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The map label for this gene is apt

Identifier: 54025658

GI number: 54025658

Start: 3905980

End: 3906555

Strand: Reverse

Name: apt

Synonym: nfa36880

Alternate gene names: 54025658

Gene position: 3906555-3905980 (Counterclockwise)

Preceding gene: 54025659

Following gene: 54025657

Centisome position: 64.88

GC content: 74.31

Gene sequence:

>576_bases
ATGAGCAAGCACGCGGCGGTGGAGTCCGACGAGCACGTGGCCGAGCGGACCGCCGAGGCGGCGCGGCAGGTCGAACGCCT
CACCCGCTGGCACGACGATTTCCCGACCCCCGGTGTCCGCTTCGCCGACCTCACCCCCGTCTTCGCCGACGCCGAGGGCT
TCCGCTCGGTGATCGAATCGCTGGCCGCCTGCGCCCCCGACGCCGATCTGGTCGCCGGCGTGGATGCGCGGGGGTTCCTG
CTCGGCGCCGGGGTGGCGGCCACGCTGGGCACCGGTGTGCTCGCCGTCCGGAAGGGCGGCAAACTGCCGCCGCCGGTGAT
CAGCCGCGAGTACAGCCTGGAGTACGGCTCGGCGGCGCTGGAGATCCCCGGCAACGGGGTGGAACTGCGCGGACGCCGAG
TGTTGCTGCTCGACGACGTGCTGGCCACCGGCGGCACGCTGGCCGCCGCCGCGCACCTGTTCGTCGAGGCTGGCGCCCAG
GTCGTGGCCGCCGCGGTGGTGCTGGAGCTGGAGTTCCTCGGCGGCCGCGCCCGCCAGGGCGACTACCCGCTGACCTCGAT
CCTCCGCCTGCCCTGA

Upstream 100 bases:

>100_bases
CCACACAGGGTGGCACCGGCTGGAACATGGATCGCTGGGTGTTGCGGCGCTGACATGTGTGGCGGGTCGGGAGCGGGTGA
GTGATCATGGAGAGGTGTCG

Downstream 100 bases:

>100_bases
CGACCGTGCGCGAATAATCGCTGGCGACTCCACCGGTCGCTGGTTACTCTGGATCCCGTCCTCGTCCCCGACGATCGGAG
CCCATGGTGCTTTCCTGAGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MSKHAAVESDEHVAERTAEAARQVERLTRWHDDFPTPGVRFADLTPVFADAEGFRSVIESLAACAPDADLVAGVDARGFL
LGAGVAATLGTGVLAVRKGGKLPPPVISREYSLEYGSAALEIPGNGVELRGRRVLLLDDVLATGGTLAAAAHLFVEAGAQ
VVAAAVVLELEFLGGRARQGDYPLTSILRLP

Sequences:

>Translated_191_residues
MSKHAAVESDEHVAERTAEAARQVERLTRWHDDFPTPGVRFADLTPVFADAEGFRSVIESLAACAPDADLVAGVDARGFL
LGAGVAATLGTGVLAVRKGGKLPPPVISREYSLEYGSAALEIPGNGVELRGRRVLLLDDVLATGGTLAAAAHLFVEAGAQ
VVAAAVVLELEFLGGRARQGDYPLTSILRLP
>Mature_190_residues
SKHAAVESDEHVAERTAEAARQVERLTRWHDDFPTPGVRFADLTPVFADAEGFRSVIESLAACAPDADLVAGVDARGFLL
GAGVAATLGTGVLAVRKGGKLPPPVISREYSLEYGSAALEIPGNGVELRGRRVLLLDDVLATGGTLAAAAHLFVEAGAQV
VAAAVVLELEFLGGRARQGDYPLTSILRLP

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=43.859649122807, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI71773201, Length=126, Percent_Identity=47.6190476190476, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1786675, Length=177, Percent_Identity=38.9830508474576, Blast_Score=110, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17509087, Length=174, Percent_Identity=39.0804597701149, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323619, Length=168, Percent_Identity=34.5238095238095, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320649, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136334, Length=152, Percent_Identity=38.1578947368421, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_NOCFA (Q5YTF5)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119900.1
- ProteinModelPortal:   Q5YTF5
- SMR:   Q5YTF5
- GeneID:   3109855
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa36880
- NMPDR:   fig|247156.1.peg.3595
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   NFAR247156:NFA36880-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19951; Mature: 19820

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHAAVESDEHVAERTAEAARQVERLTRWHDDFPTPGVRFADLTPVFADAEGFRSVIES
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHCCHHHHHHHHHH
LAACAPDADLVAGVDARGFLLGAGVAATLGTGVLAVRKGGKLPPPVISREYSLEYGSAAL
HHHCCCCCHHEECCCCCCEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCEEE
EIPGNGVELRGRRVLLLDDVLATGGTLAAAAHLFVEAGAQVVAAAVVLELEFLGGRARQG
EECCCCEEECCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DYPLTSILRLP
CCCHHHHCCCC
>Mature Secondary Structure 
SKHAAVESDEHVAERTAEAARQVERLTRWHDDFPTPGVRFADLTPVFADAEGFRSVIES
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHCCHHHHHHHHHH
LAACAPDADLVAGVDARGFLLGAGVAATLGTGVLAVRKGGKLPPPVISREYSLEYGSAAL
HHHCCCCCHHEECCCCCCEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCEEE
EIPGNGVELRGRRVLLLDDVLATGGTLAAAAHLFVEAGAQVVAAAVVLELEFLGGRARQG
EECCCCEEECCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DYPLTSILRLP
CCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA