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The map label for this gene is ribBA

Identifier: 54025570

GI number: 54025570

Start: 3811546

End: 3812790

Strand: Reverse

Name: ribBA

Synonym: nfa36000

Alternate gene names: 54025570

Gene position: 3812790-3811546 (Counterclockwise)

Preceding gene: 54025571

Following gene: 54025569

Centisome position: 63.32

GC content: 69.96

Gene sequence:

>1245_bases
GTGACCAGGTTCGACACCATCGAGCGCGCAGTCGCCGACATCGCCGCCGGTAAGGCGGTCGTCGTCGTCGACGACGAGGA
CCGCGAGAACGAGGGCGACCTCATCTTCGCGGCGGAGAAGGCCACCCCCGAACTGGTCGCCTTCATGATCCGCTACACCT
CCGGCTACATCTGTGTGCCGCTCACCGGTGAGGACTGCGATCGGCTCGGCCTGCCGCCGATGTATGCGACCAACCAGGAC
AAGCACGGCACCGCCTACACGGTCTCGGTCGACGCGCGCGAGGGCATCACCACCGGAATCTCGGCGGCCGACCGGGCCAC
CACCATGCGGCTGCTCGCCGACGCCGACGCGAAGGCCGACGACCTGACCCGCCCCGGCCACGTCGTGCCGTTGCGCGCCA
AGGACGGCGGCGTGCTGCGCCGCCCCGGCCACACCGAGGCGGCCGTGGACCTGGCGCGGATGGCCGGGTTGCGGCCGGCC
GGCGTGATCTGCGAGATCGTCAGCCAGAAGGACGAGGGCCACATGGCCCGCACCGAGGAACTGCGCGTGTTCGCCGACGA
CCACGATCTGGCGCTGATCTCGATCGCGGACATGATCGCCTGGCGGCGCAAGCACGAGAAGCAGGTGGTGCGGGTCGCCG
AGGCGCGCATCCCCACCGCGCACGGCGCGTTCACCGCGGTCGGCTACCAGAGCATCTACGACGATGTCGAACACGTCGCC
CTGGTGCGCGGCGACATCGGCGACGGCGAGGACGTGCTGGTGCGCGTGCACTCCGAATGCCTCACCGGTGACGTGTTCGG
TTCGCTGCGCTGCGACTGCGGGCCGCAACTGGACGCGGCCCTGGAGATGGTGGACCAGGAAGGCCGGGGCGTCGTGCTGT
ACATGCGCGGGCACGAGGGCCGCGGCATCGGCCTGATGCACAAGCTGCAGGCCTACCAGTTGCAGGACTCCGGCCGCGAC
ACCGTCGACGCCAACCTGGATCTCGGTCTGCCCGCCGATGCCCGCGACTACGGCACCGGCGCCCAGATCCTGGTGGACCT
GGGCATCCGGTCGATGCGCCTGCTGACCAACAACCCCGCCAAGCGGGTCGGCCTGGACGGCTACGGCCTCACCATCACCG
AACGGGTGCCGATGCCCCTGCGCGCCAACGCCGAGAATCTGCGCTACCTGCGCACCAAGCGCGACCGCATGGGGCACGAC
CTGGTCGGGCTCGACGATCTGGATCTGGGAGAGACCGCACAGTGA

Upstream 100 bases:

>100_bases
CCGTGCGTCCACCGGGCGACTCGCAGGGGGCGCGAGCCGTGCCGGCCGGGCCAACGGCAATACTGTTCAAGCACCTATTC
CTAGAGGGAGCGCAGCAGAC

Downstream 100 bases:

>100_bases
GCGGTATTCGCGGGAAAGGCATTTCGGAATGAGCGGCACCGGTGTTCCCACCTTCGAGCTGGCCGACGCCAAGGACCTGC
GCCTGGGCATCGTCGCGTCG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTRFDTIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMIRYTSGYICVPLTGEDCDRLGLPPMYATNQD
KHGTAYTVSVDAREGITTGISAADRATTMRLLADADAKADDLTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLRPA
GVICEIVSQKDEGHMARTEELRVFADDHDLALISIADMIAWRRKHEKQVVRVAEARIPTAHGAFTAVGYQSIYDDVEHVA
LVRGDIGDGEDVLVRVHSECLTGDVFGSLRCDCGPQLDAALEMVDQEGRGVVLYMRGHEGRGIGLMHKLQAYQLQDSGRD
TVDANLDLGLPADARDYGTGAQILVDLGIRSMRLLTNNPAKRVGLDGYGLTITERVPMPLRANAENLRYLRTKRDRMGHD
LVGLDDLDLGETAQ

Sequences:

>Translated_414_residues
MTRFDTIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMIRYTSGYICVPLTGEDCDRLGLPPMYATNQD
KHGTAYTVSVDAREGITTGISAADRATTMRLLADADAKADDLTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLRPA
GVICEIVSQKDEGHMARTEELRVFADDHDLALISIADMIAWRRKHEKQVVRVAEARIPTAHGAFTAVGYQSIYDDVEHVA
LVRGDIGDGEDVLVRVHSECLTGDVFGSLRCDCGPQLDAALEMVDQEGRGVVLYMRGHEGRGIGLMHKLQAYQLQDSGRD
TVDANLDLGLPADARDYGTGAQILVDLGIRSMRLLTNNPAKRVGLDGYGLTITERVPMPLRANAENLRYLRTKRDRMGHD
LVGLDDLDLGETAQ
>Mature_413_residues
TRFDTIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMIRYTSGYICVPLTGEDCDRLGLPPMYATNQDK
HGTAYTVSVDAREGITTGISAADRATTMRLLADADAKADDLTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLRPAG
VICEIVSQKDEGHMARTEELRVFADDHDLALISIADMIAWRRKHEKQVVRVAEARIPTAHGAFTAVGYQSIYDDVEHVAL
VRGDIGDGEDVLVRVHSECLTGDVFGSLRCDCGPQLDAALEMVDQEGRGVVLYMRGHEGRGIGLMHKLQAYQLQDSGRDT
VDANLDLGLPADARDYGTGAQILVDLGIRSMRLLTNNPAKRVGLDGYGLTITERVPMPLRANAENLRYLRTKRDRMGHDL
VGLDDLDLGETAQ

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1789420, Length=207, Percent_Identity=50.2415458937198, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=53.0927835051546, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=45.4106280193237, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=50, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBBA_NOCFA (Q5YTP3)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119812.1
- HSSP:   P0A7I7
- ProteinModelPortal:   Q5YTP3
- GeneID:   3111454
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa36000
- NMPDR:   fig|247156.1.peg.3513
- HOGENOM:   HBG735778
- OMA:   RCDCRMQ
- ProtClustDB:   PRK09311
- BioCyc:   NFAR247156:NFA36000-MONOMER
- BRENDA:   3.5.4.25
- BRENDA:   4.1.99.12
- HAMAP:   MF_01283
- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299
- Gene3D:   G3DSA:3.90.870.10
- PIRSF:   PIRSF001259
- TIGRFAMs:   TIGR00505
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12; =3.5.4.25

Molecular weight: Translated: 45053; Mature: 44921

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: ACT_SITE 333-333 ACT_SITE 335-335 BINDING 33-33 BINDING 165-165 BINDING 276-276 BINDING 321-321 BINDING 356-356 BINDING 361-361

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFDTIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMIRYTSGYICVP
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LTGEDCDRLGLPPMYATNQDKHGTAYTVSVDAREGITTGISAADRATTMRLLADADAKAD
ECCCCCHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHEEECCCCCCC
DLTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLRPAGVICEIVSQKDEGHMARTEE
CCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEECCE
LRVFADDHDLALISIADMIAWRRKHEKQVVRVAEARIPTAHGAFTAVGYQSIYDDVEHVA
EEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHEE
LVRGDIGDGEDVLVRVHSECLTGDVFGSLRCDCGPQLDAALEMVDQEGRGVVLYMRGHEG
EEECCCCCCCCEEEEEHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCEEEEEEECCCC
RGIGLMHKLQAYQLQDSGRDTVDANLDLGLPADARDYGTGAQILVDLGIRSMRLLTNNPA
CCCHHHHHHHHHEECCCCCCEEECCEECCCCCCCCCCCCCCEEEEECCCCEEEEECCCCH
KRVGLDGYGLTITERVPMPLRANAENLRYLRTKRDRMGHDLVGLDDLDLGETAQ
HHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRFDTIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMIRYTSGYICVP
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LTGEDCDRLGLPPMYATNQDKHGTAYTVSVDAREGITTGISAADRATTMRLLADADAKAD
ECCCCCHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHEEECCCCCCC
DLTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLRPAGVICEIVSQKDEGHMARTEE
CCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEECCE
LRVFADDHDLALISIADMIAWRRKHEKQVVRVAEARIPTAHGAFTAVGYQSIYDDVEHVA
EEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHEE
LVRGDIGDGEDVLVRVHSECLTGDVFGSLRCDCGPQLDAALEMVDQEGRGVVLYMRGHEG
EEECCCCCCCCEEEEEHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCEEEEEEECCCC
RGIGLMHKLQAYQLQDSGRDTVDANLDLGLPADARDYGTGAQILVDLGIRSMRLLTNNPA
CCCHHHHHHHHHEECCCCCCEEECCEECCCCCCCCCCCCCCEEEEECCCCEEEEECCCCH
KRVGLDGYGLTITERVPMPLRANAENLRYLRTKRDRMGHDLVGLDDLDLGETAQ
HHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA