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The map label for this gene is uvrC

Identifier: 54025564

GI number: 54025564

Start: 3804262

End: 3806283

Strand: Reverse

Name: uvrC

Synonym: nfa35940

Alternate gene names: 54025564

Gene position: 3806283-3804262 (Counterclockwise)

Preceding gene: 54025565

Following gene: 54025563

Centisome position: 63.21

GC content: 70.47

Gene sequence:

>2022_bases
GTGGCAGATCCAGCGACGTACCGGCCCGCGCCGGGCACCATCCCCGTCGAGCCGGGTGTGTACAAGTTCCGGGATTCCTA
CGGCCGGGTCATCTACGTCGGAAAGGCCAAGAGCCTGCGCAGCAGGCTGAACTCCTACTTCGCCGACGTCGCCTCGCTGC
ACCCGCGCACCAAGCAGATGGTCACCACCGCGGCGAGCGTGGAGTGGACCGTCGTCTCCACCGAGGTGGAGGCGCTGCAG
CTGGAATACAACTGGATCAAGGAATTCGATCCGCGGTTCAACGTGCGCTACCGCGACGACAAGTCCTATCCCGTGCTCGC
GGTCACGTTGAACGAGGAGTATCCGCGGCTGTTCGTGTACCGGGGAGCGCGCAAGAAGGGCGTGCGCTACTTCGGTCCCT
ACGCGCACGCCTGGGCCATCCGCGAGACGCTGGACCTGCTGCTGCGGGTGTTCCCCGCGCGGACCTGCTCCACCGGAGTC
TTCAAGCGGCACAACCAGATCGGCCGCCCCTGCCTGCTCGGCTACATCGACAAGTGCTCGGCGCCGTGCGTCGGGCGGGT
CAGCGCCGAGGAGCACCGGGCCATCGTGGAGGACTTCTGCGACTTCCTGGCCGGGCGCACCGACAAGATGGTGCGTGAGC
TGGAACGGCGTATGCATGCCGCCGCCGAGGACCTCGACTTCGAGACCGCGGCCCGGTTGCGCGACGACGTGCAGGCACTG
CGCCGGGCGCTGGAGAAGCAGGCGGTGGTGCTCGGCACCGGCACCGACGCCGACGTGATCGCCTTCGCCACCGACGAACT
GGAGGTGGCGGTGCAGATCTTCCACGTGCGCGACGGCCGCGTCCGCGGGCAGCGCGGCTGGGTGGTGGACAAGTCCGGCG
ACGCGGTGGACTCCGGCACCGGCGACGACGAGACCGGCGCGCTGGTCGAACAGTTCCTCACCCAGTTCTACGGCGAGCAG
GTCGCCTACGCCGACCAGACCCCCGACGAGCAGCCCGCCACGGTGGTGCCGCGCGAGGTGCTGGTGCCACAGCTGCCCGC
GGGACACGAGCAGCTCCAGGAGTGGCTGAGCCGGTTGCGCGGCTCGGCGGTGCGCCTGCGGGTGCCCCAGCGCGGCGACA
AGAAGGCGCTGGCCGAGACCGTCGAGCGCAACGCGAAGGAGGCGCTGGCCCAGCACAAGCTCAAGCGCGCCGGCGACCTC
ACCTCCCGCTCGGCGGCGCTGCAGGACATCCAGGACGCGCTCGACCTGGACAGCGCGCCGCTGCGCATCGAGTGCGTGGA
CATCAGCCACGTGCAGGGCACCGATGTGGTCGCCTCGCTGGTGGTGTTCGAGGACGGGTTGCCACGCAAGTCCGACTACC
GGCACTACGCCATCAAGGAGGCGGCGGGGGAGGGCCGCTCCGACGACGTGGGCAGCATCGCCGAGGTCACCCGTCGCCGG
TTCTACCGGCTGCGCAAGGAGCGCGACGAGGCCGAGCGCGACGAACTCGACGGCACCGCCGCGGGCGCGCCGCTGGTCGA
CGACGACGAGACGCCGACGTCCCGGCCCGGCATCGACCCGACCACCGGCCGCCCACGCAAGTTCGCCTACCCACCGAATC
TGTACGTCGTCGACGGCGGTGCGCCGCAGGTGGCGGCCGCCGCCGAGGTGCTCGACGAACTCGGCATCACCGACGTCGCC
GTGATCGGCCTGGCCAAGCGGCTCGAGGAGGTGTGGGTGCCCGGTGAACCGGACCCGGTGATCCTGCCCCGCAACAGCGA
GGCGCTGTTCCTGTTGCAGCGGGTGCGTGACGAAGCCCACCGCTTCGCCATCACCTTCCATCGCAGCAAGCGCTCGCGCC
GGATGACGGCCTCGGCGCTGGACTCGGTGCGCGGTCTGGGCGCGGCCCGGCGCACCGCGCTGGTGACCCACTTCGGCTCG
GTGGCCAAGCTCAAGGAGGCCACGGTCGAGGAGATCACCGAGGTGCCCGGGATCGGGGTGGCCACGGCGAAGGCGGTGCT
GGCGGCCCTACACCAGGAATGA

Upstream 100 bases:

>100_bases
GTCCCGACGCCCTGGTCGACGCGTTGCGCGCGCACGGGCTGGCCGTCCCGCGCTGACCAGCGCGCGCCGGGCTGTCGGAG
GCGGTCGATAGGCTGGTCAC

Downstream 100 bases:

>100_bases
CCGGCACCGGGAGTGCGCGGCGCACCGGGAACGAGCCGCTCCGACGGCACGTGACGCGCCCGCGGATCGGCCGTCGCGTA
GCTTGAGTGTCGGCGCCCGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MADPATYRPAPGTIPVEPGVYKFRDSYGRVIYVGKAKSLRSRLNSYFADVASLHPRTKQMVTTAASVEWTVVSTEVEALQ
LEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEYPRLFVYRGARKKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSTGV
FKRHNQIGRPCLLGYIDKCSAPCVGRVSAEEHRAIVEDFCDFLAGRTDKMVRELERRMHAAAEDLDFETAARLRDDVQAL
RRALEKQAVVLGTGTDADVIAFATDELEVAVQIFHVRDGRVRGQRGWVVDKSGDAVDSGTGDDETGALVEQFLTQFYGEQ
VAYADQTPDEQPATVVPREVLVPQLPAGHEQLQEWLSRLRGSAVRLRVPQRGDKKALAETVERNAKEALAQHKLKRAGDL
TSRSAALQDIQDALDLDSAPLRIECVDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIKEAAGEGRSDDVGSIAEVTRRR
FYRLRKERDEAERDELDGTAAGAPLVDDDETPTSRPGIDPTTGRPRKFAYPPNLYVVDGGAPQVAAAAEVLDELGITDVA
VIGLAKRLEEVWVPGEPDPVILPRNSEALFLLQRVRDEAHRFAITFHRSKRSRRMTASALDSVRGLGAARRTALVTHFGS
VAKLKEATVEEITEVPGIGVATAKAVLAALHQE

Sequences:

>Translated_673_residues
MADPATYRPAPGTIPVEPGVYKFRDSYGRVIYVGKAKSLRSRLNSYFADVASLHPRTKQMVTTAASVEWTVVSTEVEALQ
LEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEYPRLFVYRGARKKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSTGV
FKRHNQIGRPCLLGYIDKCSAPCVGRVSAEEHRAIVEDFCDFLAGRTDKMVRELERRMHAAAEDLDFETAARLRDDVQAL
RRALEKQAVVLGTGTDADVIAFATDELEVAVQIFHVRDGRVRGQRGWVVDKSGDAVDSGTGDDETGALVEQFLTQFYGEQ
VAYADQTPDEQPATVVPREVLVPQLPAGHEQLQEWLSRLRGSAVRLRVPQRGDKKALAETVERNAKEALAQHKLKRAGDL
TSRSAALQDIQDALDLDSAPLRIECVDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIKEAAGEGRSDDVGSIAEVTRRR
FYRLRKERDEAERDELDGTAAGAPLVDDDETPTSRPGIDPTTGRPRKFAYPPNLYVVDGGAPQVAAAAEVLDELGITDVA
VIGLAKRLEEVWVPGEPDPVILPRNSEALFLLQRVRDEAHRFAITFHRSKRSRRMTASALDSVRGLGAARRTALVTHFGS
VAKLKEATVEEITEVPGIGVATAKAVLAALHQE
>Mature_672_residues
ADPATYRPAPGTIPVEPGVYKFRDSYGRVIYVGKAKSLRSRLNSYFADVASLHPRTKQMVTTAASVEWTVVSTEVEALQL
EYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEYPRLFVYRGARKKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSTGVF
KRHNQIGRPCLLGYIDKCSAPCVGRVSAEEHRAIVEDFCDFLAGRTDKMVRELERRMHAAAEDLDFETAARLRDDVQALR
RALEKQAVVLGTGTDADVIAFATDELEVAVQIFHVRDGRVRGQRGWVVDKSGDAVDSGTGDDETGALVEQFLTQFYGEQV
AYADQTPDEQPATVVPREVLVPQLPAGHEQLQEWLSRLRGSAVRLRVPQRGDKKALAETVERNAKEALAQHKLKRAGDLT
SRSAALQDIQDALDLDSAPLRIECVDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIKEAAGEGRSDDVGSIAEVTRRRF
YRLRKERDEAERDELDGTAAGAPLVDDDETPTSRPGIDPTTGRPRKFAYPPNLYVVDGGAPQVAAAAEVLDELGITDVAV
IGLAKRLEEVWVPGEPDPVILPRNSEALFLLQRVRDEAHRFAITFHRSKRSRRMTASALDSVRGLGAARRTALVTHFGSV
AKLKEATVEEITEVPGIGVATAKAVLAALHQE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=684, Percent_Identity=35.0877192982456, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1788037, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_NOCFA (Q5YTP9)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119806.1
- ProteinModelPortal:   Q5YTP9
- GeneID:   3111632
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa35940
- NMPDR:   fig|247156.1.peg.3508
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   NFAR247156:NFA35940-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 74663; Mature: 74532

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPATYRPAPGTIPVEPGVYKFRDSYGRVIYVGKAKSLRSRLNSYFADVASLHPRTKQM
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHH
VTTAASVEWTVVSTEVEALQLEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEYPRLFVY
HHHHCCEEEEEEECEEEEEEEEHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCEEEEE
RGARKKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSTGVFKRHNQIGRPCLLGYIDKCS
ECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCC
APCVGRVSAEEHRAIVEDFCDFLAGRTDKMVRELERRMHAAAEDLDFETAARLRDDVQAL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RRALEKQAVVLGTGTDADVIAFATDELEVAVQIFHVRDGRVRGQRGWVVDKSGDAVDSGT
HHHHHCCEEEEECCCCCCEEEEECCHHEEEEEEEEECCCCEECCCCEEEECCCCCCCCCC
GDDETGALVEQFLTQFYGEQVAYADQTPDEQPATVVPREVLVPQLPAGHEQLQEWLSRLR
CCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHC
GSAVRLRVPQRGDKKALAETVERNAKEALAQHKLKRAGDLTSRSAALQDIQDALDLDSAP
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
LRIECVDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIKEAAGEGRSDDVGSIAEVTRRR
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHH
FYRLRKERDEAERDELDGTAAGAPLVDDDETPTSRPGIDPTTGRPRKFAYPPNLYVVDGG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCC
APQVAAAAEVLDELGITDVAVIGLAKRLEEVWVPGEPDPVILPRNSEALFLLQRVRDEAH
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHH
RFAITFHRSKRSRRMTASALDSVRGLGAARRTALVTHFGSVAKLKEATVEEITEVPGIGV
HEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ATAKAVLAALHQE
HHHHHHHHHHHCC
>Mature Secondary Structure 
ADPATYRPAPGTIPVEPGVYKFRDSYGRVIYVGKAKSLRSRLNSYFADVASLHPRTKQM
CCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHH
VTTAASVEWTVVSTEVEALQLEYNWIKEFDPRFNVRYRDDKSYPVLAVTLNEEYPRLFVY
HHHHCCEEEEEEECEEEEEEEEHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCEEEEE
RGARKKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSTGVFKRHNQIGRPCLLGYIDKCS
ECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCC
APCVGRVSAEEHRAIVEDFCDFLAGRTDKMVRELERRMHAAAEDLDFETAARLRDDVQAL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RRALEKQAVVLGTGTDADVIAFATDELEVAVQIFHVRDGRVRGQRGWVVDKSGDAVDSGT
HHHHHCCEEEEECCCCCCEEEEECCHHEEEEEEEEECCCCEECCCCEEEECCCCCCCCCC
GDDETGALVEQFLTQFYGEQVAYADQTPDEQPATVVPREVLVPQLPAGHEQLQEWLSRLR
CCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHC
GSAVRLRVPQRGDKKALAETVERNAKEALAQHKLKRAGDLTSRSAALQDIQDALDLDSAP
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
LRIECVDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIKEAAGEGRSDDVGSIAEVTRRR
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHH
FYRLRKERDEAERDELDGTAAGAPLVDDDETPTSRPGIDPTTGRPRKFAYPPNLYVVDGG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCC
APQVAAAAEVLDELGITDVAVIGLAKRLEEVWVPGEPDPVILPRNSEALFLLQRVRDEAH
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHH
RFAITFHRSKRSRRMTASALDSVRGLGAARRTALVTHFGSVAKLKEATVEEITEVPGIGV
HEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ATAKAVLAALHQE
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA