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The map label for this gene is pdhD

Identifier: 54020604

GI number: 54020604

Start: 737068

End: 738432

Strand: Reverse

Name: pdhD

Synonym: mhp587

Alternate gene names: 54020604

Gene position: 738432-737068 (Counterclockwise)

Preceding gene: 54020605

Following gene: 54020603

Centisome position: 82.71

GC content: 31.58

Gene sequence:

>1365_bases
ATGCAAAAATACGATGTAATTATTATTGGTGGTGGCCCTGGGGGTCATTCTCTAGCTGCTATTTTGGGTAAAAATGGTAA
AAAAGTTGCACTTTTTGAGCAAGAATTTCTCGGAGGAACCTGTGTAAATTGAGGATGTATTCCTACAAAAACAATTCTTA
AATCAGCAAAAATTAAATCTTATTTTGATAATGCAGAAAAATTTGGACTAAATTCAGTGGCGAAATTTAATTTTAAGCAA
ATTTTTCAAAGAGCAAAAAATAATTCACTAAAATTACAAGGCTCAATTTTAGAAACATTAAAAAATTCTGGTGTTGATTT
TTATAATAAAAAAGCAAAAGTTATATCAAATCATACAGTTTTAGCAGAAAATGAAGAATTTTTCTTTGAAAAATTAGTTA
TAGCAACAGGCTCTAAACCAAGAAAAATTAAAATTGAAGGTGCTGAAAGAGCAAATTTAATTACTTCTGATGATTTTTTT
AAAGGCAAAATTGAATTTGATGAACTAACAATCATTGGCGGTGGGGCAATTTCGCTTGAATTTGCAGTTTTTTATGCTAG
TTTTGGGGCAAAAATTACAATAATTGAAGGAAATGAGCGTGTTTTTGCCAATTTTGATAATTCAATTGCCGAGGCGGCAA
ATTTTGTTTTAGACAGAAACAAAGTGAAAATTTTTACTAAAACAAAAGTCAAAAAATATGAAAATGGGCAACTTTTACTT
GAAAAAGAAGGCAAAATTTTTGCTCATACAACCAAAAATATTCTTTTGGCAATCGGTCGTCAGCCCCAAAATGAGGCATT
CTCTGGTTTAAAAATTGATTTAGATAACCGTGGATTTCTAAAAATCAATAAATTTATGCAAACTTCAGTTCCAGATATTT
ATGCAATCGGTGACATTACCGGTCAAATGATGCTTTCATCAACGGCCTACAAACATGCTGATATTGTTGCAAAGCACATA
TTATTCGGTAGTTCTGATGAAGAATTTAGCGCAGAATTGATTCCTTGGGCAATTTATTCAATTCCGGAAATTGCTTCTGT
AGGGAAGACAGAAAAACAATTATTAAATTTGGATGTTGATTTTCAAAAAGCAAAAATTTTTGCAAAAAATTTGCCCCGTG
CCCACGCTAATGGCGAAATTGAGGCCGGTTTTATTGAGTTATTCTTCCATTCTAAAACTTTTGAAATTCTTGGATGTAAC
ATTTTCCTTGAAGAGGCTTCGCTTCTAGTCAATCAAGTTGCCCTTGCACTTTCGCAAAAATTAACAATTTTTGACTTGCA
AAAAATGGCTTATACCCATCCGAGCCTTAGCGAGGCATTTTATTATCTTTGTCGAAATATTACCTTTTCAAATCTTAAAA
AATAA

Upstream 100 bases:

>100_bases
AATTTTGTTCTTTTTATATAATAAAATTCAAAAATTAGTTATAATTAGTAGTAATACTAAAAATAAAAAGGTCAAAAAAA
ACAGAAAAAGCTGGAAAAAA

Downstream 100 bases:

>100_bases
AGAGGATTTAATAATTGTTTTTGCGCACTACAATTTCTTACTAGAGTAAAACTTAATCACAAATTTTAATAATTTGGAGT
ATATTAATTTAATGGTTTTT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVNWGCIPTKTILKSAKIKSYFDNAEKFGLNSVAKFNFKQ
IFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVISNHTVLAENEEFFFEKLVIATGSKPRKIKIEGAERANLITSDDFF
KGKIEFDELTIIGGGAISLEFAVFYASFGAKITIIEGNERVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLL
EKEGKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPDIYAIGDITGQMMLSSTAYKHADIVAKHI
LFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDFQKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCN
IFLEEASLLVNQVALALSQKLTIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK

Sequences:

>Translated_454_residues
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVN*GCIPTKTILKSAKIKSYFDNAEKFGLNSVAKFNFKQ
IFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVISNHTVLAENEEFFFEKLVIATGSKPRKIKIEGAERANLITSDDFF
KGKIEFDELTIIGGGAISLEFAVFYASFGAKITIIEGNERVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLL
EKEGKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPDIYAIGDITGQMMLSSTAYKHADIVAKHI
LFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDFQKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCN
IFLEEASLLVNQVALALSQKLTIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK
>Mature_454_residues
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVN*GCIPTKTILKSAKIKSYFDNAEKFGLNSVAKFNFKQ
IFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVISNHTVLAENEEFFFEKLVIATGSKPRKIKIEGAERANLITSDDFF
KGKIEFDELTIIGGGAISLEFAVFYASFGAKITIIEGNERVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLL
EKEGKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPDIYAIGDITGQMMLSSTAYKHADIVAKHI
LFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDFQKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCN
IFLEEASLLVNQVALALSQKLTIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=29.4117647058824, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI50301238, Length=438, Percent_Identity=25.5707762557078, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI291045266, Length=373, Percent_Identity=27.8820375335121, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI291045268, Length=354, Percent_Identity=28.8135593220339, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI22035672, Length=357, Percent_Identity=26.890756302521, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI148277065, Length=459, Percent_Identity=23.9651416122004, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=23.9651416122004, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=23.9651416122004, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=23.9651416122004, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI148277071, Length=459, Percent_Identity=23.9651416122004, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI226437568, Length=188, Percent_Identity=26.5957446808511, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21389617, Length=188, Percent_Identity=26.5957446808511, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI65787454, Length=188, Percent_Identity=26.5957446808511, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082354, Length=453, Percent_Identity=28.9183222958057, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=28.6324786324786, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=28.0087527352298, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789915, Length=427, Percent_Identity=25.9953161592506, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789065, Length=269, Percent_Identity=23.4200743494424, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=29.7180043383948, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983419, Length=336, Percent_Identity=26.1904761904762, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71983429, Length=336, Percent_Identity=26.1904761904762, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=24.4813278008299, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=390, Percent_Identity=24.8717948717949, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=30.1075268817204, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=30.6382978723404, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=379, Percent_Identity=25.3298153034301, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=27.9475982532751, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24640553, Length=377, Percent_Identity=27.3209549071618, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24640549, Length=377, Percent_Identity=27.3209549071618, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24640551, Length=377, Percent_Identity=27.3209549071618, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737741, Length=493, Percent_Identity=24.3407707910751, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50360; Mature: 50360

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVNGCIPTKTILKSAKIKSY
CCCEEEEEEECCCCCCHHHEEECCCCCEEEEEEHHHCCCEEECCCCCHHHHHHHHHHHHH
FDNAEKFGLNSVAKFNFKQIFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVISNHTVL
HCCHHHCCCCHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCEECCCEEEEECCEEE
AENEEFFFEKLVIATGSKPRKIKIEGAERANLITSDDFFKGKIEFDELTIIGGGAISLEF
ECCCHHHHHEEEEECCCCCCEEEEECCCCCCEEECCCCEECEEEEEEEEEEECCEEEEEE
AVFYASFGAKITIIEGNERVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLLE
EEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHEECCEEEEEEEEEEEEECCCCEEEE
KEGKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPDIYAIGDITG
ECCCEEEEECCEEEEEECCCCCCCCCCCCEEEECCCCEEEEEHHHHCCCCCEEEECCCHH
QMMLSSTAYKHADIVAKHILFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDF
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHCCCCHHHCCHHHHHCCCCCHHHEECCCCH
QKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCNIFLEEASLLVNQVALALSQKL
HHHHHHHHCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEEEEHHHHHHHHHHHHHHHCCC
TIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK
EEEEHHHHHCCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVNGCIPTKTILKSAKIKSY
CCCEEEEEEECCCCCCHHHEEECCCCCEEEEEEHHHCCCEEECCCCCHHHHHHHHHHHHH
FDNAEKFGLNSVAKFNFKQIFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVISNHTVL
HCCHHHCCCCHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCEECCCEEEEECCEEE
AENEEFFFEKLVIATGSKPRKIKIEGAERANLITSDDFFKGKIEFDELTIIGGGAISLEF
ECCCHHHHHEEEEECCCCCCEEEEECCCCCCEEECCCCEECEEEEEEEEEEECCEEEEEE
AVFYASFGAKITIIEGNERVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLLE
EEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHEECCEEEEEEEEEEEEECCCCEEEE
KEGKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPDIYAIGDITG
ECCCEEEEECCEEEEEECCCCCCCCCCCCEEEECCCCEEEEEHHHHCCCCCEEEECCCHH
QMMLSSTAYKHADIVAKHILFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDF
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHCCCCHHHCCHHHHHCCCCCHHHEECCCCH
QKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCNIFLEEASLLVNQVALALSQKL
HHHHHHHHCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEEEEHHHHHHHHHHHHHHHCCC
TIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK
EEEEHHHHHCCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]