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The map label for this gene is dxs

Identifier: 54025711

GI number: 54025711

Start: 3960138

End: 3962033

Strand: Reverse

Name: dxs

Synonym: nfa37410

Alternate gene names: 54025711

Gene position: 3962033-3960138 (Counterclockwise)

Preceding gene: 54025713

Following gene: 54025708

Centisome position: 65.8

GC content: 71.78

Gene sequence:

>1896_bases
GTGGGAGTGCTTTCCCGGGTCGACACACCCGAAGACGTGCGCCGGCTGAACGTGGCCGAGTTGCGGGAGCTCGCGGAGGA
GATCCGCGAGTTCCTGGTGCGCAAGGTCGCGGCGACCGGCGGTCACCTCGGACCGAACCTCGGCGTCGTCGAGCTGACCA
TCGCGCTGCACCGGGTGTTCGACTCTCCGGCCGACCCGTTGATCTTCGACACCGGCCACCAGGCCTACGTCCACAAGATC
CTCACCGGCCGCAAGGACCGGTTCGACGACCTGCGCAAGCAGGGCGGGCTGTCCGGCTACCCCAGCCGCGCCGAGAGCCC
CCACGACTGGGTCGAGTCCTCGCACGCCTCCGCGGCGCTGTCCTACGCCGACGGCCTGGCCAAGGCGTTCGCCCTGGGCG
GGCAGGACCGGCACGTGGTCGCCGTCGTCGGCGACGGCGCGCTCACCGGCGGCATGTGCTGGGAGGCGCTGAACAACATC
GCCGCGGCCCCGGATCGCCCGGTGGTCGTGGTGGTCAACGACAACGGCCGCTCCTACGCTCCCACCATCGGTGGGCTGGC
CGATCGGCTGACCGCACTGCGCACCCAGCCCGCCTACGAGCACGCGCTCGACGCGGGCAAGCGGCTGCTCAAGAGCATTC
CGCGGGTGGGGGAGTCGGCGTATTCGATGGTGCACGCGGTCAAGGCGGGCATCAAGGACGCGGTGAGCCCGCAGGAACTC
TTCAGCGATCTCGGCCTGAAGTACGTGGGCCCGGTCGACGGGCACGACGTGGTGGCGATGGAGTCGGCGCTGCGCCGCGC
CAAGGACTTCGGCGGACCGGTGGTCGTGCACGCGGTCACCCAGAAGGGCCGCGGCTACGAGCACGCCGAGAACCACGTCG
CCGATCAGATGCACGCCTGTGACCCGATCGACCCGCTCACCGGGCGGCCGCTGGGCGGGGCCAAGGCGCGCGGCTGGACC
TCGGTGTTCTCCGAGGAACTGATCGAGCACGCGCGCCGGCGCTCCGACATCGTCGCCATCACCGCCGCGATGCCAGGCCC
GACCGGGTTGTCCGCCTTCGGCGAGCGTTTCCCGGACCGCATGTTCGACGTGGGCATCGCCGAACAGCACGCGATGGCCT
CCGCGGCGGGGCTGGCGCTGGGCGGTATGCACCCGGTGGTCGCGATCTACTCGACCTTCCTCAACCGCGCCTTCGACCAG
CTGCTCATGGATGTGGCGCTGTTGAAGCAGCCGGTGACGGTGGTGCTGGACCGCGCGGGCATCACCGGCCCGGACGGCGC
CAGCCACAACGGCATGTGGGATCTGTCGCTGCTCGGCATCATCCCCGGCATCCGGGTCGCCGCGCCGCGCGATGCCGCCA
CCCTGCGCGAGGAACTCGGGGAGGCGCTGGCCGTCACCGACGGGCCGACCGTGTTGCGGTTCCCGAAAGGCAGTGTCGCC
GAAGACCTCACCGCGGTGGAGCGGATCGACGGTGTGGACGTGCTGCGCGCGGCCGACCCCGAGTCGGCGGTGCGCACCCA
GCGCGGTGACGTGCTGATCGTCGCGGTCGGCCCGTTCGCCCGGATCGGGCTCGCGGCCGCCGAGCTGCTCGCTCCGGAAG
GGGTGTCGGTCACCGTCGTCGATCCCCGCTGGGTGCTGCCGGTCTCCGACACCGTGGTCAAGCTCGCGGAGAACTACCGG
CTCGTGGTCACCCTGGAGGACAGCGGCCTGCACGGCGGCATCGGGTCCACGGTGTCGGCGCGGCTGCGGTCGGTCGGCCT
GGACGTGCCGACCCGCGACCTCGGCGTCCCGCAGCAGTTCCTCGACCACGCTTCCCGCGACCAGGTGCTCGAGCAGCTCG
GGCTCACCCCCACCGACGTCGCCCGGCGCATCGCGGGCTGGCTCGACGCCCGCTGA

Upstream 100 bases:

>100_bases
GCGTTGTCCGCGGAGGTGGGCACCCTGGTCGACGGAGCGCCCCGCCGAAGCTCCGTAGACTGAGCGGATCAGATGCGCTA
TCCGGAGGGAGCGAGTTCAG

Downstream 100 bases:

>100_bases
CCGGCGTCAGGCCGAGGCGGGCGGGGTCAGCGCGAGTGTCAGCCGTGGCACGGTCAGTTCGCGCTGCCAGGGGCGGGCGC
CGCCGGATTTGAGGAAGCCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MGVLSRVDTPEDVRRLNVAELRELAEEIREFLVRKVAATGGHLGPNLGVVELTIALHRVFDSPADPLIFDTGHQAYVHKI
LTGRKDRFDDLRKQGGLSGYPSRAESPHDWVESSHASAALSYADGLAKAFALGGQDRHVVAVVGDGALTGGMCWEALNNI
AAAPDRPVVVVVNDNGRSYAPTIGGLADRLTALRTQPAYEHALDAGKRLLKSIPRVGESAYSMVHAVKAGIKDAVSPQEL
FSDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVVVHAVTQKGRGYEHAENHVADQMHACDPIDPLTGRPLGGAKARGWT
SVFSEELIEHARRRSDIVAITAAMPGPTGLSAFGERFPDRMFDVGIAEQHAMASAAGLALGGMHPVVAIYSTFLNRAFDQ
LLMDVALLKQPVTVVLDRAGITGPDGASHNGMWDLSLLGIIPGIRVAAPRDAATLREELGEALAVTDGPTVLRFPKGSVA
EDLTAVERIDGVDVLRAADPESAVRTQRGDVLIVAVGPFARIGLAAAELLAPEGVSVTVVDPRWVLPVSDTVVKLAENYR
LVVTLEDSGLHGGIGSTVSARLRSVGLDVPTRDLGVPQQFLDHASRDQVLEQLGLTPTDVARRIAGWLDAR

Sequences:

>Translated_631_residues
MGVLSRVDTPEDVRRLNVAELRELAEEIREFLVRKVAATGGHLGPNLGVVELTIALHRVFDSPADPLIFDTGHQAYVHKI
LTGRKDRFDDLRKQGGLSGYPSRAESPHDWVESSHASAALSYADGLAKAFALGGQDRHVVAVVGDGALTGGMCWEALNNI
AAAPDRPVVVVVNDNGRSYAPTIGGLADRLTALRTQPAYEHALDAGKRLLKSIPRVGESAYSMVHAVKAGIKDAVSPQEL
FSDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVVVHAVTQKGRGYEHAENHVADQMHACDPIDPLTGRPLGGAKARGWT
SVFSEELIEHARRRSDIVAITAAMPGPTGLSAFGERFPDRMFDVGIAEQHAMASAAGLALGGMHPVVAIYSTFLNRAFDQ
LLMDVALLKQPVTVVLDRAGITGPDGASHNGMWDLSLLGIIPGIRVAAPRDAATLREELGEALAVTDGPTVLRFPKGSVA
EDLTAVERIDGVDVLRAADPESAVRTQRGDVLIVAVGPFARIGLAAAELLAPEGVSVTVVDPRWVLPVSDTVVKLAENYR
LVVTLEDSGLHGGIGSTVSARLRSVGLDVPTRDLGVPQQFLDHASRDQVLEQLGLTPTDVARRIAGWLDAR
>Mature_630_residues
GVLSRVDTPEDVRRLNVAELRELAEEIREFLVRKVAATGGHLGPNLGVVELTIALHRVFDSPADPLIFDTGHQAYVHKIL
TGRKDRFDDLRKQGGLSGYPSRAESPHDWVESSHASAALSYADGLAKAFALGGQDRHVVAVVGDGALTGGMCWEALNNIA
AAPDRPVVVVVNDNGRSYAPTIGGLADRLTALRTQPAYEHALDAGKRLLKSIPRVGESAYSMVHAVKAGIKDAVSPQELF
SDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVVVHAVTQKGRGYEHAENHVADQMHACDPIDPLTGRPLGGAKARGWTS
VFSEELIEHARRRSDIVAITAAMPGPTGLSAFGERFPDRMFDVGIAEQHAMASAAGLALGGMHPVVAIYSTFLNRAFDQL
LMDVALLKQPVTVVLDRAGITGPDGASHNGMWDLSLLGIIPGIRVAAPRDAATLREELGEALAVTDGPTVLRFPKGSVAE
DLTAVERIDGVDVLRAADPESAVRTQRGDVLIVAVGPFARIGLAAAELLAPEGVSVTVVDPRWVLPVSDTVVKLAENYRL
VVTLEDSGLHGGIGSTVSARLRSVGLDVPTRDLGVPQQFLDHASRDQVLEQLGLTPTDVARRIAGWLDAR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=247, Percent_Identity=29.1497975708502, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507521, Length=247, Percent_Identity=29.1497975708502, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637459, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI225637461, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI225637463, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI133778974, Length=410, Percent_Identity=26.3414634146341, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786622, Length=631, Percent_Identity=38.1933438985737, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17539652, Length=439, Percent_Identity=26.879271070615, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666278, Length=601, Percent_Identity=24.7920133111481, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551847, Length=250, Percent_Identity=29.6, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550715, Length=250, Percent_Identity=29.6, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24645119, Length=250, Percent_Identity=29.6, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_NOCFA (Q5YTA2)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119953.1
- ProteinModelPortal:   Q5YTA2
- SMR:   Q5YTA2
- GeneID:   3109766
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa37410
- NMPDR:   fig|247156.1.peg.3643
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   NFAR247156:NFA37410-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67107; Mature: 66976

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLSRVDTPEDVRRLNVAELRELAEEIREFLVRKVAATGGHLGPNLGVVELTIALHRVF
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DSPADPLIFDTGHQAYVHKILTGRKDRFDDLRKQGGLSGYPSRAESPHDWVESSHASAAL
CCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
SYADGLAKAFALGGQDRHVVAVVGDGALTGGMCWEALNNIAAAPDRPVVVVVNDNGRSYA
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEC
PTIGGLADRLTALRTQPAYEHALDAGKRLLKSIPRVGESAYSMVHAVKAGIKDAVSPQEL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
FSDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVVVHAVTQKGRGYEHAENHVADQMHAC
HHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHHHHHCC
DPIDPLTGRPLGGAKARGWTSVFSEELIEHARRRSDIVAITAAMPGPTGLSAFGERFPDR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCHH
MFDVGIAEQHAMASAAGLALGGMHPVVAIYSTFLNRAFDQLLMDVALLKQPVTVVLDRAG
HHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCC
ITGPDGASHNGMWDLSLLGIIPGIRVAAPRDAATLREELGEALAVTDGPTVLRFPKGSVA
CCCCCCCCCCCEEEHHHHHHCCCCEEECCCHHHHHHHHHCCEEEECCCCCEEECCCCCHH
EDLTAVERIDGVDVLRAADPESAVRTQRGDVLIVAVGPFARIGLAAAELLAPEGVSVTVV
HHHHHHHHHCCCHHHHCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEE
DPRWVLPVSDTVVKLAENYRLVVTLEDSGLHGGIGSTVSARLRSVGLDVPTRDLGVPQQF
CCEEEECCHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHH
LDHASRDQVLEQLGLTPTDVARRIAGWLDAR
HHCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVLSRVDTPEDVRRLNVAELRELAEEIREFLVRKVAATGGHLGPNLGVVELTIALHRVF
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DSPADPLIFDTGHQAYVHKILTGRKDRFDDLRKQGGLSGYPSRAESPHDWVESSHASAAL
CCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
SYADGLAKAFALGGQDRHVVAVVGDGALTGGMCWEALNNIAAAPDRPVVVVVNDNGRSYA
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEC
PTIGGLADRLTALRTQPAYEHALDAGKRLLKSIPRVGESAYSMVHAVKAGIKDAVSPQEL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
FSDLGLKYVGPVDGHDVVAMESALRRAKDFGGPVVVHAVTQKGRGYEHAENHVADQMHAC
HHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHHHHHCC
DPIDPLTGRPLGGAKARGWTSVFSEELIEHARRRSDIVAITAAMPGPTGLSAFGERFPDR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCHH
MFDVGIAEQHAMASAAGLALGGMHPVVAIYSTFLNRAFDQLLMDVALLKQPVTVVLDRAG
HHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCC
ITGPDGASHNGMWDLSLLGIIPGIRVAAPRDAATLREELGEALAVTDGPTVLRFPKGSVA
CCCCCCCCCCCEEEHHHHHHCCCCEEECCCHHHHHHHHHCCEEEECCCCCEEECCCCCHH
EDLTAVERIDGVDVLRAADPESAVRTQRGDVLIVAVGPFARIGLAAAELLAPEGVSVTVV
HHHHHHHHHCCCHHHHCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEE
DPRWVLPVSDTVVKLAENYRLVVTLEDSGLHGGIGSTVSARLRSVGLDVPTRDLGVPQQF
CCEEEECCHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHH
LDHASRDQVLEQLGLTPTDVARRIAGWLDAR
HHCCHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA