Click here to switch to the map view.

The map label for this gene is fadA7 [H]

Identifier: 54025487

GI number: 54025487

Start: 3729859

End: 3731037

Strand: Reverse

Name: fadA7 [H]

Synonym: nfa35170

Alternate gene names: 54025487

Gene position: 3731037-3729859 (Counterclockwise)

Preceding gene: 54025488

Following gene: 54025485

Centisome position: 61.96

GC content: 74.3

Gene sequence:

>1179_bases
GTGAGCGGCGCGTTCGTCTACGACGGTGTCCGCACGCCGTTCGGGCGATACGGGGGCGGTCTGGCCGGCACCCGTCCCGA
CGATCTGGCCGCCCACGTGCTGCGCGCGCTGGCCGCACGGACCGGCCTCGACCCAGACACCGTCGACGAGGTGGTGCTCG
GCGCGGCCAACCAGGCCGGTGAGGACAACCGCAACGTCGCCAGGATGGCGGCGCTGCTGGCCGACTGGCCGACCGACGTG
CCCGCGACCACCGTCAACCGGCTGTGCGGGTCCGGCATGGACGCGATCATCCAGGCCTCCCGCACCATCGAGACCGGCGA
CGCGGAGCTGGTGGTGGCGGGCGGCGTGGAGTCGATGAGCCGGGCGCCGTGGGTACTGCCCAAGCCGGACAAGGCGTTTC
CGGCCGCGAACGCGACCGCTCACTCCACCACGCTGGGCTGGCGCCTGGTGAATCCGGCCATGCCCGCCCGGTGGACGGTG
TCGCTGGGGGAGAGCACCGAGATCCTCGCCGAGCGCTACGGTATCGGTCGCGCCGAACAGGACGAGTTCGCCGCCCGCAG
CCATCAGCTGGCCGCGCGCGCCTGGGACAGCGGCTTCTACGACGACCACGTGGTCGCGGTGCCCGGCAGCGAACTCGTGC
GCGACGAATCCCTGCGCCCCGCCACCACCGTCGAGACCCTCGCCCGGCTGAAGCCCGCCTTCCGCCCCGACGGCACGGTC
ACCGCGGGCAACGCCTCACCGCTCAACGACGGCGCCGCGGCGCTGCTGCTCGGCGACGAATCCGCCGCCGCCCGACTCGG
CCGCGAACCGCTGGCGCGGGTGGCCGGACGTGGGGCGGCCGGGGTCGACCCCGACGTGTTCGGCATCGGCCCGGTGCGCG
CGGCCGAGATCGCGTTGCGCCGCGCCGGCATCGACTGGGGGGATCTGGCCGCGGTGGAACTCAACGAGGCCTTCGCGGCG
CAGTCGCTGGCCTGCCTGGCCGACTGGCCCGAACTCGATCCCGCGATCGTCAACGTCAACGGCGGCGCCATCGCGCTCGG
CCACCCGCTCGGCGCCTCCGGTGGCCGCGTCGTCACCCAGCTGATCCATCAACTGCGCCGCGCCGGCGGCCGGTGGGGAC
TGGCGGCCCTGTGCATCGGCGTCGGCCAGGGCCTCGCGGTGGTCGTCGAAGCGGTGTGA

Upstream 100 bases:

>100_bases
CGGCGACCGGCTGGGACCTGCGCGTGGCCGACCACCCGGCGGTCTCGCCTGCCCCGACCGCCGAGGAACTGGCGACCCTG
CGCGCGCTGCGGGCGGCGTC

Downstream 100 bases:

>100_bases
CGCACGGCGGTCGACGGGTCAGATGGCTCGGGCGCGCCCGGACCAATGCGGTTCGCGCAGGGTACGTTTCAGGATCTTGC
CGCTGGCGTTCCTGGGCAGC

Product: putative ayl-CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSGAFVYDGVRTPFGRYGGGLAGTRPDDLAAHVLRALAARTGLDPDTVDEVVLGAANQAGEDNRNVARMAALLADWPTDV
PATTVNRLCGSGMDAIIQASRTIETGDAELVVAGGVESMSRAPWVLPKPDKAFPAANATAHSTTLGWRLVNPAMPARWTV
SLGESTEILAERYGIGRAEQDEFAARSHQLAARAWDSGFYDDHVVAVPGSELVRDESLRPATTVETLARLKPAFRPDGTV
TAGNASPLNDGAAALLLGDESAAARLGREPLARVAGRGAAGVDPDVFGIGPVRAAEIALRRAGIDWGDLAAVELNEAFAA
QSLACLADWPELDPAIVNVNGGAIALGHPLGASGGRVVTQLIHQLRRAGGRWGLAALCIGVGQGLAVVVEAV

Sequences:

>Translated_392_residues
MSGAFVYDGVRTPFGRYGGGLAGTRPDDLAAHVLRALAARTGLDPDTVDEVVLGAANQAGEDNRNVARMAALLADWPTDV
PATTVNRLCGSGMDAIIQASRTIETGDAELVVAGGVESMSRAPWVLPKPDKAFPAANATAHSTTLGWRLVNPAMPARWTV
SLGESTEILAERYGIGRAEQDEFAARSHQLAARAWDSGFYDDHVVAVPGSELVRDESLRPATTVETLARLKPAFRPDGTV
TAGNASPLNDGAAALLLGDESAAARLGREPLARVAGRGAAGVDPDVFGIGPVRAAEIALRRAGIDWGDLAAVELNEAFAA
QSLACLADWPELDPAIVNVNGGAIALGHPLGASGGRVVTQLIHQLRRAGGRWGLAALCIGVGQGLAVVVEAV
>Mature_391_residues
SGAFVYDGVRTPFGRYGGGLAGTRPDDLAAHVLRALAARTGLDPDTVDEVVLGAANQAGEDNRNVARMAALLADWPTDVP
ATTVNRLCGSGMDAIIQASRTIETGDAELVVAGGVESMSRAPWVLPKPDKAFPAANATAHSTTLGWRLVNPAMPARWTVS
LGESTEILAERYGIGRAEQDEFAARSHQLAARAWDSGFYDDHVVAVPGSELVRDESLRPATTVETLARLKPAFRPDGTVT
AGNASPLNDGAAALLLGDESAAARLGREPLARVAGRGAAGVDPDVFGIGPVRAAEIALRRAGIDWGDLAAVELNEAFAAQ
SLACLADWPELDPAIVNVNGGAIALGHPLGASGGRVVTQLIHQLRRAGGRWGLAALCIGVGQGLAVVVEAV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=39.5465994962217, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=39.6984924623116, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=37.5634517766497, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=35.427135678392, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI4504327, Length=418, Percent_Identity=36.8421052631579, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=29.2307692307692, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=51.6129032258064, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI48994986, Length=411, Percent_Identity=43.0656934306569, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI87082165, Length=397, Percent_Identity=42.3173803526448, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1788554, Length=397, Percent_Identity=41.8136020151133, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=34.4418052256532, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=38.4810126582278, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=33.5839598997494, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=35.8778625954198, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=33.1764705882353, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=29.1770573566085, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=36.5671641791045, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=32.7365728900256, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=42.25, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=37.6237623762376, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=36.6834170854271, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137578, Length=418, Percent_Identity=34.9282296650718, Blast_Score=201, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40543; Mature: 40412

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAFVYDGVRTPFGRYGGGLAGTRPDDLAAHVLRALAARTGLDPDTVDEVVLGAANQAG
CCCCEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
EDNRNVARMAALLADWPTDVPATTVNRLCGSGMDAIIQASRTIETGDAELVVAGGVESMS
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHCEEECCCCCEEEECCHHHHC
RAPWVLPKPDKAFPAANATAHSTTLGWRLVNPAMPARWTVSLGESTEILAERYGIGRAEQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCH
DEFAARSHQLAARAWDSGFYDDHVVAVPGSELVRDESLRPATTVETLARLKPAFRPDGTV
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCE
TAGNASPLNDGAAALLLGDESAAARLGREPLARVAGRGAAGVDPDVFGIGPVRAAEIALR
ECCCCCCCCCCCEEEEECCCHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
RAGIDWGDLAAVELNEAFAAQSLACLADWPELDPAIVNVNGGAIALGHPLGASGGRVVTQ
HCCCCHHCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCCHHHHHH
LIHQLRRAGGRWGLAALCIGVGQGLAVVVEAV
HHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
SGAFVYDGVRTPFGRYGGGLAGTRPDDLAAHVLRALAARTGLDPDTVDEVVLGAANQAG
CCCEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
EDNRNVARMAALLADWPTDVPATTVNRLCGSGMDAIIQASRTIETGDAELVVAGGVESMS
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHCEEECCCCCEEEECCHHHHC
RAPWVLPKPDKAFPAANATAHSTTLGWRLVNPAMPARWTVSLGESTEILAERYGIGRAEQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCH
DEFAARSHQLAARAWDSGFYDDHVVAVPGSELVRDESLRPATTVETLARLKPAFRPDGTV
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCE
TAGNASPLNDGAAALLLGDESAAARLGREPLARVAGRGAAGVDPDVFGIGPVRAAEIALR
ECCCCCCCCCCCEEEEECCCHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
RAGIDWGDLAAVELNEAFAAQSLACLADWPELDPAIVNVNGGAIALGHPLGASGGRVVTQ
HCCCCHHCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCCHHHHHH
LIHQLRRAGGRWGLAALCIGVGQGLAVVVEAV
HHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]