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The map label for this gene is tdh [H]

Identifier: 54025497

GI number: 54025497

Start: 3739089

End: 3740084

Strand: Reverse

Name: tdh [H]

Synonym: nfa35270

Alternate gene names: 54025497

Gene position: 3740084-3739089 (Counterclockwise)

Preceding gene: 54025498

Following gene: 54025496

Centisome position: 62.12

GC content: 78.31

Gene sequence:

>996_bases
GTGACGCGCGCGGCGGTGTGGACCGGTGCCGGGGTCGCGGTCCGCGACGTGCCGGTGCCGCGCCTGGCGCCGGGCCAATC
GCTGGTGCGGGTCCGCCTCGCCACGGTGTGCGGCAGCGACCTGCACACCGTCGCGGGTCGGCGTGCGGCACCGTGCCCGT
CGGTGCTCGGGCACGAGGCGGTCGGCGAGATCGTGGCCACCACGCCGCGGGCCGGGCACGGCGCGCCGGGACAGCGCATC
GTGTGGTCGGTGACGGCGGCGTGCGGGCGGTGCGCGCGGTGCCGCGCGGGCCGCACCGCCAAATGCCTGTCCGTGCGCAA
GGTCGGGCACGAGGCCTTCGACGGCGACTGGCCGCTGTCGGGCTCCTACGCCCGCCATCTCGTCCTGCCCGCGGGCGTGC
GCGCGGTGGCGGTGCCCGACGCGGTGCCCGACGCGGTGGCGGCCCCGGCCGCCTGCGCGACCGCCACGGTGATGGCCGCG
CTGGAGGCGGCCGGTGACCTGGCCGGGCGGCGGGTGCTCGTCTACGGGGCGGGCATGCTCGGGTTGACCGCCGCCGCGGC
CTGCGCGCACCGGGGCGCGCACGTCGCGGTACGCGACGTCGCCGCCGCCCGGGCGGCGTTGGCAGCGGGCTTCGGCGGCG
GGGCCGACGACGGCCTGCCGGTGGACGCCGCGTTCGACTTCTCCGGCTCGTCCGCCGCCATCGCCGATGCGCTCACCCGG
TTGGACATCGGCGGGGCGCTGGTGCTGGCCGGTTCGGTGGCGCCCGGTCCGCCGGTTTCGCTGGACGCGGAGCGGGTGGT
GCGCCGTTGGTTGCGCATCGCGGGCGTGCACAACTACGAGCCGCGGCACCTGACCGACGCCGTCGACTTCCTCGCCGCGA
CGGTGGGCACCTACCCCTGGCACGAACTGGTCGCCGAGCCGCTGCCGCTCGACGACATCGCCGCCGCCCTGACCGGTCCG
CCCGCCGGACGGACCCGCTGCGCCGTCGCACCCTGA

Upstream 100 bases:

>100_bases
GCACGCTCGAGTTCGGCGTCGCCGGCGCGATCGTGCTCGTCGTCTTCGCGCTCGTCTACTTCATCGAAAGGCTCTCCGGA
TGGATTCGCTCCCAGGTGGT

Downstream 100 bases:

>100_bases
CCCAAGCCGAGCCGGTTGCCGCTCAACGCCGCCACCGATGCCGCCGGTACTGGTCTATACCAATTGTTCACGTGCCGTTC
GCGGCGGGGACGCGCATAGG

Product: putative dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTRAAVWTGAGVAVRDVPVPRLAPGQSLVRVRLATVCGSDLHTVAGRRAAPCPSVLGHEAVGEIVATTPRAGHGAPGQRI
VWSVTAACGRCARCRAGRTAKCLSVRKVGHEAFDGDWPLSGSYARHLVLPAGVRAVAVPDAVPDAVAAPAACATATVMAA
LEAAGDLAGRRVLVYGAGMLGLTAAAACAHRGAHVAVRDVAAARAALAAGFGGGADDGLPVDAAFDFSGSSAAIADALTR
LDIGGALVLAGSVAPGPPVSLDAERVVRRWLRIAGVHNYEPRHLTDAVDFLAATVGTYPWHELVAEPLPLDDIAAALTGP
PAGRTRCAVAP

Sequences:

