGMLESCFDPELVCEITMQPIRRHGVDAAIL
FSDIVVPLKAAGIDLDIVAGVGPVVAAPVRSVADVRALPRLRPEEVGAVVEGVRLLVDALGQTPLIGFAGAPFTLASYLV
EGGPSKHHERTKAMMYADPKTWHELLGVLTDITIAFLRAQLDAGVDAVQLFDSWAGALSPADYRAFVLPHSERVFTEIAD
AGVPRIHFGVGTGELLGAMGEAGADVVGVDWRVSLTEAARRVGPGKALQGNLDPAVLFAGPRAVEAHARRIAEEADRALA
LGAAGHIFNLGHGVLPDTDPGVLTALVELVHEL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=40.625, Blast_Score=245, Evalue=5e-65,
Organism=Escherichia coli, GI2367337, Length=334, Percent_Identity=46.4071856287425, Blast_Score=263, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=34.8441926345609, Blast_Score=215, Evalue=9e-57,
Organism=Drosophila melanogaster, GI19921920, Length=354, Percent_Identity=38.135593220339, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI221330099, Length=354, Percent_Identity=38.135593220339, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_NOCFA (Q5YTA5)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119950.1
- HSSP:   P06132
- ProteinModelPortal:   Q5YTA5
- SMR:   Q5YTA5
- GeneID:   3109561
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa37380
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   NFAR247156:NFA37380-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37547; Mature: 37415

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 84-84 BINDING 159-159 BINDING 214-214 BINDING 333-333

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMSTHTRRRLTDAPFLAAATGATPSRRPVWFMRQAGRSLPEYRELRAGIGMLESCFDP
CCCCCCHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
ELVCEITMQPIRRHGVDAAILFSDIVVPLKAAGIDLDIVAGVGPVVAAPVRSVADVRALP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHC
RLRPEEVGAVVEGVRLLVDALGQTPLIGFAGAPFTLASYLVEGGPSKHHERTKAMMYADP
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHEEECH
KTWHELLGVLTDITIAFLRAQLDAGVDAVQLFDSWAGALSPADYRAFVLPHSERVFTEIA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
DAGVPRIHFGVGTGELLGAMGEAGADVVGVDWRVSLTEAARRVGPGKALQGNLDPAVLFA
HCCCCEEEEECCHHHHHHHHCCCCCCEEECCEEEEHHHHHHHCCCCCCCCCCCCCEEEEE
GPRAVEAHARRIAEEADRALALGAAGHIFNLGHGVLPDTDPGVLTALVELVHEL
CCHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure 
AGMSTHTRRRLTDAPFLAAATGATPSRRPVWFMRQAGRSLPEYRELRAGIGMLESCFDP
CCCCCHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
ELVCEITMQPIRRHGVDAAILFSDIVVPLKAAGIDLDIVAGVGPVVAAPVRSVADVRALP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHC
RLRPEEVGAVVEGVRLLVDALGQTPLIGFAGAPFTLASYLVEGGPSKHHERTKAMMYADP
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHEEECH
KTWHELLGVLTDITIAFLRAQLDAGVDAVQLFDSWAGALSPADYRAFVLPHSERVFTEIA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
DAGVPRIHFGVGTGELLGAMGEAGADVVGVDWRVSLTEAARRVGPGKALQGNLDPAVLFA
HCCCCEEEEECCHHHHHHHHCCCCCCEEECCEEEEHHHHHHHCCCCCCCCCCCCCEEEEE
GPRAVEAHARRIAEEADRALALGAAGHIFNLGHGVLPDTDPGVLTALVELVHEL
CCHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA