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The map label for this gene is hemY [H]

Identifier: 54025707

GI number: 54025707

Start: 3955521

End: 3956867

Strand: Reverse

Name: hemY [H]

Synonym: nfa37370

Alternate gene names: 54025707

Gene position: 3956867-3955521 (Counterclockwise)

Preceding gene: 54025708

Following gene: 54025706

Centisome position: 65.72

GC content: 76.54

Gene sequence:

>1347_bases
ATGAGGATCGCGATTGTCGGCGGCGGGATCAGCGGGCTCGTCGCGGCGTACCGGCTGCGCACCCTGCTCGGCCCCGCGGC
CGATCTCGTCCTGGTCGATCGCGCCGAGCGAGTGGGCGGCATCCTGTACACCGCCGACATCCAGGGCGAGCCCGTCGACC
TGGGCGCGGAGGCGTTCGTCGGCCGCCGCCCCGAGGTGCCCGCGCTGCTGCGCGAGCTGGGGCTCGAGGACCAGCTGGTG
TATCCGGCGGGCAAGCGACCGCTGCTGTGGGCGGGCGGTGCCACGCACCCGCTGCCGCCCCGCACCCTGATGGGCATCCC
GTCCGACGCGGAGTCGATGCGCGGGCTCGTCGACGACGACACCCTGGACCGGATCGCGAGCGAGTCGGCTCGGCCGCTGG
CCTGGTACCCGGACAGCGACCTCGACGTGCACAGCCTCGTCGCCGACCGGTTCGGCGCCCAGGTGGTCGAACGCAGCGTC
GACCCGCTGCTCGGCGGGGTGTACGCGGGCAGCGCCCGCTCGATCGGTGTGCGTGCCGCGCTGCCCACGCTGGCGGCCGC
GCTGGACGCCGGCGCGCCCAGCCTCACCCACGCGGTGGCCGCCGCACTCCCGCCGCCCTCGGACGCCCCGGTCTTCGGCG
GCATCCGCGACGGGTACCGGGTCCTGCTGGACGCCCTGGTGGCGGCGTCGGGGCTGCGCTTCGTCGCGGCCACGGCGGCC
ACCCGCCTCGCGCGCGCGAGCGGCGGCTGGGTGCTCGACCCGCTCGGCCTGGTGGACGCGGTCGTGGTCGCCGCGCCCGC
ACCGGTGGCGGCGCGGCTGCTGCGCTACGTCGCGCCCGGCGCGGCCGACGCCGCCGCGGGGATCGAACTGTCCTCCTCGG
CGGTGGTGGCACTGTCGCTGCCGCCCGACACCGCGTTGCCGGACAACTCGGGCATCCTCGTCGCCACCGGGGAGCCCTTG
CGCGCCAAGGCGTTCACACTGTCCAGCCGCAAGTGGCCGCACCTGGCCGAGCGCAAGACCGCGCTGGTGCGGGCCTCGTT
CGGCAAGTTCGGTGACGACGCCCCGCTGCGCTGGAGCGACGCGGAACTGATCGCCGCGGCCACCGAGGACCTGGCCACCG
TCACCGGTGTCCCGATCACCCCGGTCGAGGCGGTGGTGCAGCGCTGGCCGGGCGGGCTGGCCCAGTACGCGCCGGGCCAC
ACCGACCGCGTCGCCGAAATCGACCGGGCGGTGGCCGAGTTGGACGGCCTGGCCGTCGCGGGCGCCTACCTGCGCGGCGT
CGGCGTCCCGGCCTGCGTGGCCGCCGGCGACGCCGCCGCCCGCCGCATCGCCGGCTTCCTCTCCTGA

Upstream 100 bases:

>100_bases
TTGACCCGCCGCGGGAAAATCGCGCTAGCACGGTGACTTCGGCGACAGCGGTGGTACCGGATGTCCGCGCGATGAGCACG
GCGGGCTACCGTCGAAAGCC

Downstream 100 bases:

>100_bases
GTGGGAGGGCACACGCGTTACCTCCGGTCCCGCAGTGGCACGATGGACCCATGGCGCGACTCGATTATCAAGCTCTCAAC
TCCACCATCCGATACCTGAT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRIAIVGGGISGLVAAYRLRTLLGPAADLVLVDRAERVGGILYTADIQGEPVDLGAEAFVGRRPEVPALLRELGLEDQLV
YPAGKRPLLWAGGATHPLPPRTLMGIPSDAESMRGLVDDDTLDRIASESARPLAWYPDSDLDVHSLVADRFGAQVVERSV
DPLLGGVYAGSARSIGVRAALPTLAAALDAGAPSLTHAVAAALPPPSDAPVFGGIRDGYRVLLDALVAASGLRFVAATAA
TRLARASGGWVLDPLGLVDAVVVAAPAPVAARLLRYVAPGAADAAAGIELSSSAVVALSLPPDTALPDNSGILVATGEPL
RAKAFTLSSRKWPHLAERKTALVRASFGKFGDDAPLRWSDAELIAAATEDLATVTGVPITPVEAVVQRWPGGLAQYAPGH
TDRVAEIDRAVAELDGLAVAGAYLRGVGVPACVAAGDAAARRIAGFLS

Sequences:

>Translated_448_residues
MRIAIVGGGISGLVAAYRLRTLLGPAADLVLVDRAERVGGILYTADIQGEPVDLGAEAFVGRRPEVPALLRELGLEDQLV
YPAGKRPLLWAGGATHPLPPRTLMGIPSDAESMRGLVDDDTLDRIASESARPLAWYPDSDLDVHSLVADRFGAQVVERSV
DPLLGGVYAGSARSIGVRAALPTLAAALDAGAPSLTHAVAAALPPPSDAPVFGGIRDGYRVLLDALVAASGLRFVAATAA
TRLARASGGWVLDPLGLVDAVVVAAPAPVAARLLRYVAPGAADAAAGIELSSSAVVALSLPPDTALPDNSGILVATGEPL
RAKAFTLSSRKWPHLAERKTALVRASFGKFGDDAPLRWSDAELIAAATEDLATVTGVPITPVEAVVQRWPGGLAQYAPGH
TDRVAEIDRAVAELDGLAVAGAYLRGVGVPACVAAGDAAARRIAGFLS
>Mature_448_residues
MRIAIVGGGISGLVAAYRLRTLLGPAADLVLVDRAERVGGILYTADIQGEPVDLGAEAFVGRRPEVPALLRELGLEDQLV
YPAGKRPLLWAGGATHPLPPRTLMGIPSDAESMRGLVDDDTLDRIASESARPLAWYPDSDLDVHSLVADRFGAQVVERSV
DPLLGGVYAGSARSIGVRAALPTLAAALDAGAPSLTHAVAAALPPPSDAPVFGGIRDGYRVLLDALVAASGLRFVAATAA
TRLARASGGWVLDPLGLVDAVVVAAPAPVAARLLRYVAPGAADAAAGIELSSSAVVALSLPPDTALPDNSGILVATGEPL
RAKAFTLSSRKWPHLAERKTALVRASFGKFGDDAPLRWSDAELIAAATEDLATVTGVPITPVEAVVQRWPGGLAQYAPGH
TDRVAEIDRAVAELDGLAVAGAYLRGVGVPACVAAGDAAARRIAGFLS

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=489, Percent_Identity=26.1758691206544, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4506001, Length=489, Percent_Identity=26.1758691206544, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 45921; Mature: 45921

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAIVGGGISGLVAAYRLRTLLGPAADLVLVDRAERVGGILYTADIQGEPVDLGAEAFV
CEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCEEEEECCCCCCCCCCHHHHC
GRRPEVPALLRELGLEDQLVYPAGKRPLLWAGGATHPLPPRTLMGIPSDAESMRGLVDDD
CCCCCHHHHHHHCCCCCEEECCCCCCCEEEECCCCCCCCCHHEECCCCCHHHHCCCCCHH
TLDRIASESARPLAWYPDSDLDVHSLVADRFGAQVVERSVDPLLGGVYAGSARSIGVRAA
HHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LPTLAAALDAGAPSLTHAVAAALPPPSDAPVFGGIRDGYRVLLDALVAASGLRFVAATAA
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
TRLARASGGWVLDPLGLVDAVVVAAPAPVAARLLRYVAPGAADAAAGIELSSSAVVALSL
HHHHHCCCCEEECHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCEECCCEEEEEEC
PPDTALPDNSGILVATGEPLRAKAFTLSSRKWPHLAERKTALVRASFGKFGDDAPLRWSD
CCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
AELIAAATEDLATVTGVPITPVEAVVQRWPGGLAQYAPGHTDRVAEIDRAVAELDGLAVA
CHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHCCHHHH
GAYLRGVGVPACVAAGDAAARRIAGFLS
HHHHHCCCCCHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MRIAIVGGGISGLVAAYRLRTLLGPAADLVLVDRAERVGGILYTADIQGEPVDLGAEAFV
CEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCEEEEECCCCCCCCCCHHHHC
GRRPEVPALLRELGLEDQLVYPAGKRPLLWAGGATHPLPPRTLMGIPSDAESMRGLVDDD
CCCCCHHHHHHHCCCCCEEECCCCCCCEEEECCCCCCCCCHHEECCCCCHHHHCCCCCHH
TLDRIASESARPLAWYPDSDLDVHSLVADRFGAQVVERSVDPLLGGVYAGSARSIGVRAA
HHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LPTLAAALDAGAPSLTHAVAAALPPPSDAPVFGGIRDGYRVLLDALVAASGLRFVAATAA
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
TRLARASGGWVLDPLGLVDAVVVAAPAPVAARLLRYVAPGAADAAAGIELSSSAVVALSL
HHHHHCCCCEEECHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCEECCCEEEEEEC
PPDTALPDNSGILVATGEPLRAKAFTLSSRKWPHLAERKTALVRASFGKFGDDAPLRWSD
CCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
AELIAAATEDLATVTGVPITPVEAVVQRWPGGLAQYAPGHTDRVAEIDRAVAELDGLAVA
CHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHCCHHHH
GAYLRGVGVPACVAAGDAAARRIAGFLS
HHHHHCCCCCHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]