>Translated_331_residues
MTRAAVWTGAGVAVRDVPVPRLAPGQSLVRVRLATVCGSDLHTVAGRRAAPCPSVLGHEAVGEIVATTPRAGHGAPGQRI
VWSVTAACGRCARCRAGRTAKCLSVRKVGHEAFDGDWPLSGSYARHLVLPAGVRAVAVPDAVPDAVAAPAACATATVMAA
LEAAGDLAGRRVLVYGAGMLGLTAAAACAHRGAHVAVRDVAAARAALAAGFGGGADDGLPVDAAFDFSGSSAAIADALTR
LDIGGALVLAGSVAPGPPVSLDAERVVRRWLRIAGVHNYEPRHLTDAVDFLAATVGTYPWHELVAEPLPLDDIAAALTGP
PAGRTRCAVAP
>Mature_330_residues
TRAAVWTGAGVAVRDVPVPRLAPGQSLVRVRLATVCGSDLHTVAGRRAAPCPSVLGHEAVGEIVATTPRAGHGAPGQRIV
WSVTAACGRCARCRAGRTAKCLSVRKVGHEAFDGDWPLSGSYARHLVLPAGVRAVAVPDAVPDAVAAPAACATATVMAAL
EAAGDLAGRRVLVYGAGMLGLTAAAACAHRGAHVAVRDVAAARAALAAGFGGGADDGLPVDAAFDFSGSSAAIADALTRL
DIGGALVLAGSVAPGPPVSLDAERVVRRWLRIAGVHNYEPRHLTDAVDFLAATVGTYPWHELVAEPLPLDDIAAALTGPP
AGRTRCAVAP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790045, Length=291, Percent_Identity=31.6151202749141, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788073, Length=332, Percent_Identity=25.6024096385542, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=260, Percent_Identity=28.4615384615385, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790718, Length=314, Percent_Identity=25.4777070063694, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787863, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082125, Length=268, Percent_Identity=27.9850746268657, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081918, Length=177, Percent_Identity=27.683615819209, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786825, Length=219, Percent_Identity=29.2237442922374, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=334, Percent_Identity=23.0538922155689, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=266, Percent_Identity=27.8195488721804, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=175, Percent_Identity=30.2857142857143, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=169, Percent_Identity=27.2189349112426, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=226, Percent_Identity=27.4336283185841, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=251, Percent_Identity=27.4900398406374, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=240, Percent_Identity=28.3333333333333, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=302, Percent_Identity=25.1655629139073, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=215, Percent_Identity=30.2325581395349, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 33360; Mature: 33229

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAAVWTGAGVAVRDVPVPRLAPGQSLVRVRLATVCGSDLHTVAGRRAAPCPSVLGHEA
CCCCEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHH
VGEIVATTPRAGHGAPGQRIVWSVTAACGRCARCRAGRTAKCLSVRKVGHEAFDGDWPLS
HHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHCCCCCCCC
GSYARHLVLPAGVRAVAVPDAVPDAVAAPAACATATVMAALEAAGDLAGRRVLVYGAGML
CCCHHEEEECCCCEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
GLTAAAACAHRGAHVAVRDVAAARAALAAGFGGGADDGLPVDAAFDFSGSSAAIADALTR
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LDIGGALVLAGSVAPGPPVSLDAERVVRRWLRIAGVHNYEPRHLTDAVDFLAATVGTYPW
HCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCH
HELVAEPLPLDDIAAALTGPPAGRTRCAVAP
HHHHCCCCCHHHHHHHHCCCCCCCCEECCCC
>Mature Secondary Structure 
TRAAVWTGAGVAVRDVPVPRLAPGQSLVRVRLATVCGSDLHTVAGRRAAPCPSVLGHEA
CCCEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHH
VGEIVATTPRAGHGAPGQRIVWSVTAACGRCARCRAGRTAKCLSVRKVGHEAFDGDWPLS
HHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHCCCCCCCC
GSYARHLVLPAGVRAVAVPDAVPDAVAAPAACATATVMAALEAAGDLAGRRVLVYGAGML
CCCHHEEEECCCCEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
GLTAAAACAHRGAHVAVRDVAAARAALAAGFGGGADDGLPVDAAFDFSGSSAAIADALTR
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LDIGGALVLAGSVAPGPPVSLDAERVVRRWLRIAGVHNYEPRHLTDAVDFLAATVGTYPW
HCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCH
HELVAEPLPLDDIAAALTGPPAGRTRCAVAP
HHHHCCCCCHHHHHHHHCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA